[1]杨丽娟,郝小康,周 军.慢性乙型肝炎患者Toll样受体2与乙型肝炎病毒DNA表达水平相关性研究[J].陕西医学杂志,2021,50(6):697-700.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.014]
　YANG Lijuan,HAO Xiaokang,ZHOU Jun.Correlation between HBV-DNA and TLR2 levels in patients with chronic hepatitis B[J].,2021,50(6):697-700.[doi:DOI:10.3969/j.issn.1000-7377.2021.06.014]
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慢性乙型肝炎患者Toll样受体2与乙型肝炎病毒DNA表达水平相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年6期
页码:
697-700
栏目:
临床研究
出版日期:
2021-06-05

文章信息/Info

Title:
Correlation between HBV-DNA and TLR2 levels in patients with chronic hepatitis B
作者:
杨丽娟1; 郝小康2; 周 军1
(1.安康市人民医院检验科,陕西 安康 725000; 2.西藏民族大学附属医院检验科,陕西 咸阳 712082)
Author(s):
YANG Lijuan; HAO Xiaokang; ZHOU Jun
(Department of Laboratory Medicine,Ankang People's Hospital,Ankang 725000,China)
关键词:
慢性乙型肝炎;  Toll样受体2;  乙型肝炎病毒;  相关性;  乙型肝炎病毒DNA
Keywords:
Chronic hepatitis B;  Toll-like receptor 2;  Hepatitis B virus;  Correlation;  HBV-DNA
分类号:
R 512.6
DOI:
DOI:10.3969/j.issn.1000-7377.2021.06.014
文献标志码:
A
摘要:
目的:探讨慢性乙型肝炎(CHB)患者Toll样受体2(TLR2)与乙型肝炎病毒DNA(HBV-DNA)表达水平的相关性。方法:选择CHB患者123例为肝炎组,选择同期健康体检者123例为对照组。检测两组HBV-DNA与TLR2表达水平,以及肝功能指标[包括谷丙转氨酶(ALT)、谷草转氨酶(AST)、甲胎蛋白(AFP)、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)等]水平,并进行比较与相关性分析。结果:对照组无检出HBV-DNA,肝炎组均检出HBV-DNA。肝炎组TLR2相对表达水平高于对照组(P<0.05)。肝炎组ALT、AST、AFP、GGT、ALP高于对照组(均P<0.05)。在肝炎组中,Pearson相关性分析显示HBV-DNA水平与TLR2、ALT、AST、AFP、肝脏炎症病理分级、ALP存在相关性(均P<0.05)。Logistic回归分析显示TLR2、ALT、AST、AFP、肝脏炎症病理分级均为CHB患者HBV-DNA水平的影响因素(均P<0.05)。结论:CHB患者多伴有TLR2高表达,与HBV-DNA水平呈正相关,是影响CHB患者病情与肝功能的重要指标。
Abstract:
Objective:To explore the correlation between the levels of hepatitis B virus DNA(HBV-DNA)and Toll-like receptor 2(TLR2)in patients with chronic hepatitis B(CHB).Methods:123 cases of patients with CHB were selected as the hepatitis group,and 123 cases of healthy people who received physical examination were selected as the control group.HBV-DNA and TLR2 expression levels,as well as the levels of liver function indicators such as ALT,AST,AFP,GGT and ALP were detected and compared,and the correlation was analyzed.Results:No HBV-DNA was detected in the control group,and HBV-DNA was detected in the hepatitis group.The relative expression level of TLR2 in the hepatitis group was higher than that in the control group(P<0.05).The levels of ALT,AST,AFP,GGT,and ALP in the hepatitis group were higher than those in the control group(all P<0.05).In the hepatitis group,Pearson correlation analysis showed that HBV-DNA levels were correlated with TLR2,ALT,AST,AFP,liver inflammation pathological grade,and ALP(all P<0.05).Logistic regression analysis showed that TLR2,ALT,AST,AFP,and liver inflammation pathological grade were influencing factors of HBV-DNA level in CHB patients(all P<0.05).Conclusion:CHB patients are mostly accompanied by high expression level of TLR2,which is positively correlated with the level of HBV-DNA,and is an important indicator that affects the condition and liver function of CHB patients.

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备注/Memo

备注/Memo:
基金项目:西藏自治区自然科学基金资助项目[XZ2019ZRG-31(Z)]
更新日期/Last Update: 2021-06-07