[1]谢倩倩,高秀秋,张 超.慢性牙周炎合并2型糖尿病患者龈沟液内脂素水平检测及临床意义[J].陕西医学杂志,2021,50(2):233-235,240.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.027]
　XIE Qianqian,GAO Xiuqiu,ZHANG Chao.Expression level and clinical significance of visfatin in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus[J].,2021,50(2):233-235,240.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.027]
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慢性牙周炎合并2型糖尿病患者龈沟液内脂素水平检测及临床意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
233-235,240
栏目:
临床检验
出版日期:
2021-02-05

文章信息/Info

Title:
Expression level and clinical significance of visfatin in gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus
作者:
谢倩倩; 高秀秋; 张 超
(锦州医科大学附属第二医院,辽宁 锦州121000)
Author(s):
XIE Qianqian; GAO Xiuqiu; ZHANG Chao
(The Second Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
关键词:
内脂素;  慢性牙周炎;  2型糖尿病;  探诊深度;  附着丧失;  出血指数;  菌斑指数
Keywords:
Visfatin;  Chronic periodontitis;  Type 2 diabetes mellitus;  Probing depth;  Attachment loss;  Bleeding index;  Plaque index
分类号:
R 781.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.027
文献标志码:
A
摘要:
目的:探讨2型糖尿病合并牙周炎患者龈沟液中内脂素(Visfatin)表达水平及临床意义。方法:随机选取健康体检者(A组)、慢性牙周炎患者(B组)和2型糖尿病合并牙周炎患者组(C组),每组30例,记录各组牙周临床指标:探诊深度(PD)、附着丧失(AL)、出血指数(BI)及菌斑指数(PLI)。收集各组龈沟液并运用ELISA法检测各组龈沟液中内脂素水平,高效液相层析法检测各组受检者糖化血红蛋白(HbA1c)水平。结果:C组患者龈沟液中内脂素表达水平明显高于A、B组(均P<0.05); 全部受试者中,内脂素表达水平与各牙周临床指标及HbA1c均呈正相关性(均P<0.001)。结论:龈沟液中内脂素可能作为一种炎症标志物参与2型糖尿病合并牙周炎的发病过程。
Abstract:
Objective:To explore the expression level and clinical significance of visfatin in the gingival crevicular fluid(GCF)of patients with type 2 diabetes and chronic periodontitis.Methods:30 healthy subjects(group A),30 chronic periodontitis patients(group B),30 chronironic periodontitis patients with type 2 diabetes mellitus(group C)were included.Probing depth(PD),attachment loss(AL),bleeding index(BI)and plaque index(PLI)were examined.The gingival crevicular fluid of each group was collected,and the level of visfatin in GCF of each group was detected by ELISA,and the level of glycosylated hemoglobin(HbA1c)in each group was detected by high performance liquid chromatography.Results:The expression level of visfatin in GCF of group C was significantly higher than that in groups A and B(all P<0.05).In all subjects,the expression level of visfatin was positively correlated with various periodontal clinical indicators and HbA1c(all P<0.001).Conclusion:Visfatin may be considered an inflammatory marker for chronic periodontitis patients with type 2 diabetes mellitus.

参考文献/References:

[1] Casanova L,Hughes FJ,Preshaw PM.Diabetes and periodontal disease:A two-way relationship[J].Br Dent J,2014,217(8):433-437.
[2] Costa FO,Miranda C,Luís O,et al.Progression of periodontitis and tooth loss associated with glycemic control in individuals undergoing periodontal maintenance therapy:A 5-year follow-up study[J].Journal of Periodontology,2013,84(5):595-605.
[3] Loe H.Periodontald disease.The sixth complication and diabetes mellitus[J].Diabetes Care,1993,16(1):329-334.
[4] Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin:A protein secreted by visceral fat that mimics the effects of insulin[J].Science(New York,NY),2005,307(5708):426-430.
[5] Pradeep AR,Raghavendra NM,Ramchandra MV,et al.Gingival crevicular fluid and serum visfatin concentration:Their relationship in periodontal health and disease[J].Journal of Periodontology,2011,82(9):1314-1319.
[6] 张 新,刘艳丽.糖尿病合并牙周病牙周基础治疗对龈沟液中MMP-3的影响[J].陕西医学杂志,2016,45(7):796-798.
[7] 武 玮,郝树立,周玉森,等.牙周基础治疗对2型糖尿病伴慢性牙周炎患者血清生化指标及炎性细胞因子的影响[J].中华全科医学,2020,18(2):249-251,281.
[8] 王 颖.益气降糖饮联合胰岛素对妊娠期糖尿病孕妇血糖、内脂素水平及妊娠结局的影响[J].陕西中医,2018,(10):1342-1344,1458.
[9] Haider K,Dominik G,Schindler G,et al.Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding[J].Journal of Clinical Endocrinology and Meta Bolism,2006,91(4):1578-1581.
[10] Abel LB,Berta CJ,Merce FB,et al.Serum visfatin increases with progressive beta-cell deterioration[J].Diabetes,2006,55(10):2871-2875.
[11] Ozcan E,Saygun NI,Ilikci R,et al.Increased visfatin expression is associated with nuclear factor-kappa B and phosphatidy linositol 3-kinase in periodontal inflam–mation[J].Clin Oral Investig,2017,21(4):1113-1121.
[12] 胥丹妮,林晓萍.脂肪因子对牙周炎症组织影响机制的研究[J].口腔医学,2017,24(10):134-138.
[13] 孔燕凌,徐月启,张乃晨,等.加味清胃汤治疗慢性牙周炎疗效及对患者牙周菌斑分布、炎症水平、PGE2水平的影响[J].陕西中医,2018,39(7):928-930.
[14] 刘海涛,牛文燕.慢性牙周炎患者基础治疗前后血清及龈沟液脂联素水平的变化及临床意义[J].陕西医学杂志,2018,47(2):225-227.
[15] Turer CC,Balli U,Guven B,et al.Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases[J].J Oral Sci,2016,58(4):491-499.
[16] Ozcan E,Isil SN,Serdar MA,et al.Non-surgical periodontal therapy reduces saliva adipokine and matrix metalloproteinase levels in periodontitis[J].J Periodontol,2016,87(8):934-943.
[17] Chen Z,Zhao GH,Zhang YK,et al.Research on the correlation of diabetes mellitus complicated with osteoporosis with lipid metabolism,adipokines and inflammatory factors and its regression analysis[J].Eur Rev Med Pharmacol Sci,2017,31:3900-3905.

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备注/Memo

备注/Memo:
基金项目:辽宁省中央引导地方科技发展专项(2018201002)
更新日期/Last Update: 2021-01-28