[1]王 洁,张云清,赵 斌,等.K-ras诱导细胞衰老与胃癌及癌前病变关系研究[J].陕西医学杂志,2021,50(3):370-373.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.030]
　WANG Jie,ZHANG Yunqing,ZHAO Bin,et al.Relationship between K-ras-induced cellular senescence and gastric cancer and precancerous lesions[J].,2021,50(3):370-373.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.030]
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K-ras诱导细胞衰老与胃癌及癌前病变关系研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年3期
页码:
370-373
栏目:
临床病理
出版日期:
2021-03-01

文章信息/Info

Title:
Relationship between K-ras-induced cellular senescence and gastric cancer and precancerous lesions
作者:
王 洁1; 张云清1; 赵 斌1; 尹香利1; 2
(1.延安大学附属医院,陕西 延安 716000; 2.渭南市中心医院,陕西 渭南 714000)
Author(s):
WANG Jie; ZHANG Yunqing; ZHAO Bin; YIN Xiangli
(Affiliated Hospital of Yan'an University,Yan'an 716000,China)
关键词:
胃癌;  癌前病变;  K-ras;  细胞衰老;  免疫组化
Keywords:
Gastric carcinoma;  Precancerous lesion;  K-ras;  Cell senescence;  Immunohistochemistry
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.03.030
文献标志码:
A
摘要:
目的:对比胃癌与癌前病变组织中K-ras蛋白表达的差异,分析K-ras诱导的细胞衰老与胃癌及癌前病变的关系。方法:收集138例管状腺癌患者的病理样本,进行HE染色和免疫组化染色,检测胃癌及癌旁石蜡包埋组织中K-ras、SA-β-Gal、P53、P16INK4a蛋白的表达。结果:K-ras蛋白在胃癌组织中阳性表达率显著高于癌旁组织(95.7%与3.6%)(P<0.05)。胃癌组织及癌旁组织中K-ras阳性组SA-β-Gal、P53、P16INK4a表达率均高于K-ras阴性组(均P<0.05)。结论:K-ras诱导的细胞衰老与胃癌的发生、发展密切相关。
Abstract:
Objective:To compare the expression of K-ras protein in gastric cancer and precancerous lesions,and to analyze the relationship between K-ras-induced cellular senescence and gastric cancer and precancerous lesions.Methods:138 gastric tubular adenocarcinoma specimens were collected,and HE staining and immunohistochemical staining were performed.The expression of K-ras,SA-β-Gal,P53 and P16INK4a in gastric cancer and adjacent tissues were detected.Results:The positive expression rate of K-ras protein in gastric cancer tissues was significantly higher than that in adjacent tissues(95.7% vs.3.6%)(P<0.05).The positive rates of SA-β-Gal,P53 and P16INK4a expression of K-ras positive group in gastric cancer tissues and adjacent tissues were higher than those in K-ras negative group(all P<0.05).Conclusion:K-ras-induced cellular senescence is closely related to the occurrence and development of gastric cancer.

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备注/Memo

备注/Memo:
基金项目:陕西省延安市科技攻关计划项目(2017KS-11-02)
更新日期/Last Update: 2021-03-04