[1]李荣芳,金 龙,赵立丹.外周血T细胞免疫球蛋白黏蛋白-3和血清乳酸脱氢酶联合检测在骨髓增生异常综合征诊断中的应用价值[J].陕西医学杂志,2021,50(9):1143-1146.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.025]
　LI Rongfang,JIN Long,ZHAO Lidan.Application value of combined detection of peripheral blood TIM-3 and serum LDH in diagnosis of MDS[J].,2021,50(9):1143-1146.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.025]
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外周血T细胞免疫球蛋白黏蛋白-3和血清乳酸脱氢酶联合检测在骨髓增生异常综合征诊断中的应用价值

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1143-1146
栏目:
临床检验
出版日期:
2021-09-05

文章信息/Info

Title:
Application value of combined detection of peripheral blood TIM-3 and serum LDH in diagnosis of MDS
作者:
李荣芳; 金 龙; 赵立丹
(西安市第九医院老年病科,陕西 西安 710054)
Author(s):
LI Rongfang; JIN Long; ZHAO Lidan
(Department of Geriatrics,Ninth Hospital of Xi'an,Xi'an 710054,China)
关键词:
骨髓增生异常综合征;  T细胞免疫球蛋白黏蛋白-3;  乳酸脱氢酶;  外周血单核细胞;  联合检测;  诊断价值
Keywords:
Myelodysplastic syndrome;  TIM-3;  LDH;  PBMC;  Combined detection;  Diagnostic value
分类号:
R 551.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.025
文献标志码:
A
摘要:
目的:探究外周血T细胞免疫球蛋白黏蛋白-3(TIM-3)和血清乳酸脱氢酶(LDH)联合检测在骨髓增生异常综合征(MDS)诊断中的应用价值。方法:选取98例MDS患者作为MDS组,选取同期36名健康体检者作为对照组。检测两组外周血单核细胞(PBMC)表面TIM-3和血清LDH表达水平并进行比较。采用受试者工作特征(ROC)曲线分析TIM-3、LDH单项及联合检测诊断MDS的价值。结果:MDS组TIM-3和LDH表达水平高于对照组(均P<0.05)。不同预后分级MDS患者TIM-3和LDH表达水平比较,差异无统计学意义(均P>0.05)。TIM-3、LDH联合检测诊断MDS的敏感性与特异性分别为88.70%和68.12%,高于TIM-3、LDH单项检测。结论:MDS患者外周血TIM-3和LDH表达水平异常升高,二者联合检测有助于提高对MDS的诊断准确率。
Abstract:
Objective:To explore the application value of combined detection of peripheral blood T cell immunoglobulin and mucin domain 3(TIM-3)and serum lactate dehydrogenase(LDH)in the diagnosis of myelodysplastic syndrome(MDS).Methods:98 MDS patients were selected as the MDS group,and 36 healthy subjects in the same period were selected as the control group.The two groups of peripheral blood mononuclear cells(PBMC)surface TIM-3 and serum LDH expression levels were detected and compared.The receiver operating characteristic(ROC)curve was used to analyze the value of TIM-3,LDH single and combined detection in the diagnosis of MDS.Results:The expression levels of TIM-3 and LDH in the MDS group were higher than those in the control group(all P<0.05).There was no statistically significant difference in the expression levels of TIM-3 and LDH in MDS patients with different prognostic grades(all P>0.05).The sensitivity and specificity of combined detection of TIM-3 and LDH in the diagnosis of MDS were 88.70% and 68.12%,respectively,which were higher than that of TIM-3 and LDH single detection.Conclusion:The expression levels of TIM-3 and LDH in the peripheral blood of MDS patients are abnormally increased.The combined detection of the two can help improve the accuracy of the diagnosis of MDS.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划项目(2020JQ-960)
更新日期/Last Update: 2021-09-06