[1]夏 军,张显利.多层螺旋CT增强扫描联合癌胚抗原、糖类抗原24-2、糖类抗原72-4检测对大肠癌术前分期诊断的价值研究[J].陕西医学杂志,2021,50(12):1517-1520.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.012]
　XIA Jun,ZHANG Xianli.Value of MSCT enhanced scanning combined with CEA,CA242 and CA724 in preoperative staging diagnosis of colorectal cancer[J].,2021,50(12):1517-1520.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.012]
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多层螺旋CT增强扫描联合癌胚抗原、糖类抗原24-2、糖类抗原72-4检测对大肠癌术前分期诊断的价值研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1517-1520
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Value of MSCT enhanced scanning combined with CEA,CA242 and CA724 in preoperative staging diagnosis of colorectal cancer
作者:
夏 军1; 张显利2
(1.咸阳市中心医院CT诊断室,陕西 咸阳 712000; 2.咸阳市中心医院放射诊断科,陕西 咸阳 712000)
Author(s):
XIA Jun; ZHANG Xianli
(CT Diagnosis Room of Xianyang Central Hospital,Xianyang 712000,China)
关键词:
大肠癌;  多层螺旋CT;  癌胚抗原;  糖类抗原24-2;  糖类抗原72-4;  术前分期诊断
Keywords:
Colorectal cancer;  Multi-slice spiral CT;  Carcinoembryonic antigen;  Carbohydrate antigen 24-2;  Carbohydrate antigen 72-4;  Preoperative staging diagnosis
分类号:
R 735.34
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.012
文献标志码:
A
摘要:
目的:探讨多层螺旋CT(MSCT)增强扫描联合癌胚抗原(CEA)、糖类抗原24-2(CA242)、糖类抗原72-4(CA724)对大肠癌术前分期诊断的价值。方法:选取大肠癌患者82例为大肠癌组,其中Ⅰ期39例,Ⅱ期24例,Ⅲ-Ⅳ期19例。选取同期进行体检的健康人群82例为健康组。对大肠癌患者进行MSCT检查。对所有研究对象进行血清CEA、CA242、CA724表达水平检测。对患者MSCT图像进行分析,统计分期诊断结果。比较两组CEA、CA242、CA724表达水平。比较不同分期大肠癌患者CEA、CA242、CA724表达水平。比较MSCT、CEA、CA242、CA724 单项及联合对大肠癌患者术前分期诊断的价值。结果:MSCT检出大肠癌患者41例,其中Ⅰ期17例,Ⅱ期12例,Ⅲ-Ⅳ期12例。大肠癌组CEA、CA242、CA724表达水平明显高于健康组(均P<0.05)。不同分期大肠癌患者CEA、CA242、CA724表达水平比较差异有统计学意义,且随着临床分期进展呈逐渐上升趋势(均P<0.05)。MSCT联合CEA、CA242、CA724对大肠癌患者术前分期诊断的准确率分别为97.43%(Ⅰ期)、100.00%(Ⅱ期)、100.00%(Ⅲ-Ⅳ期),总检出准确率为98.78%,均高于MSCT、CEA、CA242、CA724单项检查(均P<0.05)。结论:MSCT增强扫描联合CEA、CA242、CA724检测可提高大肠癌患者术前分期诊断的准确性,为临床治疗方案选择提供重要参考信息。
Abstract:
Objective:To investigate the value of multi-slice spiral CT(MSCT)enhanced scanning combined with carcinoembryonic antigen(CEA),carbohydrate antigen 24-2(CA242)and CA724 in the preoperative staging diagnosis of colorectal cancer.Methods:82 patients with colorectal cancer were selected as colorectal cancer group,including 39 cases in stage Ⅰ,24 cases in stage Ⅱ and 19 cases in stage Ⅲ-Ⅳ.82 healthy people who underwent physical examination in the same period were selected as the healthy group.MSCT was performed in patients with colorectal cancer.The expression levels of serum CEA,CA242 and CA724 were detected in all subjects.The MSCT images of patients were analyzed and the staging diagnosis results were counted.The expression levels of CEA,CA242 and CA724 were compared between the two groups.The expression levels of CEA,CA242 and CA724 in patients with different stages of colorectal cancer were compared.The values of single and combined detection of MSCT,CEA,CA242 and CA724 in preoperative staging diagnosis of patients with colorectal cancer were compared.Results:41 patients with colorectal cancer were detected by MSCT,including 17 cases in stage Ⅰ,12 cases in stage Ⅱ and 12 cases in stage Ⅲ-Ⅳ.The expression levels of CEA,CA242 and CA724 in colorectal cancer group were significantly higher than those in healthy group(all P<0.05).The expression levels of CEA,CA242 and CA724 in patients with different stages of colorectal cancer were statistically significant,and showed a gradual upward trend with the progress of clinical stage(all P<0.05).The accuracy of MSCT combined with CEA,CA242 and CA724 in preoperative staging diagnosis were 97.43%(stage Ⅰ),100.00%(stage Ⅱ)and 100.00%(stage Ⅲ-Ⅳ)respectively,and the total detection accuracy was 98.78%,which was higher than that of single detection of MSCT,CEA,CA242 and CA724(all P<0.05).Conclusion:MSCT enhanced scanning combined with CEA,CA242 and CA724 can improve the accuracy of preoperative staging diagnosis of patients with colorectal cancer and provide important reference information for the selection of clinical treatment.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-266)
更新日期/Last Update: 2021-12-07