[1]申文文,延欢欢.不同类型慢性心力衰竭患者血清肌钙蛋白T和N末端B型钠尿肽原水平变化及临床意义[J].陕西医学杂志,2021,50(9):1109-1113.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.017]
　SHEN Wenwen,YAN Huanhuan.Changes and clinical significance of serum TnT and NT-proBNP levelsin patients with different types of CHF[J].,2021,50(9):1109-1113.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.017]
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不同类型慢性心力衰竭患者血清肌钙蛋白T和N末端B型钠尿肽原水平变化及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1109-1113
栏目:
临床研究
出版日期:
2021-09-05

文章信息/Info

Title:
Changes and clinical significance of serum TnT and NT-proBNP levelsin patients with different types of CHF
作者:
申文文1; 延欢欢2
(1.铜川矿务局中心医院检验科,陕西 铜川 727000; 2.铜川市人民医院检验科,陕西 铜川 727000)
Author(s):
SHEN Wenwen; YAN Huanhuan
(Department of Laboratory Medicine,Central Hospital of Tongchuan Mining Bureau,Tongchuan 727000,China)
关键词:
慢性心力衰竭;  肌钙蛋白T;  N末端B型钠尿肽原;  临床意义;  相关性;  射血分数
Keywords:
Chronic heart failure;  Troponin T;  N-terminal pro-B-type natriuretic peptide;  Clinical significance;  Correlation;  Ejection fraction
分类号:
R 541.61
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.017
文献标志码:
A
摘要:
目的:分析不同类型慢性心力衰竭(CHF)患者血清肌钙蛋白T(TnT)、N末端B型钠尿肽原(NT-proBNP)水平变化及临床意义。方法:将208例CHF患者根据左心室射血分数(LVEF)分为HFREF组[射血分数降低型(LVEF<40%)心力衰竭,79例]、HFMREF组[射血分数中间范围型(40%≤LVEF<50%)心力衰竭,57例]与HFPEF组[射血分数保留型(LVEF≥50%)心力衰竭,72例]。比较三组患者血清TnT、NT-proBNP水平。采用Spearman法分析CHF患者血清TnT、NT-proBNP水平与LVEF相关性。比较不同类型心力衰竭患者随访3个月内心血管不良事件发生情况,并以发生与否作为预后评估标准将其分为预后良好组及预后不良组,比较其血清TnT、NT-proBNP水平。分析不同类型心力衰竭患者血清TnT、NT-proBNP水平与预后的关系。结果:不同类型CHF患者血清TnT、NT-proBNP水平比较,差异有统计学意义(均P<0.05)。血清TnT、NT-proBNP水平与CHF患者LVEF均呈明显负相关(均P<0.05)。HFMREF组及HFPEF组心血管不良事件总发生率低于HFREF组(均P<0.05)。不同类型CHF患者预后良好组与预后不良组血清TnT、NT-proBNP水平比较,差异有统计学意义(均P<0.05)。HFREF患者预后与血清TnT、NT-proBNP水平呈明显正相关(均P<0.05),HFMREF及HFPEF患者预后与血清TnT、NT-proBNP水平无相关性(均P>0.05)。结论:CHF患者血清TnT、NT-proBNP水平上升并与LVEF呈负相关,可作为射血分数降低型心力衰竭患者预后的评估指标。
Abstract:
Objective:To analyze the changes and clinical significance of serum troponin T(TnT)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)levels in patients with different types of chronic heart failure(CHF).Methods:According to the left ventricular ejection fraction(LVEF),208 patients with chronic heart failure(CHF)were divided into HFREF group [heart failure with reduced ejection fraction(LVEF<40%),79 cases],HFMREF group [heart failure with middle reduced ejection fraction(40%≤LVEF<50%),57 cases] and HFPEF group [heart failure with preserved ejection fraction(LVEF≥50%),72 cases].The levels of serum TnT and NT-proBNP were compared among the three groups.Spearman correlation analysis was used to analyze the correlation between levels of serum TnT,NT-proBNP and LVEF in patients with CHF.The occurrence of adverse cardiovascular events were compared among patients with different types of CHF within 3 months of follow-up,and the patients were divided into good prognosis group and poor prognosis group based on whether adverse cardiovascular events occurred or not,and the levels of serum TnT and NT-proBNP were compared.Spearman correlation analysis was used to analyze the relationship between levels of serum TnT,NT-proBNP and prognosis in patients with different types of CHF.Results:The differences in comparison of serum TnT and NT-proBNP levels were statistically significant among patients with different types of CHF(all P<0.05).Spearman correlation analysis showed that the levels of serum TnT and NT-proBNP were significantly negatively correlated with LVEF in patients with CHF(all P<0.05).The incidence rate of adverse cardiovascular events in HFMREF group and HFPEF group was significantly lower than that of HFREF group(all P<0.05).There were statistically significant differences in the levels of serum TnT and NT-proBNP between good prognosis group and poor prognosis group of patients with different types of CHF(all P<0.05).Spearman correlation analysis showed that the prognosis of patients with HFREF was significantly positively correlated with the levels of serum TnT and NT-proBNP(all P<0.05),and the prognosis of patients with HFMREF or HFPEF was not correlated with the levels of serum TnT and NT-proBNP(all P>0.05).Conclusion:Serum TnT and NT-proBNP levels in CHF patients increase and are negatively correlated with LVEF,which can be used as prognostic indicators for heart failure patients with reduced ejection fraction.

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备注/Memo

备注/Memo:
基金项目:陕西省科技计划项目(2020SF-192)
更新日期/Last Update: 2021-09-06