[1]姜金波,吴 迪,刘文明,等.精神分裂症幻听的磁共振成像研究进展[J].陕西医学杂志,2021,50(4):507-510，封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.033]
　JIANG Jinbo,WU Di,LIU Wenming,et al.Research progress of magnetic resonance imagingon auditory hallucinations in schizophrenia[J].,2021,50(4):507-510，封3.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.033]
点击复制

精神分裂症幻听的磁共振成像研究进展
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年4期
页码:
507-510，封3
栏目:
出版日期:
2021-04-05

文章信息/Info

Title:
Research progress of magnetic resonance imagingon auditory hallucinations in schizophrenia
作者:
姜金波1; 吴 迪2; 刘文明2; 闵 妍2; 付宇斐3; 崔津津4; 崔龙彪1; 4
(1.空军军医大学临床心理学教研室,陕西 西安 710032; 2.空军军医大学西京医院心身科,陕西 西安 710032; 3.空军军医大学西京医院放射科,陕西 西安 710032; 4.解放军总医院第二医学中心放射科,北京 100853)
Author(s):
JIANG Jinbo; WU Di; LIU Wenming; MIN Yan; FU Yufei; CUI Jinjin; CUI Longbiao
(Department of Clinical Psychology,Air Force Medical University,Xi’an 710032,China)
关键词:
精神分裂症;  幻听;  神经影像学;  脑;  磁共振成像;  神经机制
Keywords:
Schizophrenia;  Auditory hallucinations;  Neuroimaging;  Brain;  Magnetic resonance imaging;  Neural mechanism
分类号:
R 749.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.04.033
文献标志码:
A
摘要:
精神分裂症是严重危害人类健康的严重性精神障碍,临床异质性极大,其防治一直是全球性医学难题。精神分裂症的临床症状复杂多样,因此基于阳性症状对精神分裂症进行亚分型具有十分重要的临床意义。幻听是精神分裂症的主要症状之一,高达60%～90%的患者伴有幻听症状,这也是精神分裂症诊断标准中的一项重要内容,因此幻听目前已被认为是精神分裂症的核心临床症状,阐明这一症状的神经机制对于进一步理解其疾病本质具有十分重要的科学意义和临床价值。现通过系统回顾精神分裂症幻听的磁共振成像(MRI)研究相关文献,探讨精神分裂症幻听研究现状及神经机制。
Abstract:
Schizophrenia is a serious mental disorder that seriously endangers human health,with great clinical heterogeneity,so its prevention and treatment are global challenges in medicine.The clinical symptoms of schizophrenia are complex and diverse,so it is of great significance to subtype schizophrenia based on positive symptoms.Auditory hallucination is one of the main symptoms of schizophrenia,with up to 60% to 90% of patients suffening from auditory hallucination symptoms,which is also an important part of the diagnostic criteria of schizophrenia.Therefore,auditory hallucinations have been considered as the core clinical symptoms of schizophrenia.Elucidation of its neural mechanism and deep understanding of this serious mental disorder have important scientific and clinical significance.This paper reviews the MRI research literature on schizophrenia auditory hallucinations in a systematic way,discussies the current status and neural mechanism of auditory hallucination in schizophrenia.

参考文献/References:

[1] Voineskos AN,Foussias G,Lerch J,et al.Neuroimaging evidence for the deficit subtype of schizophrenia [J].JAMA Psychiatry,2013,70(5):472-480.
[2] Bucci S,Birchwood M,Twist L,et al.Predicting compliance with command hallucinations:Anger,impulsivity and appraisals of voices’ power and intent [J].Schizophrenia Research,2013,147(1):163-168.
[3] Zhuo C,Cheng L,Li G,et al.COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions [J].Brain Imaging Behav,2020,14(5):1373-1381.
[4] Benetti S,Pettersson-Yeo W,Allen P,et al.Auditory verbal hallucinations and brain dysconnectivity in the perisylvian language network:A multimodal investigation [J].Schizophr Bull,2015,41(1):192-200.
[5] Stephane M,Burton P,Meriwether D,et al.“Other” tags for “Self”-generated speech in patients with auditory verbal hallucinations,an fMRI study [J].Schizophr Res,2018,202:410-411.
[6] Scheinost D,Tokoglu F,Hampson M,et al.Data-driven analysis of functional connectivity reveals a potential auditory verbal hallucination network [J].Schizophr Bull,2019,45(2):415-424.
[7] Liu S,Wang H,Song M,et al.Linked 4-way multimodal brain differences in schizophrenia in a large chinese han population [J].Schizophr Bull,2019,45(2):436-449.
[8] Stephane M,Burton P,Meriwether D,et al.Spatial externalization of inner verbal thoughts in auditory verbal hallucinations,an fMRI study [J].Schizophr Res,2018,202:417-419.
[9] Jing R,Huang J,Jiang D,et al.Distinct pattern of cerebral blood flow alterations specific to schizophrenics experiencing auditory verbal hallucinations with and without insight:A pilot study [J].Oncotarget,2018,9(6):6763-6770.
[10] Kose G,Jessen K,Ebdrup BH,et al.Associations between cortical thickness and auditory verbal hallucinations in patients with schizophrenia:A systematic review [J].Psychiatry Res Neuroimaging,2018(282):31-39.
[11] Cui Y,Liu B,Song M,et al.Auditory verbal hallucinations are related to cortical thinning in the left middle temporal gyrus of patients with schizophrenia [J].Psychol Med,2018,48(1):115-122.
[12] Chen X,Liang S,Pu W,et al.Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia [J].BMC Psychiatry,2015,15:152.
[13] Huang P,Xi Y,Lu ZL,et al.Decreased bilateral thalamic gray matter volume in first-episode schizophrenia with prominent hallucinatory symptoms:A volumetric MRI study [J].Sci Rep,2015,5:14505.
[14] Cierpka M,Wolf ND,Kubera KM,et al.Cerebellar contributions to persistent auditory verbal hallucinations in patients with schizophrenia [J].Cerebellum,2017,16(5-6):964-972.
[15] Alonso-Solis A,Vives-Gilabert Y,Portella MJ,et al.Altered amplitude of low frequency fluctuations in schizophrenia patients with persistent auditory verbal hallucinations [J].Schizophr Res,2017,189:97-103.
[16] Cui LB,Liu K,Li C,et al.Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinations [J].Schizophr Res,2016,173(1):13-22.
[17] Han SD,Nestor PG,Hale-Spencer M,et al.Functional neuroimaging of word priming in males with chronic schizophrenia [J].Neuroimage,2007,35(1):273-282..
[18] Lawrie SM,Buechel C,Whalley HC,et al.Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations [J].Biological Psychiatry,2002,51(12):1008-1011.
[19] Lavigne KM,Woodward TS.Hallucination- and speech-specific hypercoupling in frontotemporal auditory and language networks in schizophrenia using combined task-based fMRI data:An fBIRN study [J].Hum Brain Mapp,2018,39(4):1582-1595.
[20] Huang P,Cui LB,Li X,et al.Identifying first-episode drug naive patients with schizophrenia with or without auditory verbal hallucinations using whole-brain functional connectivity:A pattern analysis study[J].Neuroimage Clin,2018,19:351-359.
[21] Liu L,Cui LB,Xi YB,et al.Association between connectivity of hippocampal sub-regions and auditory verbal hallucinations in schizophrenia[J].Front Neurosci,2019,3(13):424.
[22] Hashimoto RI,Itahashi T,Okada R,et al.Linked functional network abnormalities during intrinsic and extrinsic activity in schizophrenia as revealed by a data-fusion approach [J].Neuroimage Clin,2018,17:69-79.
[23] Wigand M,Kubicki M,Hohenberg CC,et al.Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia [J].World Journal of Biological Psychiatry,2015,16(1):31-44.
[24] Weijer AD,Mandl RCW,Diederen KMJ,et al.Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations [J].Schizophrenia Research,2011,130(1):68-77.
[25] Kn?hel C,Oertel-Kn?hel V,Sch?meyer R,et al.Interhemispheric hypoconnectivity in schizophrenia:Fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives [J].Neuroimage,2012,59(2):926-934.
[26] Xi YB,Guo F,Li H,et al.The structural connectivity pathology of first-episode schizophrenia based on the cardinal symptom of auditory verbal hallucinations[J].Psychiatry Res Neuroimaging,2016,30(257):25-30.
[27] Whitford TJ,Lee SW,Oh Jungsu S,et al.Localized abnormalities in the cingulum bundle in patients with schizophrenia:A Diffusion Tensor tractography study [J].NeuroImage Clinical,2014,5:93-99.
[28] Anna RJ,Viola OK,Federico DM,et al.Anatomical brain connectivity and positive symptoms of schizophrenia:A diffusion tensor imaging study [J].Psychiatry Research:Neuroimaging,2009,174(1):9-16.
[29] Shergill SS,Kanaan RA,Chitnis XA,et al.A diffusion tensor imaging study of fasciculi in schizophrenia [J].Am J Psychiatry,2007,164(3):467-473.
[30] Lee KU,Yoshida T,Kubicki Mk,et al.Increased diffusivity in superior temporal gyrus in patients with schizophrenia:A Diffusion Tensor Imaging study [J].Schizophrenia Research,2009,108(1):33-40.
[31] 陈叶林,陈亚明.精神分裂症透明隔间腔的磁共振分析[J].陕西医学杂志,2017,46(9):1242-1243,1257.

相似文献/References:

[1]刘飞虎,吴强驹,崔小花,等.精神分裂症患者与饮用水锂元素水平关系及相关基因调查研究*[J].陕西医学杂志,2019,(4):535.
　LIU Feihu,WU Qiangju,CUI Xiaohua,et al.Relationship between schizophrenia patients and lithium levels in drinking water and related genes[J].,2019,(4):535.
[2]李 涛,李界兴△,尚同军,等.奥氮平片与利培酮片治疗男性精神分裂症疗效、安全性及对患者生活质量影响对比研究[J].陕西医学杂志,2019,(5):657.
　LI Tao,LI Jiexing,SHANG Tongjun,et al.A comparative study on the efficacy, safety and impact of olanzapine tablets and risperidone tablets on male patients with schizophrenia[J].,2019,(4):657.
[3]阎得胜,闫可域,祁 婧,等.老年患者341例抗精神病用药分析*[J].陕西医学杂志,2020,49(3):337.
　YAN Desheng,YAN Keyu,QI Jing,et al.Prescription analysis of 341 elderly patients with antipsychotics[J].,2020,49(4):337.
[4]常晓娟,赵千渃,赵 璇,等.阿立哌唑联合舍曲林治疗精神分裂症伴抑郁症临床疗效观察*[J].陕西医学杂志,2020,49(12):1669.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.035]
　CHANG Xiaojuan,ZHAO Qianruo,ZHAO Xuan,et al.Clinical efficacy of aripiprazole combined with sertraline in treatment of schizophrenia with depression[J].,2020,49(4):1669.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.035]
[5]万育辰,王化宁,吕辉珍,等.氨磺必利对精神分裂症伴抑郁患者正负性情绪、应对方式的影响[J].陕西医学杂志,2021,50(9):1131.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.022]
　WAN Yuchen,WANG Huaning,LYU Huizhen,et al.Effect of amsulapride on positive and negative emotions and coping styles in schizophrenic patients with depression[J].,2021,50(4):1131.[doi:DOI:10.3969/j.issn.1000-7377.2021.09.022]

备注/Memo

备注/Memo:
基金项目:中国博士后科学基金资助项目(2019TQ0130); 空军军医大学人才扶持“凌云工程”雏鹰计划(2019CYJH)
更新日期/Last Update: 2021-04-06