[1]房 芹,白玉勤.甲状腺乳头状癌肿瘤出芽情况与临床病理特征相关性研究[J].陕西医学杂志,2021,50(7):882-885.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.030]
　FANG Qin,BAI Yuqin.Correlation between tumor budding and clinicopathological features of papillary thyroid carcinoma[J].,2021,50(7):882-885.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.030]
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甲状腺乳头状癌肿瘤出芽情况与临床病理特征相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年7期
页码:
882-885
栏目:
临床病理
出版日期:
2021-07-05

文章信息/Info

Title:
Correlation between tumor budding and clinicopathological features of papillary thyroid carcinoma
作者:
房 芹1; 2; 白玉勤1; 2
(1.锦州医科大学,辽宁 锦州121000; 2.赤峰学院附属医院,内蒙古 赤峰 024000)
Author(s):
FANG Qin; BAI Yuqin
(Jinzhou Medical University,Jinzhou 121000,China)
关键词:
甲状腺乳头状癌;  肿瘤出芽;  被膜侵犯;  淋巴结转移;  病理分期
Keywords:
Papillary thyroid carcinoma;  Tumor budding;  Membrane invasion;  Lymph node metastasis;  Pathological staging
分类号:
R 736.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.07.030
文献标志码:
A
摘要:
目的:探讨甲状腺乳头状癌的肿瘤出芽与临床病理特征相关性。方法:选取甲状腺癌乳头状癌患者319例,所有患者均行根治手术治疗。采用HE染色和免疫组化法,光镜下检测出甲状腺乳头状癌肿瘤出芽情况,其中肿瘤出芽患者为观察组,无出芽患者为对照组。研究出芽与否和临床病理特征关系。结果:①甲状腺乳头状癌出芽患者111例,出芽率为34.80%(111/319),无出芽患者208例,占65.20%(208/319)。②两组乳头状癌患者年龄、性别、肿瘤的直径大小、肿瘤的单双侧病灶等因素比较均无统计学差异(均P>0.05); 而有无被膜侵犯、是否发生淋巴结转移、病理分期、临床T分期以及是否侵犯周围神经等因素比较差异均有统计学意义(均P<0.05)。③观察组出芽的患者中,低出芽患者为56例,高出芽为55例,其中高出芽的患者发生被膜侵犯、有淋巴结转移、病理分期以及临床T分期大小明显高于低出芽患者,差异均有统计学意义(均P<0.05)。结论:甲状腺乳头状癌的肿瘤出芽与临床病理特征关系密切,甲状腺乳头状癌肿瘤有无出芽与年龄、性别、肿瘤的直径大小、肿瘤的单双侧病灶没有关系; 而与有无被膜侵犯、是否发生淋巴结转移、病理分期、临床T分期以及是否侵犯周围神经等因素有关,且高出芽肿瘤患者预后不及低出芽患者。此为今后临床工作者及早发现甲状腺乳头状癌预后打下基础。
Abstract:
Objective:To investigate the correlation between tumor budding and clinicopathological features of papillary thyroid carcinoma.Methods:A total of 319 patients with papillary thyroid carcinoma were selected,and all patients underwent radical surgery.Using HE staining and immunohistochemistry,the budding of papillary thyroid carcinoma was detected under light microscope.Among them,patients with tumor budding were in the observation group,and those without budding were in the control group.The relationship between budding or not and clinicopathological characteristics was studied.Results:The budding rate of papillary thyroid carcinoma was 34.80%.There were no significant differences in age,sex,diameter of tumor,single and bilateral lesions of carcinoma between the two groups(all P>0.05),but there were significant differences in membrane invasion,lymph node metastasis,pathological stage,clinical T stage and peripheral nerve invasion(all P<0.05).There were 56 patients with low budding and 55 patients with high budding in the observation group,and the membrane invasion,lymph node metastasis,pathological stage and clinical T stage in patients with high budding were significantly higher than those with low budding(all P<0.05).Conclusion:Tumor budding of papillary thyroid carcinoma is closely related to clinicopathological characteristics.The budding of papillary thyroid carcinoma is not related to age,sex,tumor diameter,and unilateral and bilateral tumors,but it is related to the presence or absence of membrane invasion,whether there is lymph node metastasis,pathological staging,clinical T stage,and whether it invades peripheral nerves,and the prognosis of patients with high budding is not as good as that of patients with low budding.This lays the foundation for the early detection of papillary thyroid carcinoma by clinicians in the future.

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备注/Memo

备注/Memo:
基金项目:内蒙古自治区教育厅科学研究项目(NJZZ18202)
更新日期/Last Update: 2021-07-05