[1]买赛虎,徐建庆,张站产.基质金属蛋白酶-2、CD34标记微血管密度在胆囊癌组织中的表达及临床意义[J].陕西医学杂志,2021,50(5):622-625.[doi:DOI:10.3969/j.issn.1000-7377.2021.05.027]
　MAI Saihu,XU Jianqing,ZHANG Zhanchan.Expression and clinical significance of MMP-2 and CD34-MVD in gallbladder carcinoma[J].,2021,50(5):622-625.[doi:DOI:10.3969/j.issn.1000-7377.2021.05.027]
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基质金属蛋白酶-2、CD34标记微血管密度在胆囊癌组织中的表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年5期
页码:
622-625
栏目:
临床病理
出版日期:
2021-05-05

文章信息/Info

Title:
Expression and clinical significance of MMP-2 and CD34-MVD in gallbladder carcinoma
作者:
买赛虎; 徐建庆; 张站产
(西安高新医院普外科,陕西 西安710075)
Author(s):
MAI Saihu; XU Jianqing; ZHANG Zhanchan
(Department of Genenal Surgery,Gaoxin Hospital,Xi'an 710075,China)
关键词:
基质金属蛋白酶-2;  CD34标记微血管密度;  胆囊癌;  免疫组化;  临床病理特征
Keywords:
Matrix metalloproteinase-2;  CD34-MVD;  Gallbladder carcinoma;  Immunohistochemistry;  Clinical pathological characteristicr
分类号:
R 735.8
DOI:
DOI:10.3969/j.issn.1000-7377.2021.05.027
文献标志码:
A
摘要:
目的:研究基质金属蛋白酶-2(MMP-2)及CD34标记微血管密度(CD34-MVD)在胆囊癌中组织的表达水平及两者的相关性。方法:应用免疫组织化学的方法检测52例胆囊癌和25例慢性胆囊炎组织中MMP-2、CD34-MVD的表达,并探讨两者的表达与胆囊癌临床特征的关系。结果:MMP-2在胆囊癌和慢性胆囊炎中表达比较差异有统计学意义(P<0.05),其中在慢性胆囊炎组织阳性表达率为24.0%(6/25),在胆囊癌组织中阳性表达率为78.8%(41/52); CD34-MVD在胆囊癌为(53.6±8.9),慢性胆囊炎为(19.6±4.15),两者之间表达水平比较有统计学差异(P<0.05)。MMP-2、CD34-MVD在胆囊癌中的表达呈正相关(r=1.3794,P=0.0062)。结论:在胆囊癌组织中MMP-2及CD34-MVD高表达,在胆囊癌判断上具有一致性,两者可能促进胆囊癌的发生、发展、侵袭及转移。
Abstract:
Objective:To investigate the expression levels of MMP-2,CD34-MVD in gallbladder carcinoma(GC)and their correlation.Methods:The expression levels of MMP-2 and CD34-MVD were detected by Immunohistochemistry in 52 cases of gallbladder carcinoma tissues and 25 cases of chronic cholecystitis tissues.The relationship between their expression and the clinical pathological characteristics were analyzed.Results:The expression level of MMP-2 in gallbladder carcinoma and chronic cholecystitis tissues were significantly different(P<0.05).The positive rate of MMP-2 was markedly in gallbladder carcinoma tissue(41/52),more than that in chronic cholecystitis tissue(78.8% vs.24.0%,P<0.05).The expression level of CD34-MVD was(53.6±8.9)in gallbladder cancer and(19.6±4.15)in chronic cholecystitis,and there was statistical difference between the two(P<0.05).The expression of MMP-2 and CD34-MVD in gallbladder cancer was positively correlated(r=1.3794,P=0.0062).Conclusion:MMP-2 and CD34-MVD are highly expressed in gallbladder cancer tissues,and they are consistent in the judgment of gallbladder cancer.The two may promote the occurrence,development,invasion and metastasis of gallbladder cancer.

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更新日期/Last Update: 2021-05-06