[1]谭玉成,徐建庆.腹腔镜根治术对胃癌患者肿瘤标志物及氧化应激水平的影响[J].陕西医学杂志,2021,50(8):969-972.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.017]
　TAN Yucheng,XU Jianqing.Effect of laparoscopic radical operation on tumor markers and oxidative stress in patients with gastric cancer[J].,2021,50(8):969-972.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.017]
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腹腔镜根治术对胃癌患者肿瘤标志物及氧化应激水平的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年8期
页码:
969-972
栏目:
临床研究
出版日期:
2021-08-05

文章信息/Info

Title:
Effect of laparoscopic radical operation on tumor markers and oxidative stress in patients with gastric cancer
作者:
谭玉成1; 徐建庆2
(1.辽宁省健康产业集团抚矿总医院普外科,辽宁 抚顺 113007; 2.西安高新医院,陕西 西安 710075)
Author(s):
TAN Yucheng; XU Jianqing
(Department of General Surgery,Fukuang General Hospital,Liaoning Health Industry Group,Fushun 113007,China)
关键词:
胃癌;  腹腔镜;  根治手术;  肿瘤标志物;  氧化应激
Keywords:
Gastric cancer;  Laparoscopy;  Radical operation;  Tumor marker;  Oxidative stress
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.08.017
文献标志码:
A
摘要:
目的:探讨腹腔镜根治术对胃癌患者肿瘤标志物及氧化应激水平的影响。方法:胃癌患者154例为研究对象,采用随机数字表法分为对照组(77例)和观察组(77例)。对照组采用开腹手术治疗,观察组采用腹腔镜根治术治疗,术后观察24 h,随访2年。统计两组手术情况,比较两组术前和术后24 h血清氧化应激指标、肿瘤标志物、炎性因子水平。结果:观察组术中出血量低于对照组(P<0.01),手术时间、排气时间、住院时间短于对照组(P<0.01)。与术前比较,术后24 h两组血清谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平降低,但观察组高于对照组(P<0.05)。与术前比较,术后24 h两组血清丙二醛(MDA)、白介素-2(IL-2)、C-反应蛋白(CRP)、可溶性白介素-2受体(SIL-2R)水平升高,但观察组低于对照组(P<0.05)。与术前比较,术后24 h两组血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原25(CA125)水平降低,观察组低于对照组(P<0.05)。观察组总有效率(92.21%)显著高于对照组(80.52%,P<0.05); 随访2年,观察组和对照组复发率(9.09%和11.69%)两组比较差异无统计学意义(P>0.05)。结论:腹腔镜根治术治疗胃癌患者,可有效降低患者血清CEA、CA199、CA125水平,清除肿瘤组织,且其对机体氧化应激和炎症反应的影响更小,同时术中出血量更少,有助于促进患者术后恢复,具有良好的治疗效果。
Abstract:
Objective:To analyze the effect of laparoscopic radical operation on tumor markers and oxidative stress in patients with gastric cancer.Methods:A total of 154 patients with gastric cancer were divided into the control group(77 cases)and the observation group(77 cases)by random number table method.The control group was treated with open surgery,and the observation group was treated with laparoscopic radical operation.They were observed for 24 hours after the operation and followed up for 2 years.The surgical conditions of the two groups were statistically analyzed,and the levels of serum oxidative stress indexes,tumor markers and inflammatory factors before and 24 hours after surgery were compared between the two groups.Results:The amount of intraoperative bleeding in the observation group was lower than that in the control group,and the operation time,exhaust time and hospitalization time were shorter than those in the control group(all P<0.01).The levels of serum glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in the two groups 24 hours after operation were lower than those before operation,and the observation group was higher than the control group(all P<0.05).The levels of serum malondialdehyde(MDA),interleukin-2(IL-2),C-reactive protein(CRP)and soluble interleukin-2 receptor(SIL-2R)in the two groups 24 hours after operation were higher than those before operation,and the observation group was lower than the control group(all P<0.05).The levels of serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 25(CA125)in the two groups 24 hours after operation were lower than those before operation,and the observation group was lower than the control group(all P<0.05).The total effective rate of observation group was significantly higher than that of control group(92.21% vs.80.52%,P<0.05).After 2 years of follow-up,there was no significant difference in the recurrence rate between the observation group and the control group(9.09% vs.11.69%,P>0.05).Conclusion:Laparoscopic radical surgery for patients with gastric cancer can effectively reduce the serum CEA,CA199 and CA125 levels,clear away tumor tissues,and has less influence on oxidative stress and inflammatory reaction,and can reduce the amount of intraoperative bleeding,which was helpful to promote postoperative recovery of patients,and has good therapeutic effect.

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更新日期/Last Update: 2021-08-05