[1]杨 帆,高 盼.血小板参数、D-二聚体在妊娠高血压综合征早期肾损伤患者中的表达及临床意义[J].陕西医学杂志,2021,50(4):413-416.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.007]
　YANG Fan,GAO Pan.Expression and clinical significance of platelet parameters and D-dimer in patients with early-stage renal injury in pregnancy-induced hypertension syndrome[J].,2021,50(4):413-416.[doi:DOI:10.3969/j.issn.1000-7377.2021.04.007]
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血小板参数、D-二聚体在妊娠高血压综合征早期肾损伤患者中的表达及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年4期
页码:
413-416
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Expression and clinical significance of platelet parameters and D-dimer in patients with early-stage renal injury in pregnancy-induced hypertension syndrome
作者:
杨 帆1; 高 盼2
(1.汉中市中心医院妇产科,陕西 汉中723000; 2.陕西中医药大学第二附属医院妇科,陕西 咸阳712000)
Author(s):
YANG Fan; GAO Pan
(Department of Obstetrics and Gynecology,Hanzhong Central Hospital,Hanzhong 723000,China)
关键词:
妊娠高血压综合征;  血小板;  D-二聚体;  肾功能;  病情;  预测
Keywords:
Pregnancy-induced hypertension syndrome;  Platelets;  D-dimer;  Renal function;  Pathogenetic condition;  Prediction
分类号:
R 714.25
DOI:
DOI:10.3969/j.issn.1000-7377.2021.04.007
文献标志码:
A
摘要:
目的:探究血小板参数、D-二聚体(D-D)在妊娠高血压综合征(PIH)早期肾损伤患者体内的表达及临床意义。方法:以92例PIH患者(观察组妊娠高血压34例、轻度子痫前期33例、重度子痫前期25例)和45例正常产检孕妇(对照组)为对象。依据内生肌酐清除率(Ccr)将观察组分为肾功能正常(48例)和异常(44例)组。检测分析不同受试者血小板功能指标血小板计数(PLT)、血小板平均容积(MPV)和血清D-二聚体(D-D)、尿素(Urea)、尿微量白蛋白(UALB)、脂质运载蛋白(NGAL)水平,Pearson法分析其相关性; 受治者工作特征(ROC)曲线分析预测价值。结果:肾功能指标Urea、UALB、NGAL和D-D水平观察组高于对照组,重度子痫前期高于轻度子痫前期和妊高压者,肾功能异常者高于正常者(均P<0.01),血小板参数PLT观察组少于对照组,重度子痫前期少于轻度子痫前期和妊高压者,肾功能异常者少于正常者(P<0.01),MPV观察组大于对照组,重度子痫前期大于轻度子痫前期和妊高压者,肾功能异常者大于正常者(P<0.01)。ROC曲线分析显示,PLT、MPV和 D-D水平均对PIH患者早期肾功能损伤具有一定预测价值(均P<0.05)。观察组PLT与Urea、UALB、NGAL水平显著负相关,MPV和D-D水平之间显著正相关(P<0.05)。结论:PLT随PIH病情加重减少,MPV和D-D随病情加重而增加,与肾功能指标显著相关,可作为评估PIH患者早期肾损伤的指标。
Abstract:
Objective:To explore the expression and clinical significance of platelet parameters and D-dimer(D-D)in patients with early-stage renal injury in pregnancy-induced hypertension syndrome(PIH).Methods:92 cases of PIH cases(observation group,34 cases of pregnancy-induced hypertension,33 cases of mild preeclampsia,25 cases of severe preeclampsia)and 45 normal pregnant women(control group)were selected as the subjects.According to the endogenous creatinine clearance rate(Ccr),the observation group was divided into normal renal function(48 cases)and abnormality(44 cases).Different subjects' platelet count(PLT),mean platelet volume(MPV)and serum D-dimer(D-D),urea,urine microalbumin(UALB),lipocalin(NGAL)levels were measured.The correlation of serum indicators was analyzed by Pearson's method.The ROC curve was used to analyze the predict value.Results:The levels of urea,UALB,NGAL and D-D were higher in the observation group than those in the control group,and the levels of urea,UALB,NGAL and D-D of severe preeclampsia patients were higher than those of mild preeclampsia and pregnancy-induced hypertension patients,and the levels of urea,UALB,NGAL and D-D of abnormal renal function patients were higher than those of normal renal function patients(all P<0.01).The PLT of the observation group was less than that in the control group,and the PLT of severe preeclampsia patients was less than that of mild preeclampsia and pregnancy-induced hypertension patients,and the PLT of renal dysfunction patients was less than that of normal renal function patients(P<0.01).The MPV of the observation group was larger than that of the control group,and the MPV of severe preeclampsia patients was greater than that of mild preeclampsia and pregnancy-induced hypertension patients,and the MPV of renal dysfunction patients was larger than that of normal renal function patients(P<0.01).The levels of PLT in the observation group was negatively correlated with urea,UALB and NGAL,and MPV and D-D levels were positively correlated with urea,UALB and NGAL(all P<0.05).ROC curve analysis showed that PLT,MPV and D-D levels had certain predictive value for early-stage renal function injury in PIH patients(all P<0.05).Conclusion:PLT decreases with the aggravation of PIH,MPV and D-D increase with the aggravation of PIH,which are significantly correlated with renal function indexes,and can be used as indexes to evaluate early renal injury in patients with PIH.

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备注/Memo

备注/Memo:
基金项目:陕西省科技厅科技计划项目(2016C52035)
更新日期/Last Update: 2021-04-06