[1]张 燕.中性粒细胞淋巴细胞比值、血小板淋巴细胞比值在肺炎支原体感染患儿中的水平变化及临床意义[J].陕西医学杂志,2021,50(8):973-976.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.018]
　ZHANG Yan.Changes and significance of serum NLR and PLR level in children with mycoplasma pneumoniae infection[J].,2021,50(8):973-976.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.018]
点击复制

中性粒细胞淋巴细胞比值、血小板淋巴细胞比值在肺炎支原体感染患儿中的水平变化及临床意义
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年8期
页码:
973-976
栏目:
临床研究
出版日期:
2021-08-05

文章信息/Info

Title:
Changes and significance of serum NLR and PLR level in children with mycoplasma pneumoniae infection
作者:
张 燕
(西安市第一医院儿科,陕西 西安 710002)
Author(s):
ZHANG Yan
(Department of Pediatrics,Xi'an No.1 Hospital,Xi'an 710002,China)
关键词:
肺炎支原体;  感染;  诊断;  中性粒细胞淋巴细胞比值;  血小板淋巴细胞比值
Keywords:
Mycoplasma pneumoniae;  Infection;  Diagnosis;  Neutrophil-lymphocyte ratio;  Platelet-lymphocyte ratio
分类号:
R 725.5
DOI:
DOI:10.3969/j.issn.1000-7377.2021.08.018
文献标志码:
A
摘要:
目的:探讨中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)在肺炎支原体(MP)感染患儿中的水平变化及意义。方法:277例呼吸道感染患儿作为观察组,收集同期109例体检健康的患儿作为对照组。根据MP-IgM检测结果将观察组分为肺炎支原体抗体阳性组和肺炎支原体抗体阴性组。比较三组NLR、PLR表达水平,建立Logistic回归模型,制作ROC曲线评估NLR、PLR预测MP感染的价值。结果:①肺炎支原体抗体阳性组NLR、PLR水平明显高于肺炎支原体抗体阴性组及对照组,差异均有统计学意义(均P<0.05); ②Logistic 回归分析结果显示,NLR、PLR可预测肺炎支原体感染的风险(P<0.05); ③NLR、PLR单独检测及联合检测的ROC曲线下面积分别为0.709、0.683、0.717; NLR、PLR曲线下临界值为1.56、100.17,灵敏度53.3%、64.5%,特异度为82.5%、67.7%,两者联合检测的灵敏度69.8%,特异度70.96%。结论:NLR、PLR与MP感染密切相关,联合检测可提高对MP感染的预测效能,可给MP感染的诊断和治疗提供新线索。
Abstract:
Objective:To investigate the changes and significance of serum neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLT)in the children with mycoplasma pneumoniae infection.Methods:277 patients were selected as the observation group,and 109 children with healthy physical examination were selected as the control group.According to the MP-IgM detection result,the children in observation group were divided into mycoplasma pneumoniae positive group and mycoplasma pneumoniae negative group.The differences in NLR and PLR were compared among three groups.Logistic regression modle was established,and the ROC curve was used to evaluate the predict value of NLR and PLR in mycoplasma pneumoniae infection.Results:The serum NLR and PLR levels in mycoplasma pneumoniae positive group were significantly higher than those in mycoplasma pneumoniae negative group and control group(all P<0.05).Logistic regression analysis showed that NLR and PLR could predict the risk of mycoplasma pneumoniae infection(P<0.05).The AUC of NLR and PLR alone detection and combined detection were 0.709,0.683,0.717,respectively; the critical values under the NLR and PLR curves were 1.56 and 100.17,the sensitivity were 53.3% and 64.5%,the specificity were 82.5% and 67.7%.The sensitivity of the combined detection was 69.8%,and the specificity was 70.96%.Conclusion:NLR and PLR are closely related to the infection of mycoplasma pneumonia,combined detection can improve the predict efficacy of mycoplasma pneumoniae infection,and may provide new clues to the diagnosis and treatment.

参考文献/References:

[1] 周沛然,张兴益,冉沁宸,等.全身炎症反应和氧化应激指标在肺炎支原体感染患儿中的水平变化及其意义[J].中华医院感染学杂志,2020,30(20):3165-3169.
[2] 倪彩君,徐 芳,潘小明.儿童肺炎支原体感染中免疫功能及抗炎、促炎因子的检测分析[J].中国卫生检验杂志,2018,28(14):1747-1749,1756.
[3] 王纯花,王翠萍,冯娇梅.维生素A水平与儿童肺炎支原体感染的关系研究[J].中国医师杂志,2018,20(10):1551-1553.
[4] Kim JH,Kim JY,Yoo CH,et al.Macrolide resistance and its impacts on M.pneumoniae pneumonia in children:Comparison of two recent epidemics in Korea[J].Allergy Asthma Immunol Res,2017,9(4):340-346.
[5] 李 萌,姚 莉,王 菁,等.NLR、PLR在评估重症肺炎患者预后中的价值[J].安徽医学,2020,41(4):463-466.
[6] 俞怡雪,张芙荣,范玉洁,等.NLR和PLR在肺炎支原体肺炎患儿中的意义[J].中国妇幼保健,2019,34(19):4467-4470.
[7] 严建新,黄林瑶,江 天.成人甲型流感病毒初筛阳性患者中性粒细胞/淋巴细胞比值、淋巴细胞/单核细胞比值、血小板/淋巴细胞比值测定的临床意义[J].中国卫生检验杂志,2020,30(17):2148-2150,2153.
[8] 张永娟,昝丽娜,孙 峰,等.NLR和CRP在疱疹性咽峡炎合并肺炎支原体感染患儿中的应用价值[J].检验医学,2020,35(5):458-460.
[9] 张志颖,张 翔,赵云红,等.遵义地区2014—2019年儿童肺炎支原体感染现状[J].中国学校卫生,2020,41(10):1566-1568.
[10] 阳爱梅,宋建辉,黄 榕,等.1026例儿童肺炎支原体感染及耐药情况分析[J].中国当代儿科杂志,2013,15(7):522-525.
[11] 归巧娣,施瑞洁,张向阳,等.西安地区2837例儿童肺炎支原体感染及耐药调查研究[J].陕西医学杂志,2018,47(2):265-267.
[12] 孔慧霞.肺炎支原体感染对儿童肺功能的影响及与慢性咳嗽的关系[J].医药论坛杂志,2020,41(9):70-72,76.
[13] 罗 皓.ALBI分级联合NLR对肝癌术后预后临床价值的研究[D].泸州:西南医科大学,2020.
[14] 石婵娟.中性粒细胞/淋巴细胞比值与冠心病心衰患者心衰严重程度及预后的相关性分析[D].衡阳:南华大学,2020.
[15] 董远峰,彭 晶,陈艳炯.中性粒细胞淋巴细胞比值和血小板淋巴细胞比值在慢性乙肝患者外周血中的变化及其临床意义[J].陕西医学杂志,2020,49(9):1178-1181.
[16] 时 光,赵俊伟,明 亮.哮喘患者外周血血小板-淋巴细胞比值和中性粒细胞-淋巴细胞比值的临床意义[J].南方医科大学学报,2017,37(1):84-88.
[17] 彭成勇.血小板计数、平均血小板体积与D-二聚体水平变化在重症肺炎患者诊断中的意义探讨[J].吉林医学,2017,38(4):676-677.
[18] 江贵军,吕菁君.血小板活化及其相关免疫反应在脓毒症中的作用[J].中国感染控制杂志,2019,18(3):271-276.
[19] 潘新峰.肺炎支原体感染后小儿血常规变化及临床意义分析[J].中国卫生标准管理,2020,11(8):110-112.
[20] 朱若尘,蒋 芹,吴良霞,等.肺炎支原体肺炎婴幼儿继发血小板增多症的临床特征及意义[J].临床儿科杂志,2017,35(2):86-89.

相似文献/References:

[1]贾 杉,加 莉△.外伤性脑出血患者术后感染病原菌分布特点及与炎症反应和氧化应激关系探讨[J].陕西医学杂志,2020,49(5):564.
　JIA Shan,JIA Li..Distribution of pathogenic bacteria in patients with traumatic cerebral hemorrhage after operation and expression of inflammatory stress index in serum[J].,2020,49(8):564.
[2]寇玉兰,李 莉,闫倚天,等.陕西安康市新型冠状病毒肺炎20例流行病学特点及临床干预策略[J].陕西医学杂志,2020,49(6):653.[doi:DOI:10.3969/j.issn.10007377.2020.06.003]
[3]马凯骅,郭明飞.腹腔镜手术术后脐部通道切口感染发生率及其危险因素分析[J].陕西医学杂志,2021,50(11):1375.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.013]
　MA Kaihua,GUO Mingfei.Incidence and risk factors of umbilical channel incision infection after laparoscopic surgery[J].,2021,50(8):1375.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.013]
[4]罗孔认,陈梦诗,陈珊娜.甲壳质酶蛋白40、中性粒细胞载脂蛋白及基质金属蛋白酶-9水平与尿毒症维持性血液透析患者感染相关性研究[J].陕西医学杂志,2023,52(10):1362.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]
　LUO Kongren,CHEN Mengshi,CHEN Shanna.Correlation of YKL-40,NGAL and MMP-9 levels with infection in uremic patients undergoing maintenance hemodialysis[J].,2023,52(8):1362.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.017]
[5]张海燕,唐 岚,廖春淑,等.急性白血病化疗后中性粒细胞缺乏合并感染患者临床特征及血清免疫因子检测临床意义[J].陕西医学杂志,2024,(2):239.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.020]
　ZHANG Haiyan,TANG Lan,LIAO Chunshu,et al.Clinical characteristics and clinical significance of serum immune factors in acute leukemia patients with post-chemotherapy neutropenia complicated with infection[J].,2024,(8):239.[doi:DOI:10.3969/j.issn.1000-7377.2024.02.020]
[6]梁建峰,程玉峰.支气管扩张合并感染患者血清降钙素原、C-反应蛋白和25-羟维生素D3变化及其临床检测价值研究[J].陕西医学杂志,2024,(5):688.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.025]
　LIANG Jianfeng,CHENG Yufeng.Changes of serum procalcitonin,C-reactive protein and 25-hydroxyvitamin D3 levels in patients with bronchiectasis combined with infection and their clinical value[J].,2024,(8):688.[doi:DOI:10.3969/j.issn.1000-7377.2024.05.025]
[7]李世平,范平平,吝新英.糖尿病酮症酸中毒合并感染患者血清微小RNA-146a和微小RNA-155水平检测及意义[J].陕西医学杂志,2024,(6):828.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.023]
　LI Shiping,FAN Pingping,LIN Xinying.Detection and significance of serum miR-146a and miR-155 levels in patients with diabetic ketoacidosis complicated with infection[J].,2024,(8):828.[doi:DOI:10.3969/j.issn.1000-7377.2024.06.023]
[8]朱 君,杨 毅.潜伏性结核分枝杆菌感染的䥺SymbolgA@干扰素释放试验、单核细胞表达水平及临床诊断价值研究[J].陕西医学杂志,2024,(7):974.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.024]
[9]刘维伟,王翠敏,刘平安,等.糖尿病足感染患者血清CXC趋化因子配体10和可溶性髓系细胞触发受体-1水平与病情、治疗效果的关系[J].陕西医学杂志,2025,54(3):349.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.012]
　LIU Weiwei,WANG Cuimin,LIU Ping'an,et al.Relationship between serum CXCL10,sTREM-1 levels and disease condition,therapeutic efficacy in patients with diabetic foot infection[J].,2025,54(8):349.[doi:DOI:10.3969/j.issn.1000-7377.2025.03.012]

备注/Memo

备注/Memo:
基金项目:西安市科技计划项目[20YXYJ0006(6)]
更新日期/Last Update: 2021-08-16