[1]马显平,张海斌.叉头框转录因子M1和增殖细胞核抗原在食管癌组织中的表达及与放化疗预后相关性分析[J].陕西医学杂志,2021,50(9):1150-1153.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.027]
　MA Xianping,ZHANG Haibin.Expression of FOXM1 and PCNA in esophageal carcinoma and their correlation with prognosis of radiotherapy and chemotherapy[J].,2021,50(9):1150-1153.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.027]
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叉头框转录因子M1和增殖细胞核抗原在食管癌组织中的表达及与放化疗预后相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1150-1153
栏目:
临床病理
出版日期:
2021-09-05

文章信息/Info

Title:
Expression of FOXM1 and PCNA in esophageal carcinoma and their correlation with prognosis of radiotherapy and chemotherapy
作者:
马显平1; 张海斌2
(1.陕西省核工业二一五医院肿瘤放疗科,陕西 咸阳 712000; 2.铜川市人民医院普外胸外科,陕西 铜川 727000)
Author(s):
MA Xianping; ZHANG Haibin
(Department of Oncology Radiotherapy,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,China)
关键词:
食管癌;  叉头框转录因子M1;  增殖细胞核抗原;  放化疗;  预后;  相关性
Keywords:
Esophageal cancer;  FOXM1;  PCNA;  Radiotherapy and chemotherapy;  Prognosis;  Correlation
分类号:
R 735.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.027
文献标志码:
A
摘要:
目的:探讨叉头框转录因子M1(FOXM1)和增殖细胞核抗原(PCNA)在食管癌组织中的表达,分析其与放化疗预后的相关性。方法:选取行同期放化疗的食管癌患者86例作为研究对象。取所有患者的癌组织标本与癌旁组织标本,检测FOXM1和PCNA表达水平。所有患者都给予放化疗治疗,随访预后并进行相关性分析。结果:食管癌组织FOXM1和PCNA表达水平高于癌旁组织(均P<0.05)。不同组织学分化、临床分期、淋巴结转移、病灶直径食管癌患者的FOXM1和PCNA表达水平对比差异有统计学意义(均P<0.05)。所有患者经放化疗治疗后,随访到2020年12月1日,86例患者中死亡21例,死亡率为24.4%,Pearson分析显示食管癌患者放化疗预后与FOXM1、PCNA表达水平具有相关性(P<0.05)。Logistic回归模型显示FOXM1、PCNA表达水平都为影响食管癌患者放化疗预后死亡的重要因素(r=0.542、0.443,均P<0.05)。结论:FOXM1和PCNA在食管癌组织中呈现高表达,与患者病理特征存在相关性,也是影响患者放化疗预后的重要影响因素。
Abstract:
Objective:To investigate the expression of forkhead box protein M1(FOXM1)and proliferating cell nuclear antigen(PCNA)in esophageal carcinoma and analyze their correlation with the prognosis of radiotherapy and chemotherapy.Methods:86 cases of esophageal cancer patients who underwent concurrent radiotherapy and chemotherapy were selected as the research objects.The lesion tissue specimens and paracancerous tissue specimens of all patients were collected to detect the expression levels of FOXM1 and PCNA.All patients were given radiotherapy and chemotherapy,and the prognosis was followed up and the correlation was analyzed.Results:The expression levels of FOXM1 and PCNA in esophageal cancer lesion tissue were higher than those in adjacent tissues(all P<0.05).In patients with esophageal cancer,the expression levels of FOXM1 and PCNA in different histological differentiation,clinical stage,lymph node metastasis,and lesion diameter were significantly different(all P<0.05).After all patients were treated with radiotherapy and chemotherapy,they were followed up until December 1,2020,there were 21 deaths among 86 patients,with the mortality rate of 24.4%.Pearson analysis showed that the prognosis of esophageal cancer patients after radiotherapy and chemotherapy was correlated with the expression levels of FOXM1 and PCNA(all P<0.05).Logistic regression model showed that FOXM1 and PCNA expression levels were the important factors influencing the prognosis of patients with esophageal cancer(r=0.542,0.443,all P<0.05).Conclusion:FOXM1 and PCNA are highly expressed in esophageal cancer tissues,which are correlated with the pathological characteristics of patients,and are also important factors affecting the prognosis of patients with radiotherapy and chemotherapy.

参考文献/References:

[1] 于耀洋,赵 佳,李向楠.抑制转移相关基因1的表达对食管癌Eca109细胞增殖和凋亡的影响[J].中华肿瘤杂志,2020,42(3):197-202.
[2] 刘小玉.窄带成像放大内镜结合卢戈氏染色对食管癌癌前病变及早期癌诊断的应用价值[J].陕西医学杂志,2020,49(9):131-133.
[3] 木亚林,岳 恺,李 明.miR-381-3p靶向特异性蛋白1抑制mTOR/p70s6k信号通路调控食管癌细胞的增殖和凋亡[J].成都医学院学报,2020,15(1):33-39,132.
[4] Biechele J,Fox M.A patient with metastatic lung cancer and dysphagia[J].Gastroenterology,2020,158(3):485-487.
[5] 王 军,魏 洁,江海峰,等.Ⅲ期老年胸段食管癌术后放疗与同步放化疗临床疗效对比研究[J].陕西医学杂志,2018,47(12):1568-1571,1575.
[6] 杨 潮,戴 京,张欣宇,等.人转录因子FoxM1B的生物信息学分析[J].生物技术通讯,2019,30(3):371-377.
[7] 孟繁超,冯 鹭,邵广瑞.人乳腺癌细胞系MCF-7中FOXM1调控SYK转录[J].山东大学学报:医学版,2017,55(3):19-24.
[8] 童 薇,张 敬,朱艳丽,等.食管鳞癌中STC2、MMP-9及PCNA表达情况[J].实用癌症杂志,2020,35(3):388-390,402.
[9] 魏起友,韩巴特尔,赵德惠,等.新辅助放化疗联合手术治疗晚期食管癌的临床疗效[J].中国医药科学,2015,5(7):9-11,15.
[10] 巫 姜,石文龙,牛 进,等.miR-34c-3p与增殖细胞核抗原在三阴性乳腺癌组织和血清中的表达及意义[J].现代肿瘤医学,2020,28(20):75-81.
[11] 邢涛涛,韩郭杰,王晓玉,等.不同麻醉深度对微创Mc Keown食管癌根治术患者术后认知功能的影响[J].肿瘤研究与临床,2020,32(4):289-294.
[12] 张 森,何威华,华 松,等.扶正消瘤汤对食管癌患者放疗前后临床症状、细胞免疫功能及外周血细胞凋亡的影响[J].陕西中医,2018,39(11):1511-1514.
[13] 曹 彬.全胸腔镜下食管癌切除术与常规手术的对比研究[J].中华生物医学工程杂志,2020,26(1):67-70.
[14] 王思毓,刘 珊,蒋永新.FOXM1在结直肠癌中的作用及其机制[J].中国肿瘤生物治疗杂志,2020,27(5):109-114.
[15] 李佩琴,杨少芬,翁雅倩,等.食管鳞状细胞癌中FOXM1基因的表达及临床意义[J].临床与实验病理学杂志,2018,34(6):591-594,600.
[16] 杨兴肖,邹乃祎,李巧芳,等.RNF2和PCNA在食管鳞状细胞癌中的表达及临床意义[J].癌变?畸变?突变,2018,30(4):254-257.
[17] 杨 艳,韦淑贞,杜云翔,等.p53、Ki-67、PCNA的表达与食管鳞癌放疗近期疗效及预后的关系[J].东南大学学报:医学版,2017,36(2):155-161.
[18] 董 倩,师颖瑞,叶 旭,等.Cdc25C在食管鳞状细胞癌中的表达及与预后的关系[J].中国现代医学杂志,2020,30(9):43-48.
[19] 马 超.沉默FoxM1基因对食管鳞癌ECA-109细胞的上皮间质转化的影响及相关研究[D].衡阳:南华大学,2017.
[20] 刘 涛,杨宣涛.FOXM1和PCNA在食管癌组织中的表达情况及临床价值分析[J].胃肠病学和肝病学杂志,2019,28(4):425-428.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2017SF-068)
更新日期/Last Update: 2021-09-06