[1]陈正浤,李媛媛,雷光焰,等.Ⅰ型分裂蛋白转导素样增强子在肿瘤中的作用研究进展[J].陕西医学杂志,2021,50(4):511-封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.034]
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Ⅰ型分裂蛋白转导素样增强子在肿瘤中的作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年4期
页码:
511-封3
栏目:
综述
出版日期:
2021-04-05

文章信息/Info

作者:
陈正浤1李媛媛2雷光焰3李 宏4周智辉2
(1.陕西中医药大学,陕西 咸阳 712046; 2.陕西中医药大学第二附属医院科研科,陕西 咸阳712046; 3.陕西省肿瘤医院胸外科,陕西 西安 710061; 4.陕西中医药大学制药厂,陕西 咸阳 712000)
关键词:
Ⅰ型分裂蛋白转导素样增强子 转录共抑制因子 肿瘤 促肿瘤因子 肿瘤抑制因子 诊断标志物
分类号:
R 73
DOI:
DOI:10.3969/j.issn.1000-7377.2021.04.034
文献标志码:
A
摘要:
Ⅰ型分裂蛋白转导素样增强子(TLE1)是转录共抑制因子Groucho(Gro)/TLE基因家族成员。TLE1蛋白通过介导细胞的分化和发育,在胚胎发育、造血细胞发育分化、神经发生以及多种恶性肿瘤发生与发展过程中起着重要作用。TLE1作为重要转录因子,在不同肿瘤中作用不同,可能是促肿瘤因子(如在肺癌、乳腺癌、胃癌),也可能是肿瘤抑制因子(如在肝癌、白血病),参与调节细胞增殖、凋亡、转移等过程。TLE1可作为潜在的诊断标志物(尤其是滑膜肉瘤)和治疗靶点。现就TLE1在肿瘤中的主要作用与最新研究进展作简要综述。

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基础研究计划项目(2019JQ-871,2019JM-224); 陕西省科协企业创新争先青年人才托举计划项目(20190303); 陕西中医药大学学科创新团队项目(2019-YS03)
更新日期/Last Update: 2021-04-06