[1]赵苗苗,吕朝治,余 玲.呼吸道不同血清型别腺病毒感染患儿\外周血T淋巴细胞亚群水平变化研究[J].陕西医学杂志,2021,50(7):878-881.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.029]
　ZHAO Miaomiao,LYU Chaozhi,YU Ling.Changes of T-lymphocyte subsets in peripheral blood of children with adenovirus infection of different serotypes in respiratory tract[J].,2021,50(7):878-881.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.029]
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呼吸道不同血清型别腺病毒感染患儿\外周血T淋巴细胞亚群水平变化研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年7期
页码:
878-881
栏目:
临床检验
出版日期:
2021-07-05

文章信息/Info

Title:
Changes of T-lymphocyte subsets in peripheral blood of children with adenovirus infection of different serotypes in respiratory tract
作者:
赵苗苗; 吕朝治; 余 玲
(汉中市中心医院儿科,陕西 汉中 723000)
Author(s):
ZHAO Miaomiao; LYU Chaozhi; YU Ling
(Department of Pediatrics,Hanzhong Central Hospital,Hanzhong 723000,China)
关键词:
腺病毒;  呼吸道感染;  血清型别;  T淋巴细胞;  儿童
Keywords:
Adenovirus;  Respiratory tract infection;  Serotypes;  T lymphocyte;  Children
分类号:
R 725.6
DOI:
DOI:10.3969/j.issn.1000-7377.2021.07.029
文献标志码:
A
摘要:
目的:探讨呼吸道不同血清型别腺病毒感染患儿外周血T淋巴细胞亚群水平的变化情况。方法:选取67例呼吸道腺病毒感染患儿(研究组),另选取同期53例体检健康儿童(对照组),均行外周血T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平检测。另对研究组毒株和(或)阳性标本行DNA提取,统计呼吸道腺病毒感染的不同血清型别,并分析各血清型别腺病毒感染患儿的外周血T淋巴细胞亚群水平变化情况。结果:研究组外周血CD3+、CD4+、CD4+/CD8+水平均较对照组降低,差异具有统计学意义(P<0.05); 研究组外周血CD8+水平与对照组比较,差异无统计学意义(P>0.05); 在67例呼吸道腺病毒感染患儿中,3型腺病毒35例(52.24%),7型腺病毒21例(31.34%),其他型腺病毒11例(16.42%); CD8+在研究组各血清型别间比较差异无统计学意义(均P>0.05); CD3+、CD4+、CD4+/CD8+在研究组各血清型别间比较有统计学差异(均P<0.05),3型、7型腺病毒感染患儿外周血CD3+、CD4+、CD4+/CD8+均低于其他型别腺病毒感染,7型腺病毒感染患儿CD3+、CD4+、CD4+/CD8+均低于3型腺病毒感染,差异均有统计学意义(均P<0.05)。结论:呼吸道腺病毒感染患儿外周血T淋巴细胞亚群中CD3+、CD4+、CD4+/CD8+水平均异常降低,其腺病毒感染型别以3型、7型为主,且3型、7型腺病毒感染患儿外周血CD3+、CD4+、CD4+/CD8+水平较其他型别下降明显,尤其是7型腺病毒感染降低最为严重。
Abstract:
Objective:To investigate the changes of T lymphocyte subsets in peripheral blood of children with adenovirus infection of different serotypes in respiratory tract.Methods:67 children with respiratory tract adenovirus infection were selected as study group,and the 53 healthy children during the same period were selected as control group.The levels of T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)in peripheral blood were detected.In addition,DNA were extracted from the virus strains and(or)positive samples of the study group,and different serotypes of respiratory tract adenovirus infection were counted,then the changes of T-lymphocyte subsets in peripheral blood of children with adenovirus infection of each serotypes were analyzed.Results:The peripheral blood CD3+,CD4+,CD4+/CD8+ levels of the study group were lower than those of the control group(all P<0.05).There was no significant difference in the level of CD8+ in peripheral blood between the study group and the control group(P>0.05).Among 67 children with respiratory tract adenovirus infection,there were 35 cases with adenovirus type 3(52.24%),and there were 21 cases with adenovirus type 7(31.34%),and other adenovirus types were 11 cases(16.42%).There was no significant difference in CD8+ level among serotypes in the study group(P>0.05).There were significant differences in CD3+,CD4+ and CD4+/CD8+ levels among serotypes in the study group(all P<0.05).The levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood of children infected with type 3 and 7 adenovirus were lower than those of other types adenovirus,of which the children infected with type 7 adenovirus were lower than those of the children infected with type 3 adenovirus(all P<0.05).Conclusion:The levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood T-lymphocyte subsets of children with respiratory tract adenovirus infection are abnormally reduced,and the main types of adenovirus infection are type 3 and type 7,and the levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood of children with type 3 and type 7 adenovirus infection are significantly lower than those of other types,especially type 7 adenovirus infection.

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更新日期/Last Update: 2021-07-05