[1]焦建虎,刘新琼,侯 瑜,等.2型糖尿病患者继发泌汗功能障碍影响因素及其与早期相胰岛分泌功能相关性分析[J].陕西医学杂志,2021,50(3):330-333.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.019]
　JIAO Jianhu,LIU Xinqiong,HOU Yu,et al.Influencing factors of secondary sudomotor dysfunction in T2DM and its correlation with early phase pancreatic islet secretion function[J].,2021,50(3):330-333.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.019]
点击复制

2型糖尿病患者继发泌汗功能障碍影响因素及其与早期相胰岛分泌功能相关性分析
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年3期
页码:
330-333
栏目:
临床研究
出版日期:
2021-03-01

文章信息/Info

Title:
Influencing factors of secondary sudomotor dysfunction in T2DM and its correlation with early phase pancreatic islet secretion function
作者:
焦建虎1; 刘新琼1; 侯 瑜1; 雷 婷1; 向惠敏1;  刘 洋2
(1.铜川市人民医院内分泌科,陕西 铜川 727100; 2.铜川矿务局中心医院内分泌科,陕西 铜川 727000)
Author(s):
JIAO Jianhu; LIU Xinqiong; HOU Yu; LEI Ting; XIANG Huimin; LIU Yang
(Department of Endocrinology,Tongchuan People's Hospital,Tongchuan 727100,China)
关键词:
2型糖尿病;  糖尿病周围神经病变;  泌汗功能;  影响因素;  胰岛功能;  相关性分析
Keywords:
T2DM;  Diabetic peripheral neuropathy;  Sudomotor function;  Influencing factor;  Pancreatic islet function;  Correlation analysis
分类号:
R 587.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.03.019
文献标志码:
A
摘要:
目的:探讨2型糖尿病(T2DM)患者继发泌汗功能障碍影响因素及其与早期相胰岛分泌功能相关性。方法:回顾性分析770例T2DM患者临床资料,根据是否继发泌汗功能障碍分为泌汗功能正常组(524例)和泌汗功能障碍组(246例)。比较两组患者一般临床资料和实验室指标[尿酸(UA)、糖化血红蛋白(HbA1c)、泌汗功能障碍组糖负荷30 min净增C肽与葡萄糖(ΔC-P30/ΔG30)、净增胰岛素与葡萄糖比值(ΔI30/ΔG30)、120 min血糖曲线下面积(AUC)校正后的C肽和胰岛素AUC(I-AUC/G-AUC与C-P-AUC/G-AUC)等]。T2DM继发泌汗功能障碍与早期相胰岛分泌功能相关性采用Spearman相关性分析。T2DM继发泌汗功能障碍的独立影响因素采用多元逐步线性回归法分析。结果:泌汗功能障碍组年龄和病程均高于泌汗功能正常组(均P<0.05)。泌汗功能障碍组ΔC-P30/ΔG30、ΔI30/ΔG30、I-AUC/G-AUC及C-P-AUC/G-AUC均低于泌汗功能正常组(均P<0.05)。Spearman相关性分析结果显示,ΔC-P30/ΔG30、ΔI30/ΔG30与HESC和FESC均呈正相关(均P<0.05)。多元逐步线性回归分析结果显示,ΔC-P30/ΔG30、病程、年龄、HbA1c及UA是T2DM继发泌汗功能障碍独立影响因素(均P<0.05)。结论:T2DM继发泌汗功能障碍与ΔC-P30/ΔG30、病程、年龄、HbA1c及UA独立相关,其中早期相胰岛分泌功能损伤越严重者继发泌汗功能障碍风险越高。
Abstract:
Objective:To investigate the influencing factors of secondary sudomotor dysfunction in T2DM and its correlation with early phase pancreatic islet secretion function.Methods:Clinical data of 770 patients with T2DM were retrospectively analyzed.According to whether secondary sudomotor dysfunction occurred,they were divided into normal sudomotor group(524 cases)and sudomotor dysfunction group(246 cases).The general clinical data and laboratory indexes were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between secondary sudomotor dysfunction and early phase pancreatic islet secretion function.Multiple stepwise linear regression analysis was used to analyze the independent influencing factors of secondary sudomotor dysfunction in T2DM.Results:The age and course of disease in sudomotor dysfunction group were higher than those in normal sudomotor group(all P<0.05).The levels of ΔC-P30/ΔG30,ΔI30/ΔG30,I-AUC/G-AUC,C-P-AUC/G-AUC in sudomotor dysfunction group were lower than those in normal sudomotor group(all P<0.05).Spearman correlation analysis showed that ΔC-P30/ΔG30 and ΔI30/ΔG30 were positively correlated with HESC and FESC(all P<0.05).Multiple stepwise linear regression analysis showed that ΔC-P30/ΔG30,course of disease,age,HbA1c and UA were independent influencing factors of secondary sudomotor dysfunction in T2DM(all P<0.05).Conclusion:The secondary sudomotor dysfunction in T2DM is independently related to ΔC-P30/ΔG30,course of disease,age,HbA1c and UA.The more severe the early phase of pancreatic islet secretion dysfunction,the higher the risk of secondary sudomotor dysfunction.

参考文献/References:

[1] 齐 婷,左 红,黎国红,等.不同剂量阿托伐他汀钙片联合阿司匹林肠溶片对糖尿病患者动脉粥样硬化斑块稳定性影响的对比分析[J].陕西医学杂志,2019,48(1):92-95.
[2] 胡方舟,杨雯月,谢小红,等.2型糖尿病患者合并周围神经病变的危险因素分析[J].中华全科医学,2018,16(5):781-784.
[3] Sztanek F,Balogh B,Molnár A,et al.Diabetic neuropathy and other diabetic complications at the Diabetic Neuropathy Center of the University of Debrecen[J].Orv Hetil,2020,161(30):1243-1251.
[4] Shivaprasad C,Amit G,Anish K,et al.Clinical correlates of sudomotor dysfunction in patients with type 2 diabetes and peripheral neuropathy[J].Diabetes Res Clin Pract,2018,139(5):188-194.
[5] Carbajal-Ramírez A,Hernández-Domínguez JA,Molina-Ayala MA,et al.Early identification of peripheral neuropathy based on sudomotor dysfunction in Mexican patients with type 2 diabetes[J].BMC Neurol,2019,19(1):109.
[6] Eleftheriadou I,Tentolouris A,Anastasiou IA,et al.Factors associated with sclerostin levels - a calcification inhibitor - in individuals with type 2 diabetes mellitus; is autonomic neuropathy the missing link?[J].J Diabetes Complications,2020,16(7):107677.
[7] Choi D,Kim BY,Jung CH,et al.Association between sleep quality and painless diabetic peripheral neuropathy assessed by current perception threshold in type 2 diabetes mellitus[J].Diabetes Metab J,2020,6(8):221-227.
[8] 刘 培,彭 俊,李书楠,等.益气养阴活血利水法联合康柏西普对非增殖期糖尿病视网膜病变患者视网膜电图的影响[J].陕西中医,2020,41(6):728-732.
[9] Casellini CM,Parson HK,Hodges K,et al.Bariatric surgery restores cardiac and sudomotor autonomic C-fiber dysfunction towards normal in obese subjects with type 2 diabetes[J].PLoS One,2016,11(5):e0154211.
[10] Cabré JJ,Mur T,Costa B,et al.Feasibility and effectiveness of electrochemical dermal conductance measurement for the screening of diabetic neuropathy in primary care.DECODING study(dermal electrochemical conductance in diabetic neuropathy).Rationale and design[J].Medicine(Baltimore),2018,97(20):e10750.
[11] Binns-Hall O,Selvarajah D,Sanger D,et al.One-stop microvascular screening service:An effective model for the early detection of diabetic peripheral neuropathy and the high-risk foot[J].Diabet Med,2018,35(7):887-894.
[12] Campos FC,Viana P,Castro I,et al.Non-invasive evaluation of sudomotor function in patients with myasthenia gravis[J].Neurophysiol Clin,2019,49(1):81-86.
[13] Chahal S,Vohra K,Syngle A.Association of sudomotor function with peripheral artery disease in type 2 diabetes[J].Neurol Sci,2017,38(1):151-156.
[14] Maser RE,Lenhard JM,Pohlig RT,et al.Osteopontin and clusterin levels in type 2 diabetes mellitus:Differential association with peripheral autonomic nerve function[J].Neurol Sci,2017,38(9):1645-1650.
[15] Sohn EH,Song KS,Lee JY,et al.Comparison of somatic and sudomotor nerve fibers in type 2 diabetes mellitus[J].J Clin Neurol,2017,13(4):366-370.
[16] Lim LL,Fu AWC,Lau ESH,et al.Sudomotor dysfunction independently predicts incident cardiovascular-renal events and all-cause death in type 2 diabetes:Joint asia diabetes evaluation register[J].Nephrol Dial Transplant,2019,34(8):1320-1328.
[17] Fang P,Dong J,Zeng F,et al.Analysis of the association between glucose profiles and β-cell function for diabetic cardiovascular autonomic neuropathy in China[J].J Diabetes Investig,2017,8(3):354-362.

相似文献/References:

[1]李艳艳,贾 伟△.24h动态心电图在2型糖尿病合并冠心病患者心律诊断中的价值分析[J].陕西医学杂志,2019,(1):61.
[2]郭向东,马 波△.2型糖尿病患者血清胰岛素水平与骨代谢关联研究*[J].陕西医学杂志,2019,(1):77.
　GUO Xiangdong,MA Bo..Association between serum insulin level and bone metabolismin patients with type 2 diabetes mellitus[J].,2019,(3):77.
[3]刘毅龙,陈鹏宇,雷 江,等.SGLT2抑制剂在2型糖尿病合并心血管疾病治疗中的应用研究进展[J].陕西医学杂志,2019,(3):407.
[4]姚爱红.利拉鲁肽治疗2型糖尿病效果及对患者血脂、颈动脉内膜中层厚度的影响[J].陕西医学杂志,2019,(4):518.
　YAO Aihong..Effect of liraglutide on type 2 diabetes mellitus in patients with blood lipids and carotid intimamedia thickness[J].,2019,(3):518.
[5]李忆琴,吴礼凤,余晓君,等.中年2型糖尿病患者病程和HbA1c水平与认知功能相关性研究*[J].陕西医学杂志,2019,(6):722.
[6]徐 琳,贾睿博△,宋民喜,等.颗粒蛋白前体与糖尿病肾病关系探讨*[J].陕西医学杂志,2019,(8):1024.
[7]王荣锋,郁 昊,蒋新建.老年糖尿病患者血清25羟维生素D水平与骨质疏松相关性研究[J].陕西医学杂志,2019,(8):1032.
　WANG Rongfeng,YU Hao,JIANG Xinjian..The relationship between serum 25 hydroxy vitamin D and osteoporosis in elderly diabetic patients[J].,2019,(3):1032.
[8]王 荣,贾爱华,刘新艳 ,等.IGF1及其相关性因素对2型糖尿病并发骨质疏松的影响研究[J].陕西医学杂志,2019,(9):1163.
　WANG Rong,JIA Aihua,LIU Xinyan,et al.The effect of IGF1 and its related factors in type 2 diabetes complicated with osteoporosis[J].,2019,(3):1163.
[9]贾睿博,徐 琳△.2型糖尿病患者下肢血管病变相关危险因素调查研究[J].陕西医学杂志,2019,(11):1567.
[10]郭建强,赵俊宏,张分队,等.2型糖尿病视网膜病变患者血清HbA1c、CysC检测及临床意义*[J].陕西医学杂志,2020,49(5):619.
　GUO Jianqiang,ZHAO Junhong,ZHANG Fendui,et al.Changes of serum HbA1c and CysC in patients with type 2 diabetic retinopathy and their clinical significance[J].,2020,49(3):619.
[11]石 敏,邹 健,李乔岳,等.2型糖尿病患者糖化白蛋白和糖化血红蛋白比值与周围神经病变相关性研究*[J].陕西医学杂志,2020,49(12):1557.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.005]
　SHI Min,ZOU Jian,LI Qiaoyue,et al.Association between GA/HbA1c ratio and diabetic peripheral neuropathy in patients with type 2 diabetes[J].,2020,49(3):1557.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.005]

更新日期/Last Update: 2021-03-04