[1]李秀华,唐冬梅,朱丽萍,等.三阴性乳腺癌临床病理特征与基因分型研究[J].陕西医学杂志,2021,50(8):1015-1018.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.028]
　LI Xiuhua,TANG Dongmei,ZHU Liping,et al.Clinicopathological features and genotyping of triple negative breast cancer[J].,2021,50(8):1015-1018.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.028]
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三阴性乳腺癌临床病理特征与基因分型研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年8期
页码:
1015-1018
栏目:
临床病理
出版日期:
2021-08-05

文章信息/Info

Title:
Clinicopathological features and genotyping of triple negative breast cancer
作者:
李秀华; 唐冬梅; 朱丽萍; 董 楠; 李 甡
(锦州医科大学附属第一医院,辽宁 锦州 121001)
Author(s):
LI Xiuhua; TANG Dongmei; ZHU Liping; DONG Nan; LI Shen
(The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
三阴性乳腺癌;  临床病理特征;  基因表达亚型;  淋巴结转移;  乳头浸润;  预后
Keywords:
Triple negative breast cancer;  Clinicopathological characteristics;  Gene expression subtypes;  Lymphatic metastasis;  Nipple infiltration;  Prognosis
分类号:
R 737.9
DOI:
DOI:10.3969/j.issn.1000-7377.2021.08.028
文献标志码:
A
摘要:
目的:分析三阴性乳腺癌(TNBC)的临床病理特征,探讨TNBC基因分型的意义。方法:选取157例乳腺癌患者,根据雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER-2)检测结果将其分为观察组与对照组两组,比较其临床病理特征及生存差异,采用分子生物学技术对观察组患者作进一步的亚型分类,总结亚型分类的临床意义。结果:157例乳腺癌患者中,TNBC 38例(占24.2%),包括基底细胞样1型(BL1)、基底细胞样2型(BL2)、间质型(M)、间质干细胞样型(MSL)、免疫调节型(IM)和管腔雄激素受体型(LAR)六种基因表达亚型,以BL1、BL2为主; TNBC以浸润性导管癌为主,其淋巴结转移率、乳头浸润、TNM分期、病理分级均高于非三阴性乳腺癌,生存率明显低于非三阴性乳腺癌,差异均有统计学意义(均P<0.05)。结论:三阴乳腺癌基因突变大、异质性特殊、恶性程度高、预后差,探究其病理特征、做好基因分型有助于化解高危因素,做好预防工作,加强个体化治疗,改善预后。
Abstract:
Objective:To analyze the clinicopathological characteristics of triple negative breast cancer(TNBC),and to explore the significance of TNBC genotyping.Methods:157 breast cancer patients were selected and divided into observation group and control group according to the detection results of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER-2).Their clinicopathological characteristics and survival differences were compared.The molecular biology technique was used for further subtype classification of patients in the observation group,and the clinical significance of subtype classification was summarized.Results:Among 157 breast cancer patients,TNBC were 38 cases(24.2%),including six gene expression subtypes:basal cell-like type 1(BL1),basal cell-like type 2(BL2),mesenchymal type(M),mesenchymal stem cell-like type(MSL),immunomodulatory type(IM)and luminal androgen receptor type(LAR),mainly BL1 and BL2.TNBC was mainly invasive ductal carcinoma,its lymph node metastasis rate,nipple infiltration,TNM staging and pathological grade were higher than those of non-triple-negative breast cancer,and the survival rate was significantly lower than that of non-triple-negative breast cancer(all P<0.05).Conclusion:Triple negative breast cancer has large gene mutations,special heterogeneity,high degree of malignancy,and poor prognosis.Exploring its pathological characteristics and performing genotyping will help to resolve high-risk factors,do a good job in prevention,strengthen individualized treatment,and improve prognosis.

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备注/Memo

备注/Memo:
基金项目:辽宁省自然科学基金资助项目(201602281)
更新日期/Last Update: 2021-08-05