[1]安 敏,高振军.美沙拉秦长期治疗对溃疡性结肠炎患者结肠黏膜癌相关基因表达的影响[J].陕西医学杂志,2021,50(4):485-488.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.027]
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美沙拉秦长期治疗对溃疡性结肠炎患者结肠黏膜癌相关基因表达的影响
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年4期
页码:
485-488
栏目:
药物与临床
出版日期:
2021-04-05

文章信息/Info

作者:
安 敏高振军
(复旦大学附属中山医院青浦分院消化科,上海 210007)
关键词:
溃疡性结肠炎 结直肠癌 美沙拉秦 基因 黏膜癌 5-氨基水氧酸
分类号:
R 574.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.04.027
文献标志码:
A
摘要:
目的:探讨美沙拉秦长期治疗对溃疡性结肠炎(UC)患者结肠黏膜癌相关基因表达的影响。方法: 收集接受长期美沙拉秦治疗的61例UC患者作为研究对象,观察治疗前后癌症和炎症相关基因,采用多元回归分析观察相关基因变化率与药物应用时间的相关性。结果: 治疗后患者细胞增殖核抗原(Ki-67)、癌胚抗原相关细胞黏附分子 -1(CEACAM-1)、人Bcl-2样蛋白1(BCL2L1)、p53、CXC趋化因子配体10(CXCL10)、过氧化物酶体增殖物激活受体-γ(PPAR-γ)、核因子-κB(NF-κB)mRNA相对表达水平均较治疗前显著降低,差异均有统计学意义(均P<0.05); 治疗后患者细胞分裂周期因子25A(CDC25A)、钙黏蛋白相关蛋白(CTNNB1)、环氧化酶-2(COX-2)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平均低于治疗前,但差异无统计学意义(均P>0.05)。治疗后患者Mayo AI评分和Nancy组织病理评分均较治疗前显著降低(均P<0.05)。多元回归模型预测药物应用时间与Ki-67、NF-κB、PPAR-γ、COX-2、IL-8、CXCL10、CDC25A基因变化率显著相关(P<0.05),内镜检查评分降低与Ki-67、NF-κB和CXCL10基因变化率显著相关(P<0.05),Mayo AI评分降低与COX-2、IL-8、CDC25A基因变化率显著相关(P<0.05),Nancy组织病理评分降低与COX-2、IL-8基因变化率显著相关(P<0.05)。结论: 美沙拉秦长期治疗可调控与癌变相关的多个基因,为UC患者长期使用5-氨基水氧酸(5-ASA)作为结直肠癌化学预防提供了依据。

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更新日期/Last Update: 2021-04-06