[1]单兆亚,王 波.右美托咪定调控急性痛风性关节炎模型大鼠血清炎性因子水平及滑膜功能效果研究[J].陕西医学杂志,2021,50(9):1052-1055.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.003]
　SHAN Zhaoya,WANG Bo.Effect of dexmedetomidine on regulating serum inflammatory factors and synovial function in rats with acute gouty arthritis[J].,2021,50(9):1052-1055.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.003]
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右美托咪定调控急性痛风性关节炎模型大鼠血清炎性因子水平及滑膜功能效果研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年9期
页码:
1052-1055
栏目:
基础研究
出版日期:
2021-09-05

文章信息/Info

Title:
Effect of dexmedetomidine on regulating serum inflammatory factors and synovial function in rats with acute gouty arthritis
作者:
单兆亚1; 王 波2
(1.陕西中医药大学附属医院麻醉科,陕西 咸阳 712000; 2.宝鸡市中医医院麻醉科,陕西 宝鸡 721000)
Author(s):
SHAN Zhaoya; WANG Bo
(Department of Anesthesiology,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
关键词:
急性痛风性关节炎;  右美托咪定;  大鼠;  炎性因子;  滑膜功能;  足跖容积;  踝关节肿胀度
Keywords:
Acute gouty arthritis;  Dexmedetomidine;  Rats;  Inflammatory factors;  Synovial function;  Foot and plantar volume;  Ankle joint swelling
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.09.003
文献标志码:
A
摘要:
目的:探讨右美托咪定调控急性痛风性关节炎模型大鼠血清炎性因子水平及滑膜功能的效果。方法:将36只急性痛风性关节炎模型大鼠平分为模型组、秋水仙碱组与右美托咪定组,分别给予1 mg/kg 0.9%氯化钠溶液、1 mg/kg秋水仙碱与1 mg/kg盐酸右美托咪定灌胃,1次/d,连用14 d。检测血清炎性因子及滑膜功能变化情况。结果:秋水仙碱组与右美托咪定组治疗第7、14天足跖容积和踝关节肿胀度低于模型组,且右美托咪定组低于秋水仙碱组(均P<0.05)。秋水仙碱组与右美托咪定组治疗第14天滑膜组织尿酸(UA)、C-反应蛋白(CRP)含量与血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)含量均低于模型组,且右美托咪定组低于秋水仙碱组(均P<0.05)。结论:右美托咪定能够降低急性痛风性关节炎模型大鼠足跖容积与踝关节肿胀度,可抑制UA和CRP释放,也可抑制IL-1β和TNF-α表达。
Abstract:
Objective:To investigate the effect of dexmedetomidine on regulating serum inflammatory factors and synovial function in rats with acute gouty arthritis.Methods:36 rats with acute gouty arthritis model were equally divided into model group,colchicine group and dexmedetomidine group,and given 1 mg/kg normal saline,1 mg/kg colchicine and 1 mg/kg dexmedetomidine by gavage in turn,once a day for 14 days.The changes in serum inflammatory factors and synovial function was detected.Results:The foot plantar volume and ankle joint swelling of the colchicine group and the dexmedetomidine group on the 7th and 14th day of treatment were lower than those of the model group,and the dexmedetomidine group were lower than the colchicine group(all P<0.05).The levels of uric acid(UA)and C-reactive protein(CRP)in synovial tissue and the levels of serum interleukin(IL)-1β and tumor necrosis factor(TNF)-α in the colchicine group and the dexmedetomidine group on the 14th day of treatment were lower than those of the model group,and the dexmedetomidine group were lower than the colchicine group(all P<0.05).Conclusion:Dexmedetomidine can reduce the foot plantar volume and ankle joint swelling of rats with acute gouty arthritis,inhibit the release of UA and CRP,and also inhibit IL-1β and TNF-α expression.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81860213)
更新日期/Last Update: 2021-09-06