[1]邢 进,刘文忠.改良小切口切除术对甲状腺瘤患者围术期应激反应及免疫功能的影响研究[J].陕西医学杂志,2021,50(2):158-161.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.008]
　XING Jin,LIU Wenzhong.Influence of modified small incision resection on perioperative stress response and immune function in patients with thyroid tumor[J].,2021,50(2):158-161.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.008]
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改良小切口切除术对甲状腺瘤患者围术期应激反应及免疫功能的影响研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
158-161
栏目:
临床研究
出版日期:
2021-02-05

文章信息/Info

Title:
Influence of modified small incision resection on perioperative stress response and immune function in patients with thyroid tumor
作者:
邢 进; 刘文忠
(锦州医科大学附属第三医院耳鼻咽喉头颈外科,辽宁 锦州 121000)
Author(s):
XING Jin; LIU Wenzhong
(Department of Otorhinolaryngology Head and Neck Surgery,the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
关键词:
甲状腺瘤;  传统切除手术;  改良小切口切除术;  应激反应;  免疫功能
Keywords:
Thyroid tumor;  Traditional resection;  Modified small incision resection;  Stress response;  Immune function
分类号:
R 736.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.008
文献标志码:
A
摘要:
目的:探讨改良小切口切除术对甲状腺瘤患者围术期应激反应及免疫功能的影响。方法:选择 83例甲状腺瘤患者作为研究对象,按照随机数字表法,分为对照组与观察组,分别给予传统甲状腺切除术与改良小切口切除术,比较两组手术相关指标、围术期应激反应及免疫功能水平、不良反应发生情况。结果:①观察组手术时间、术中出血量、手术切口长度及术后住院时间均显著小于对照组(均P<0.05); ②两组T1、T2时皮质醇(COR)、去甲肾上腺素(NE)及总抗氧化能力(TAC)水平较本组T0时升高,两组间T1、T2时COR、NE及TAC水平比较均有统计学差异(均P<0.05); ③两组T1、T2时IL-6及TNF-α水平较本组T0时升高,两组间T1、T2时IL-6及TNF-α水平比较均有统计学差异(均P<0.05); ④经治疗后,观察组患者外周血CD3+、CD4+及CD4+/CD8+水平均显著高于治疗前及对照组患者治疗后(均P<0.05),但对照组患者治疗前后上述指标水平比较差异均无统计学意义(均P>0.05); ⑤观察组不良反应发生率为21.43%,显著低于对照组的41.46%(P<0.05)。结论:与传统开放手术相比,改良小切口切除术治疗甲状腺瘤疗效更加确切,对患者机体应激反应及免疫功能的影响更小,可在临床上进一步推广。
Abstract:
Objective:To investigate the effect of modified small incision resection on perioperative stress response and immune function in patients with thyroid tumor.Methods:A total of 83 patients with thyroid tumor were selected as study subjects.According to the random number table method,they were divided into control group(41 cases)and observation group(42 cases),and traditional thyroidectomy and modified small incision resection were performed respectively.The operation related indexes,perioperative stress reaction,immune function level and adverse reactions were compared between the two groups.Results:The operative time,intraoperative blood loss,operative incision length and postoperative hospital stay in the observation group were significantly lower than those in the control group(all P<0.05).The COR,NE,TAC,IL-6 and TNF-α levels at T1 and T2 in both groups were significantly higher than those at T0 in the same group(all P<0.05),and there was significant differences in above indicators at T1 and T2 between two groups.After treatment,the levels of CD3+,CD4+ and CD4+/CD8+ in peripheral blood of patients in the observation group were significantly higher than those before and after treatment in the control group(all P<0.05),but there were no statistically significant differences in the levels of the above indicators before and after treatment in the control group(all P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(21.43% vs.41.46%)(P<0.05).Conclusion:Compared with traditional open surgery,modified small incision resection is more effective in the treatment of thyroid tumor,and has less influence on the stress response and immune function of patients.

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更新日期/Last Update: 2021-01-28