[1]于 铭,李 静,全守东,等.过敏性紫癜患儿不同时期血清促炎细胞因子水平变化及检测价值[J].陕西医学杂志,2021,50(9):1106-1108,1113.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.016]
　YU Ming,LI Jing,QUAN Shoudong,et al.Changes of serum pro-inflammatory cytokine levels in children with Henoch-Schonlein purpura in different periods and its detection value[J].,2021,50(9):1106-1108,1113.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.016]
点击复制

过敏性紫癜患儿不同时期血清促炎细胞因子水平变化及检测价值
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1106-1108,1113
栏目:
临床研究
出版日期:
2021-09-05

文章信息/Info

Title:
Changes of serum pro-inflammatory cytokine levels in children with Henoch-Schonlein purpura in different periods and its detection value
作者:
于 铭1; 2; 李 静1; 全守东2; 丁殿帅2
(1.锦州医科大学附属第一医院儿科,辽宁 锦州 121001; 2.朝阳市第二医院儿科,辽宁 朝阳 122000)
Author(s):
YU Ming; LI Jing; QUAN Shoudong; DING Dianshuai
(Department of Pediatrics,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
过敏性紫癜;  白细胞介素;  C反应蛋白;  肿瘤坏死因子-α;  检测价值
Keywords:
Henoch-Schonlein purpura;  Interleukin;  C-reactive protein;  Tumor necrosis factor-α;  Detection value
分类号:
R 554.6
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.016
文献标志码:
A
摘要:
目的:探讨过敏性紫癜患儿不同时期血清促炎细胞因子水平变化及检测价值。方法:选取过敏性紫癜患儿65例作为研究组。选取同期进行体检的健康儿童65例作为对照组。对研究组患儿急性期、恢复期以及对照组儿童血清促炎细胞因子[白细胞介素-2(IL-2)、IL-6、IL-33、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)]水平进行检测。比较研究组患儿急性期、恢复期与对照组血清IL-2、IL-6、IL-33、CRP、TNF-α水平变化,分析它们与过敏性紫癜患儿预后的关系。结果:研究组患儿急性期血清IL-2、IL-6、IL-33、CRP、TNF-α水平明显高于对照组(均P<0.05)。研究组患儿恢复期血清IL-2、IL-6、IL-33、CRP、TNF-α水平与对照组比较,差异无统计学意义(均P>0.05)。Logistic回归分析结果显示,血清IL-2、IL-6、IL-33、CRP、TNF-α水平与过敏性紫癜患儿预后相关,在小儿过敏性紫癜发病过程中具有独立作用(均P<0.05)。Pearson相关性分析显示,血清IL-2、IL-6、IL-33、CRP与TNF-α呈正相关(r=0.285、0.596、0.287、0.556,均P<0.001)。结论:血清IL-2、IL-6、IL-33、CRP、TNF-α参与了过敏性紫癜发病及免疫机制,急性期升高,恢复期下降,对患儿病情严重程度及预后评估具有重要价值。
Abstract:
Objective:To investigate the changes of serum pro-inflammatory cytokine levels in children with Henoch-Schonlein purpura in different periods and its detection value.Methods:65 cases of children with Henoch-Schonlein purpura were selected as the study group,and 65 cases of healthy children who underwent health examination in the same period were selected as the control group.The levels of serum pro-inflammatory cytokines [interleukin-2(IL-2),IL-6,IL-33,C-reactive protein(CRP)and tumor necrosis factor- α(TNF-α)] were detected.The changes in serum levels of IL-2,IL-6,IL-33,CRP,and TNF-α during the acute phase and recovery phase in the study group were compared with those in the control group,and their relationship with the prognosis of children with Henoch-Schonlein purpura was analyzed.Results:The levels of serum IL-2,IL-6,IL-33,CRP,and TNF-α during the acute phase in the study group were significantly higher than those in the control group(all P<0.05).The serum levels of IL-2,IL-6,IL-33,CRP and TNF-α during the recovery period in the study group were not significantly different from those in the control group(all P>0.05).Logistic regression analysis showed that serum levels of IL-2,IL-6,IL-33,CRP,and TNF-α were related to the prognosis of children with Henoch-Schonlein purpura,and have an independent role in the pathogenesis of children with Henoch-Schonlein purpura(all P<0.05).Pearson correlation analysis showed that serum IL-2,IL-6,IL-33,CRP were positively correlated with TNF-α(r=0.285,0.596,0.287,0.556,all P<0.001).Conclusion:Serum IL-2,IL-6,IL-33,CRP,and TNF-α participate in the pathogenesis and immune mechanism of Henoch-Schonlein purpura,increase in acute stage and decrease in recover stage,and have important value for the evaluation of the severity of the disease and the prognosis of children.

参考文献/References:

[1] Reid AJ.Henoch-Schonlein purpura nephritis in children:Incidence,pathogenesis and management[J].Pediatr Rev,2019,35(12):447-449.
[2] 雷 蕾,周 霖,蔡 斌,等.儿童过敏性紫癜91例临床分析[J].第二军医大学学报,2018,39(5):504-509.
[3] Hetland LE,Susrud KS,Lindahl KH,et al.Henoch-Schonlein purpura:A literature review[J].Acta Derm Venereol,2019,97(10):1160-1166.
[4] 刘娜娜,丁周志,陈 琼,等.过敏性紫癜患儿总IgE、IgA及补体C3水平对疾病预后的预测价值[J].中华全科医学,2019,17(9):1463-1466.
[5] Trnka P.Henoch-Schonlein purpura in children[J].J Paediatr Child Health,2019,49(12):995-1003.
[6] 田洪民,王淑屏,王鸿雁.过敏性紫癜患儿及紫癜性肾炎患儿血清炎症因子水平变化及意义[J].中国临床药理学杂志,2020,36(15):2189-2192.
[7] 中华医学会儿科学分会肾脏学组.紫癜性肾炎诊治循证指南(2016)[J].中华儿科杂志,2017,55(9):647-651.
[8] 余阳华,黄昊苏,龙禛朴,等.腹型过敏性紫癜45例临床分析[J].中国普通外科杂志,2020,29(4):466-472.
[9] 李 莉.儿童紫癜性肾炎治疗进展[J].中国社区医师,2020,36(24):4-5.
[10] 路桂杰,乐 婷,郭海云,等.白介素-6和降钙素原的动态变化对急诊老年脓毒性休克患者预后的评估意义[J].中国急救复苏与灾害医学杂志,2017,12(4):321-323.
[11] 赵琪楠.过敏性紫癜患者血清IL-10、IL-17、IL-23及TGF-β1的变化及意义[D].湛江:广东医科大学,2017.
[12] 肖艳美,戴 芳,董小伟,等.白介素33和S-100蛋白在过敏性紫癜肾炎儿童血清中的表达及意义[J].中国临床医生杂志,2017,45(8):100-102.
[13] 田红妮,马苗苗.中医辨证联合西医治疗儿童过敏性紫癜的临床疗效及对血清中IL-6、IL-8、IL-12、IL-18的影响研究[J].贵州医药,2020,44(11):1696-1698.
[14] 曹 莉,张 娟.血清超敏C反应蛋白检测在诊断小儿过敏性紫癜中的应用价值[J].当代医药论丛,2019,17(15):89-91.
[15] 乐高钟,吴小秧,吴志坚,等.血清PCT联合CRP检测在儿童过敏性紫癜中的临床意义[J].检验医学与临床,2019,16(6):752-754.
[16] 郑志方,陈国利,孙 鹏.过敏性紫癜患儿临床特点分析及白介素6、C反应蛋白水平的变化[J].河北医学,2019,25(2):262-265.
[17] 陈祥云,邱彩玲,张志玲,等.过敏性紫癜患儿血清CRP、IL-21及TNF-α的水平变化及临床应用价值分析[J].中国医学创新,2020,17(7):56-59.
[18] 魏艳蕾,卜文姬.过敏性紫癜患儿血清IL-13Ra2与(IL)-4,-6,-8及TNF-α的相关性及其临床意义分析[J].医学检验与临床,2019,30(3):52-55.
[19] 金 莉,曹经江.儿童过敏性紫癜治疗进展[J].中国麻风皮肤病杂志,2020,36(6):382-384.
[20] 杜春燕.过敏性紫癜临床表现及相关危险因素分析[J].母婴世界,2020,18(10):251.
[21] 闫 平,姚晓燕,任翠铮,等.中西医结合治疗小儿过敏性紫癜肾炎30例[J].陕西中医,2015,36(2):162-164.
[22] 柏 进,杨 娟,韩雪花.过敏性紫癜患儿免疫功能的临床观察[J].陕西医学杂志,2010,39(12):1663-1664,1667.

相似文献/References:

[1]王晓亮,赵光宇.过敏性紫癜患儿血清基质金属蛋白酶-13、白细胞介素-9和肿瘤坏死因子-α表达水平变化及意义[J].陕西医学杂志,2022,51(1):92.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.024]
　WANG Xiaoliang,ZHAO Guangyu.Changes and significance of serum MMP-13,IL-9 and TNF-α levelsin children with Henoch-Schonlein purpura[J].,2022,51(9):92.[doi:DOI:10.3969/j.issn.1000-7377.2022.01.024]
[2]刘锋锋,郑建杰,刘淼淼.体外膜肺氧合治疗对成人暴发性心肌炎患者细胞因子表达谱的影响[J].陕西医学杂志,2022,51(4):429.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.010]
　LIU Fengfeng,ZHENG Jianjie,LIU Miaomiao.Influence of extracorporeal membrane oxygenation therapy on cytokine expression profile in adult patient with fulminant myocarditis[J].,2022,51(9):429.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.010]
[3]党美佳,张小用,李 静.细胞因子在新生血管性年龄相关性黄斑变性中的作用研究进展[J].陕西医学杂志,2022,51(9):1174.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.031]
　DANG Meijia,ZHANG Xiaoyong,LI Jing.Research progress on role of cytokines in neovascular age-related macular degeneration[J].,2022,51(9):1174.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.031]
[4]李 根,马 翠.过敏性紫癜患儿外周血微小RNA-155、Toll样受体2、Toll样受体4、氧化应激指标表达水平与Th17/Treg平衡的关系[J].陕西医学杂志,2023,52(3):301.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.012]
　LI Gen,MA Cui.Relationship between expression levels of miR-155,TLR2,TLR4,oxidative stress and Th17/Treg balance in peripheral blood of children with anaphylactoid purpura[J].,2023,52(9):301.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.012]
[5]刘丽莹,朱 影,毛国顺,等.过敏性紫癜患儿预后影响因素及其预测价值研究[J].陕西医学杂志,2024,(3):382.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.020]
　LIU Liying,ZHU Ying,MAO Guoshun,et al.Prognostic influencing factors and their predictive value of children with Henoch-Schnlein purpura[J].,2024,(9):382.[doi:DOI:10.3969/j.issn.1000-7377.2024.03.020]
[6]王爱琳,潘 靓,张金秀,等.可溶性血管细胞黏附分子-1、中性粒细胞与淋巴细胞比值在过敏性紫癜患儿血清中的变化及检测意义[J].陕西医学杂志,2024,(8):1073.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.014]
　WANG Ailin,PAN Liang,ZHANG Jinxiu,et al.Changes of soluble vascular cell adhesion molecule-1 and neutrophil-to-lymphocyte ratio in the serum of children with Henoch-Schnlein purpura and their significance[J].,2024,(9):1073.[doi:DOI:10.3969/j.issn.1000-7377.2024.08.014]

备注/Memo

备注/Memo:
基金项目:辽宁省科学技术计划项目(20180551155)
更新日期/Last Update: 2021-09-06