[1]强永春,李 佳.经尿道膀胱肿瘤电切术后吉西他滨膀胱热灌注化疗老年浅表性膀胱癌疗效与安全性研究[J].陕西医学杂志,2021,50(2):184-187.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.015]
　QIANG Yongchun,LI Jia.Efficacy and safety of hyperthermic bladder chemotherapy with gemcitabine after transurethral resection of bladder tumors in elderly with superficial bladder cancer[J].,2021,50(2):184-187.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.015]
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经尿道膀胱肿瘤电切术后吉西他滨膀胱热灌注化疗老年浅表性膀胱癌疗效与安全性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
184-187
栏目:
临床研究
出版日期:
2021-02-05

文章信息/Info

Title:
Efficacy and safety of hyperthermic bladder chemotherapy with gemcitabine after transurethral resection of bladder tumors in elderly with superficial bladder cancer
作者:
强永春; 李 佳
(延安大学咸阳医院泌尿外科,陕西 咸阳 712000)
Author(s):
QIANG Yongchun; LI Jia
(Department of Urology,Xianyang Hospital,Yan'an University,Xianyang 712000,China)
关键词:
老年人;  浅表性膀胱癌;  吉西他滨;  经尿道膀胱肿瘤电切术;  灌注化疗;  复发率
Keywords:
Aged;  Superficial bladder cancer;  Gemcitabine;  Transurethral resection of bladder tumor;  Perfusion chemotherapy;  Recurrence rate
分类号:
R 737.14
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.015
文献标志码:
A
摘要:
目的:探讨经尿道膀胱肿瘤电切术(TURBT)后吉西他滨膀胱热灌注化疗老年浅表性膀胱癌疗效及安全性。方法:按照随机摸球法将82例老年浅表性膀胱癌患者分为对照组(41例)与观察组(41例),在TURBT术后,分别给予吡柔比星、吉西他滨实施膀胱热灌注化疗; 比较两组治疗效果、不同时期肿瘤标志物与相关因子水平、不良反应发生率及术后复发率。结果:观察组治疗总有效率(97.56%)高于对照组(80.49%)(P<0.05); 观察组治疗后血管内皮生长因子(VEGF)、重组人Dickkopf相关蛋白1(DKK1)及可溶性血管细胞黏附分子1(sVCAM-1)、可溶性细胞间黏附因子1(sICAM-1)表达水平均低于对照组(均P<0.05); 观察组不良反应总发生率、术后1年复发率均低对照组(均P<0.05)。结论:吉西他滨膀胱灌注化疗TURBT术后老年浅表性膀胱癌患者的效果较好,能延缓患者病情发展进程,降低肿瘤细胞活力,且具有良好安全性,复发率较低。
Abstract:
Objective:To investigate the efficacy and safety of hyperthermic bladder chemotherapy with gemcitabine after transurethral resection of bladder tumors(TURBT)in the elderly with superficial bladder cancer.Methods:82 elderly patients with superficial bladder cancer were divided into the control group(41 cases)and the observation group(41 cases)according to the random ball-touch method.After TURBT,pirarubicin and gemcitabine were given respectively for bladder hyperthermic bladder chemotherapy.The treatment effects,tumor markers and related factors levels at different periods,the incidence of adverse reactions rate and postoperative recurrence rate were compared between the two groups.Results:The total effective rate in the observation group(97.56%)was higher than that in group A(80.49%)(P<0.05).After treatment,VEGF,DKK1,SVCAM-1 and sICAM-1 in the observation group were all lower than those in the control group(all P<0.05).The total incidence of adverse reactions and the recurrence rate 1 year after operation in the observation group were all lower than those in the control group(all P<0.05).Conclusion:Gemcitabine bladder infusion chemotherapy is effective in treating elderly patients with superficial bladder cancer after TURBT.It can delay the progression of the patient's condition,reduce the activity of tumor cells,and has good safety and low recurrence rate.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2018SF-143)
更新日期/Last Update: 2021-01-28