[1]崔 佳,刘敏丽.乙酰左旋肉碱对脊髓损伤后线粒体的保护作用研究进展[J].陕西医学杂志,2021,50(3):374-376.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.031]
　CUI Jia,LIU Minli.Protective effect of acetyl L-carnitine on mitochondria after spinal cord injury[J].,2021,50(3):374-376.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.031]
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乙酰左旋肉碱对脊髓损伤后线粒体的保护作用研究进展
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年3期
页码:
374-376
栏目:
综述
出版日期:
2021-03-01

文章信息/Info

Title:
Protective effect of acetyl L-carnitine on mitochondria after spinal cord injury
作者:
崔 佳; 刘敏丽
(延安大学医学院神经生物学实验室,陕西 延安 716000)
Author(s):
CUI Jia; LIU Minli
(Neurobiology Laboratory,Medical College,Yan'an University,Yan'an 716000,China)
关键词:
脊髓损伤;  乙酰左旋肉碱;  线粒体;  神经保护;  氧化应激;  细胞凋亡
Keywords:
Spinal cord injury;  Acetyl L-carnitine;  Mitochondria;  Neuroprotection;  Oxidative stress;  Apoptosis
分类号:
R 651.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.03.031
文献标志码:
A
摘要:
脊髓损伤是中枢神经系统的一种严重创伤,目前认为线粒体氧化损伤和诱导细胞凋亡是急性脊髓损伤的重要致病机制。乙酰左旋肉碱(ALC)是生物体内含量最丰富的左旋肉碱衍生物,其抗炎症、抗氧化、抗凋亡及促进脂肪代谢等生物学作用可能对脊髓损伤的治疗有重要意义。现通过文献回顾,就乙酰左旋肉碱对脊髓损伤后线粒体的保护机制进行综述。
Abstract:
Spinal cord injury is a serious injury to the central nervous system.At present,it is believed that mitochondrial oxidative damage and apoptosis induction are the important pathogenic mechanisms of acute spinal cord injury.Acetyl L-carnitine is the most abundant L-carnitine derivative in vivo.Its anti-inflammatory,anti-oxidant,anti-apoptotic and lipid metabolism promoting biological effects may be of great significance for the treatment of spinal cord injury.In this paper,the protective mechanism of acetyl L-carnitine on mitochondria after spinal cord injury is reviewed through literature review.

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备注/Memo

备注/Memo:
基金项目:国家级大学生创新创业训练计划项目(201910719051); 陕西省卫生健康委员会科研项目(2018D079)
更新日期/Last Update: 2021-03-04