[1]刘 琪,夏 杰,冯以斌,等.细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群表达水平与预后相关性分析[J].陕西医学杂志,2021,50(12):1510-1512,1516.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.010]
　LIU Qi,XIA Jie,FENG Yibin,et al.Correlation between expression levels of peripheral blood T lymphocyte subsets and prognosis in patients with bacterial liver abscess and type 2 diabetes[J].,2021,50(12):1510-1512,1516.[doi:DOI:10.3969/j.issn.1000-7377.2021.12.010]
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细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群表达水平与预后相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年12期
页码:
1510-1512,1516
栏目:
临床研究
出版日期:
2021-12-05

文章信息/Info

Title:
Correlation between expression levels of peripheral blood T lymphocyte subsets and prognosis in patients with bacterial liver abscess and type 2 diabetes
作者:
刘 琪1; 夏 杰2; 冯以斌2; 周启锋2; 吴 鹏2
(1.杨凌示范区医院肝胆普外科,陕西 杨凌 712100; 2.安康市中心医院普通外科,陕西 安康 725000)
Author(s):
LIU Qi; XIA Jie; FENG Yibin; ZHOU Qifeng; WU Peng
(Department of Hepatobiliary General Surgery,Yangling Demonstration Zone Hospital,Yangling 712100,China)
关键词:
细菌性肝脓肿;  2型糖尿病;  T淋巴细胞亚群;  预后;  相关性
Keywords:
Bacterial liver abscess;  Type 2 diabetes;  T lymphocyte subsets;  Prognosis;  Correlation
分类号:
R 575.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.12.010
文献标志码:
A
摘要:
目的:探讨细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群表达水平与预后的相关性。方法:选取细菌性肝脓肿患者66例作为研究对象,根据是否合并2型糖尿病分为合并组(26例)和非合并组(40例)。比较两组患者白细胞计数、空腹血糖、餐后2 h血糖、T淋巴细胞亚群水平以及预后情况。分析T淋巴细胞亚群表达水平与患者预后的相关性。结果:合并组患者白细胞计数、空腹血糖、餐后2 h血糖高于非合并组(均P<0.05)。合并组患者CD3+与CD4+ T淋巴细胞水平低于非合并组(均P<0.05)。治疗后3个月,合并组预后良好者占比为76.9%,低于对照组的97.5%(P<0.05)。Spearman相关性分析显示,患者预后与CD3+、CD4+ T淋巴细胞水平存在相关性(rs=0.644、0.582,均P<0.05)。二分类Logistic回归分析显示,CD3+、CD4+ T淋巴细胞水平为影响患者预后的重要因素(均P<0.05)。结论:细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群水平下降,预后变差; CD3+、CD4+ T淋巴细胞水平为影响患者预后的重要因素。
Abstract:
Objective:To investigate the correlation between expression levels of peripheral blood T lymphocyte subsets and prognosis in patients with bacterial liver abscess and type 2 diabetes.Methods:A total of 66 patients with bacterial liver abscess were selected as the research objects,and they were divided into combined group(26 cases)and non-combined group(40 cases)according to whether they had type 2 diabetes.The white blood cell count,fasting blood glucose,postprandial 2-hour blood glucose,T lymphocyte subsets levels,and prognosis were compared between the two groups.The correlation between the expression levels of T lymphocyte subsets and the prognosis of patients was analyzed.Results:The white blood cell count,fasting blood glucose,and postprandial 2-hour blood glucose in the combined group were higher than those in the non-combined group(all P<0.05).The levels of CD3+ and CD4+ T lymphocytes in the combined group was lower than that in the non-combined group(all P<0.05).Three months after treatment,the proportion of patients with good prognosis in the combined group was 76.9%,which was lower than 97.5% in the control group(P<0.05).Spearman correlation analysis showed that the prognosis of patients was correlated with the levels of CD3+ and CD4+ T lymphocytes(rs=0.644,0.582,both P<0.05).The binary Logistic regression analysis showed that the levels of CD3+ and CD4+ T lymphocytes were important factors affecting the prognosis of patients(all P<0.05).Conclusion:The levels of T lymphocyte subsets in peripheral blood of patients with bacterial liver abscess and type 2 diabetes decreases,and the prognosis becomes worse.The levels of CD3+ and CD4+ T lymphocytes are important factors affecting the prognosis of patients.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(8176120058); 陕西省安康市科学技术研究发展指导计划项目(AK2020-SFZC-14)
更新日期/Last Update: 2021-12-07