[1]李丽容,卢治兰,邓向海,等.2型糖尿病患者并发缺血性脑卒中危险因素及与载脂蛋白E基因型相关性分析[J].陕西医学杂志,2021,50(6):723-725,730.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.021]
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2型糖尿病患者并发缺血性脑卒中危险因素及与载脂蛋白E基因型相关性分析
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年6期
页码:
723-725,730
栏目:
临床研究
出版日期:
2021-06-05

文章信息/Info

作者:
李丽容1卢治兰2邓向海1单林玲1
(1.安康市中医医院检验科,陕西 安康 725000; 2.安康市中医医院影像中心,陕西 安康 725000)
关键词:
2型糖尿病 缺血性脑卒中 危险因素 载脂蛋白E 基因型 高血压
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.06.021
文献标志码:
A
摘要:
目的:探讨2型糖尿病(T2DM)患者并发缺血性脑卒中危险因素及与载脂蛋白E(ApoE)基因型的相关性。方法:选择T2DM患者共490例,根据是否并发缺血性脑卒中分为A组(未并发缺血性脑卒中,355例)与B组(并发缺血性脑卒中,135例)。分析ApoE基因型,并采用单因素和多因素法评价T2DM患者并发缺血性脑卒中独立危险因素。结果:两组合并原发性高血压比例、收缩压、舒张压及低密度脂蛋白胆固醇(LDL-C)水平比较差异有统计学意义(均P<0.05)。B组ε2/ε3、ε3/ε4基因型频率及ε4基因频率显著高于A组,ε3/ε3基因型频率和ε3基因频率显著低于A组(均P<0.05)。Logistic回归模型多因素分析结果显示,合并原发性高血压、高收缩压、ApoE ε2/ε3和ε3/ε4基因型是T2DM患者并发缺血性脑卒中的独立危险因素(均P<0.05)。结论:合并原发性高血压、高收缩压、ApoE ε2/ε3和ε3/ε4基因型及T2DM患者更易并发缺血性脑卒中。早期评估ApoE基因型并给予针对性干预有助于降低缺血性脑卒中发生风险。

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更新日期/Last Update: 2021-06-07