[1]马淑萍,蒙玉娜,党春艳,等.锰超氧化物歧化酶和过氧化物酶6在弥漫性大B细胞淋巴瘤中的表达及临床意义[J].陕西医学杂志,2021,50(9):1154-1157.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.028]
　MA Shuping,MENG Yu'na,DANG Chunyan,et al.Expression and clinical significance of MnSOD and PRDX6 in diffuse large B-cell lymphoma[J].,2021,50(9):1154-1157.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.028]
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锰超氧化物歧化酶和过氧化物酶6在弥漫性大B细胞淋巴瘤中的表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1154-1157
栏目:
临床病理
出版日期:
2021-09-05

文章信息/Info

Title:
Expression and clinical significance of MnSOD and PRDX6 in diffuse large B-cell lymphoma
作者:
马淑萍1; 蒙玉娜2; 党春艳1; 李红玲1
(1.甘肃省人民医院肿瘤内科,甘肃 兰州 730000; 2.宁夏医科大学,宁夏 银川 750000)
Author(s):
MA Shuping; MENG Yu'na; DANG Chunyan; LI Hongling
(Department of Oncolgy,Gansu Provincial Hospital,Lanzhou 730000,China)
关键词:
弥漫性大B细胞淋巴瘤;  锰超氧化物歧化酶;  过氧化物酶6;  免疫组化;  国际预后指数;  氧化应激
Keywords:
Diffuse large B-cell lymphoma;  MnSOD;  PRDX6;  Immunohistochemistry;  International Prognostic Index;  Oxidative stress
分类号:
R 733.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.028
文献标志码:
A
摘要:
目的:探讨锰超氧化物歧化酶(MnSOD)和过氧化物酶6(PRDX6)在弥漫大 B 细胞淋巴瘤(DLBCL)中的表达及其临床意义。方法:应用免疫组化SP法检测60例DLBCL患者(DLBCL组)及20例淋巴结反应性增生(RHL)患者(RHL组)组织中MnSOD和PRDX6的表达,并分析两者表达与患者临床病理特征之间的关系。结果:DLBCL组MnSOD和PRDX6阳性表达率高于RHL组(均P<0.05)。两者的表达与临床分期、B症状、国际预后指数(IPI)评分有关(均P<0.05)。Spearman相关性分析表明,两者在DLBCL组织中的表达呈正相关(r=0.133,P=0.019)。结论:MnSOD和PRDX6在DLBCL组织中均呈高表达,与临床分期、B症状、IPI评分相关,可能参与了DLBCL 的发生与发展过程。
Abstract:
Objective:To investigate the expression of MnSOD and PRDX6 in diffuse large B-cell lymphoma(DLBCL)and its clinical significance.Methods:Immunohistochemical SP method was used to detect the expression of MnSOD and PRDX6 in the tissues of 60 DLBCL patients(DLBCL group)and 20 RHL patients(RHL group).The relationship between their expression and clinicopathological characteristics was analyzed.Results:The positive expression rate of MnSOD and PRDX6 in DLBCL group was higher than that in RHL group(both P<0.05).The expression of both was related to clinical stage,B symptoms,and IPI score(both P<0.05).Spearman correlation analysis showed that the expression of the two in DLBCL tissues was positively correlated(r=0.133,P=0.019).Conclusion:Both MnSOD and PRDX6 are highly expressed in DLBCL tissues,which are related to clinical stage,B symptoms,and IPI score,and may be involved in the occurrence and development of DLBCL.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81760537,81560498)
更新日期/Last Update: 2021-09-06