[1]屈 慧,皇 海,张 蕊.血清细胞角蛋白18、骨桥蛋白水平与原发性喉癌患者临床分期相关性研究[J].陕西医学杂志,2021,50(11):1452-1456.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.033]
　QU Hui,HUANG Hai,ZHANG Rui.Correlation between serum cytokeratin 18,osteopontin levels and clinical stage of patients with primary laryngeal carcinoma[J].,2021,50(11):1452-1456.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.033]
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血清细胞角蛋白18、骨桥蛋白水平与原发性喉癌患者临床分期相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年11期
页码:
1452-1456
栏目:
临床病理
出版日期:
2021-11-05

文章信息/Info

Title:
Correlation between serum cytokeratin 18,osteopontin levels and clinical stage of patients with primary laryngeal carcinoma
作者:
屈 慧; 皇 海; 张 蕊
(空军军医大学西京医院,陕西 西安710032)
Author(s):
QU Hui; HUANG Hai; ZHANG Rui
(Xijing Hospital of Air Force Medical University,Xi'an 710032,China)
关键词:
原发性喉癌;  细胞角蛋白18;  骨桥蛋白;  临床分期;  相关性;  肿瘤标志物
Keywords:
Primary laryngeal carcinoma;  Cytokeratin 18;  Osteopontin;  Clinical stage;  Correlation;  Tumor marker
分类号:
R 739.65
DOI:
DOI:10.3969/j.issn.1000-7377.2021.11.033
文献标志码:
A
摘要:
目的:探讨血清细胞角蛋白18(CK18)、骨桥蛋白(OPN)水平与原发性喉癌患者临床分期的关系。方法:选择93例原发性喉癌患者作为研究对象,入院时检测患者的CK18、细胞角蛋白19(CK19)、OPN、肿瘤标志物水平[糖类抗原50(CA50)、糖类抗原199(CAl99)、癌胚抗原(CEA)、糖脂类抗原72-4(CA72-4)],均接受纤维喉镜和病理活检,并根据检查结果分为晚期[国际抗癌联盟制定的肿瘤(TNM)分期Ⅲ、Ⅳ期]和早中期(TNM分期Ⅰ、Ⅱ期),比较不同临床分期患者的CK18、CK19、OPN、肿瘤标志物水平,重点分析入院时血清CK18、OPN水平与原发性喉癌患者临床分期的关系。结果:晚期组CK18、CK19、OPN、CA50、CA199、CEA、CA72-4高于早中期组(均P<0.05); Logistic回归分析显示,入院时血清CK18、CK19、OPN、CA50、CA199、CEA、CA72-4水平与原发性喉癌患者临床分期有关,CK18、CK19、OPN、CA50、CA199、CEA、CA72-4高表达可能是原发性喉癌患者进展至晚期的风险因子(OR>1,P<0.05); ROC曲线图显示,入院时血清CK18、OPN单独及联合评估原发性喉癌患者预后不良的AUC分别为0.886、0.832、0.899,均有一定评估价值; 经Spearman相关性分析检验,原发性喉癌患者血清CK18、OPN呈正相关(r=0.353,P<0.001)。结论:血清CK18、OPN水平与原发性喉癌患者临床分期相关,可用于原发性喉癌患者临床分期的评估。
Abstract:
Objective:To analyze the relationship between serum cytokeratin 18(CK18)and osteopontin(OPN)levels and clinical stage of patients with primary laryngeal carcinoma.Methods:93 patients with primary laryngeal cancer were selected as the research subjects.The levels of CK18,cytokeratin 19(CK19),OPN and tumor markers [carbohydrate antigen 50(CA50),carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA)and glycolipid antigen 72-4(CA72-4)] of patients were detected at admission.All patients underwent fibrolaryngoscope and pathological biopsy,according to the examination results,they were divided into advanced stage(TNM stage Ⅲ and Ⅳ)and early and middle stage(TNM stage Ⅰ and Ⅱ).The levels of CK18,CK19,OPN and tumor markers in patients with different clinical stages were compared,and the relationship between serum CK18,OPN levels at admission and clinical stage of patients with primary laryngeal carcinoma was mainly analyzed.Results:The levels of CK18,CK19,OPN,CA50,CA199,CEA,CA72-4 in the advanced stage group were higher than those in the early and middle stage group(all P<0.05).Logistic regression analysis showed that the serum CK18,CK19,OPN,CA50,CA199,CEA and CA72-4 levels were related to the clinical stage of patients with primary laryngeal carcinoma,and the high expression of CK18,CK19,OPN,CA50,CA199,CEA and CA72-4 might be risk factors for the progression to advanced stage of patients with primary laryngeal carcinoma(OR>1,P<0.05).ROC curve showed that the AUC of serum CK18 and OPN alone and in combination in evaluating the poor prognosis of patients with primary laryngeal carcinoma were 0.886,0.832 and 0.899 respectively,which had a certain predicted value.Spearman correlation analysis showed that serum CK18 and OPN were positively correlated in patients with primary laryngeal cancer(r=0.353,P<0.001).Conclusion:Serum CK18 and OPN levels are correlated with clinical stage of patients with primary laryngeal carcinoma,which can be used to evaluate the clinical stage of patients with primary laryngeal carcinoma.

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备注/Memo

备注/Memo:
基金项目:空军军医大学西京医院学科助推项目(XJZT18ML50)
更新日期/Last Update: 2021-11-05