[1]谢新静,李忠原.实时剪切波弹性成像联合甲状腺球蛋白抗体检测在甲状腺癌诊断中的应用研究[J].陕西医学杂志,2021,50(2):154-157.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.007]
　XIE Xinjing,LI Zhongyuan.Application of real-time shear wave elastography combined with Tg-Ab detection in diagnosis of thyroid cancer[J].,2021,50(2):154-157.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.007]
点击复制

实时剪切波弹性成像联合甲状腺球蛋白抗体检测在甲状腺癌诊断中的应用研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年2期
页码:
154-157
栏目:
临床研究
出版日期:
2021-02-05

文章信息/Info

Title:
Application of real-time shear wave elastography combined with Tg-Ab detection in diagnosis of thyroid cancer
作者:
谢新静1; 李忠原2
(1.锦州医科大学齐齐哈尔医学院附属第一医院研究生培养基地,黑龙江 齐齐哈尔161041; 2.齐齐哈尔医学院附属第一医院,黑龙江 齐齐哈尔161041)
Author(s):
XIE Xinjing; LI Zhongyuan
(Postgraduate Training Base,the First Affiliated Hospital of Qiqihar Medical College,Jinzhou Medical University,Qiqihar 161041,China)
关键词:
甲状腺癌;  实时剪切波弹性成像;  甲状腺球蛋白抗体;  诊断价值;  对比研究
Keywords:
Thyroid cancer;  Real-time shear wave elastography;  Thyroid globulin antibody;  Diagnostic value;  Comparative study
分类号:
R 736.1
DOI:
DOI:10.3969/j.issn.1000-7377.2021.02.007
文献标志码:
A
摘要:
目的:研究实时剪切波弹性成像(SWE)联合甲状腺球蛋白抗体(Tg-Ab)检测在甲状腺癌诊断中的应用价值。方法:将甲状腺癌患者98例纳入研究,记作甲状腺癌组,另取甲状腺良性疾病患者98例作为良性疾病组; 对所有受试者均进行SWE检查,且以病理检查为金标准,分析SWE检查诊断甲状腺癌的效能; 采集所有受试者的清晨空腹静脉血,获取血清以酶联免疫吸附法检查Tg-Ab水平并对比; 以受试者工作特征(ROC)曲线分析SWE结合血清Tg-Ab水平诊断甲状腺癌的效能; 分析血清Tg-Ab水平与甲状腺癌患者临床病理特征的关系; 比较不同病变患者的血清半乳糖凝集素-1(Gal-1)以及谷胱甘肽过氧化物酶3(GPX3)水平。结果:以病理诊断为金标准,SWE诊断甲状腺癌的灵敏度为83.67%,特异度为78.57%,准确度为81.12%; 甲状腺癌组血清Tg-Ab水平为(120.49±45.82)U/ml,高于良性疾病组的(72.29±31.95)U/ml,差异有统计学意义(t=8.542,P=0.000)。SWE结合血清Tg-Ab水平诊断甲状腺癌的曲线下面积、敏感度以及特异度均高于SWE、血清Tg-Ab水平单独诊断。临床分期为Ⅲ-Ⅳ期的甲状腺患者血清Tg-Ab水平高于Ⅰ-Ⅱ期患者(P<0.05); 而年龄、性别、病灶直径以及淋巴结转移均与血清Tg-Ab水平无关(均P>0.05); 甲状腺癌组血清Gal-1水平高于良性疾病组,而GPX3水平低于良性疾病组(均P<0.05)。结论:SWE结合Tg-Ab检测应用于甲状腺癌诊断中的效能较高,且血清Tg-Ab水平和甲状腺癌患者临床分期密切相关。
Abstract:
Objective:To study the application value of real-time shear wave elastography(SWE)combined with the detection of thyroid globulin antibody(Tg-Ab)in the diagnosis of thyroid cancer.Methods:A total of 98 patients with thyroid cancer were included in the study and recorded as the thyroid cancer group.Another 98 patients with benign thyroid disease at the same time were taken as the benign disease group.SWE examination was performed on all subjects,and pathological examination was used as the gold standard to analyze the efficacy of SWE examination in diagnosing thyroid cancer.In addition,fasting venous blood of all subjects was collected in the morning,and serum was obtained.Tg-Ab levels were examined by enzyme-linked immunosorbent assay and compared.ROC curve was used to analyze the efficacy of SWE combined with serum Tg-Ab level in the diagnosis of thyroid cancer.The relationship between serum Tg-Ab level and clinicopathological characteristics of patients with thyroid cancer was analyzed.Serum levels of galactose agglutinin -1(Gal-1)and glutathione peroxidase 3(GPX3)were compared in patients with different lesions.Results:The sensitivity,specificity and accuracy of SWE in the diagnosis of thyroid cancer were 83.67%,78.57%,81.12%,respectively.Serum Tg-Ab level in the thyroid cancer group was(120.49±45.82)U/ml,which was higher than that in the benign disease group [(72.29±31.95)U/ml],and the difference was statistically significant(t=8.542,P=0.000).The area under the curve,sensitivity and specificity of SWE combined with serum Tg-Ab in the diagnosis of thyroid cancer were higher than SWE and serum Tg-Ab level alone.Serum Tg-Ab level in patients with clinical stage Ⅲ-Ⅳ was higher than that in patients with clinical stageⅠ-Ⅱ(P<0.05).However,age,gender,lesion diameter and lymph node metastasis were not correlated with serum Tg-Ab level(all P>0.05).The serum Gal-1 level of thyroid cancer group was higher than that of benign disease group,while GPX3 level was lower than that of benign disease group(all P<0.05).Conclusion:The efficacy of SWE combined with Tg-Ab in the diagnosis of thyroid cancer is high,and the serum Tg-Ab level is closely related to the clinical stage of thyroid cancer patients.

参考文献/References:

[1] Koseoglu FD,Ozgen SB,Erarslan NA,et al.Does the ACR TI-RADS scoring allow us to safely avoid unnecessary thyroid biopsy? Single center analysis in a large cohort[J].Endocrine,2018,61(3):398-402.
[2] Weiss VL,Andreotti RF,Ely KA.Use of the thyroid imaging,reporting,and data system(TI-RADS)scoring system for the evaluation of subcentimeter thyroid nodules[J].Cancer Cytopathol,2018,126(8):518-524.
[3] 宋 越,谢明星,王 静,等.实时剪切波弹性成像技术鉴别甲状腺良恶性结节的诊断价值及影响因素分析[J].中国医师杂志,2019,21(3):324-326.
[4] 张 艳,罗渝昆,杨 明,等.助力式弹性成像与声触诊组织成像和定量法对甲状腺良恶性结节诊断价值的比较[J].中国医学科学院学报,2019,41(3):383-387.
[5] 陈顺军,宋乐乐,贺军领,等.剪切波弹性成像诊断甲状腺癌术后经131I治疗后颈部淋巴结良恶性的价值[J].中国医学影像学杂志,2019,27(2):128-130.
[6] 江唯希,冉海涛.二维实时剪切波弹性成像技术在肝脏疾病中的研究进展[J].中华医学超声杂志:电子版,2019,16(2):154-157.
[7] 金 金,李建初.超微血管成像技术在甲状腺结节评估中的应用研究现状[J].中华医学超声杂志:电子版,2017,14(11):815-818.
[8] 黄秀红.彩色多普勒超声在甲状腺结节良恶性鉴别中的应用(附824例分析)[J].福建医药杂志,2017,39(6):104-106.
[9] 唐海玲,杨卓文,刘千琪,等.微细血流成像技术在甲状腺良恶性结节鉴别中的价值[J].中国超声医学杂志,2016,32(7):580-582.
[10] Xu Y,Qi X,Zhao X,et al.Clinical diagnostic value of contrast-enhanced ultrasound and TI-RADS classification for benign and malignant thyroid tumors:One comparative cohort study[J].Medicine(Baltimore),2019,98(4):14051-14052.
[11] Gao L,Xi X,Jiang Y,et al.Comparison among TIRADS(ACR TI-RADS and KWAK-TI-RADS)and 2015 ATA Guidelines in the diagnostic efficiency of thyroidnodules[J].Endocrine,2019,64(1):94-96.
[12] Lim-Dunham JE,Toslak IE,Reiter MP,et al.Assessment of the american college of radiology thyroidimaging reporting and data system for thyroid nodulemalignancy risk stratification in a pediatric population[J].AJR,2019,212(1):188-194.
[13] 何志巧,陈玉霞.超声弹性成像在鉴别甲状腺结节良恶性中的影响因素分析[J].中国药物与临床,2020,20(3):361-363.
[14] 杜 晶,韩蕊君,陈翠,等.超声TI-RADS分级联合三维剪切波弹性成像对甲状腺微小癌的诊断效能[J].上海交通大学学报:医学版,2020,40(1):76-80.
[15] 王 珏,闻 卿,贲志飞,等.剪切波弹性成像联合BRAFV600E预测甲状腺乳头状癌中央区淋巴结转移的价值[J].中华医学超声杂志:电子版,2019,16(3):211-216.
[16] 胡紫玥,卢 漫,王 璐,等.三维剪切波弹性成像诊断甲状腺结节良恶性的初步应用[J].中华医学超声杂志:电子版,2020,17(1):11-16.
[17] 李玉平,王伦善.血清TSH,TPOAb和TGAb水平在良恶性甲状腺结节中的鉴别诊断价值[J].现代检验医学杂志,2019,34(5):93-97.
[18] 王永斌,邓智勇,肖世闻,等.分化型甲状腺癌术后抑制状态下血清甲状腺球蛋白水平检测的临床诊断价值[J].现代检验医学杂志,2019,34(5):133-134.
[19] 张 鑫,王 宸,梁 军,等.进展性碘难治性分化型甲状腺癌患者阿帕替尼治疗后血清学与影像学指标变化[J].中国肿瘤临床,2017,44(8):371-376.
[20] 张瀚月,段文冰,张璐璐,等.血清促甲状腺激素和甲状腺过氧化物酶抗体及甲状腺球蛋白抗体在良恶性甲状腺结节鉴别诊断中的临床意义[J].中国医药,2019,14(7):999-1003.
[21] 劳兰玉,唐 妍,谢许萍,等.二维及彩色多普勒超声在囊实性甲状腺癌与结节性甲状腺肿囊性变鉴别诊断中的应用价值[J].陕西医学杂志,2019,48(7):927-929.
[22] 李旭枝,安小莉,董 雯,等.平消胶囊辅助治疗分化型甲状腺癌术后131I放疗患者的临床观察[J].陕西中医,2016,37(4):456-458.

相似文献/References:

[1]陈宏月,李兴江△.甲状腺全切除术对甲状腺癌患者血清血管内皮生长因子、可溶性Fas受体、可溶性Fas受体配体mRNA表达的影响研究[J].陕西医学杂志,2020,49(1):96.
　CHEN Hongyue,LI Xingjiang..Effect of total thyroidectomy on mRNA expression levels of VEGF,sFas and sFasL in serum of patients with thyroid cancer[J].,2020,49(2):96.
[2]林松荣,张 磊,罗金现,等.DNA甲基化修饰在甲状腺癌中的研究进展[J].陕西医学杂志,2021,50(2):254.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.033]
　LIN Songrong,ZHANG Lei,LUO Jinxian,et al.Research progress of DNA methylation in thyroid cancer[J].,2021,50(2):254.[doi:DOI:10.3969/j.issn.1000-7377.2021.02.033]
[3]石维超,张少波.甲状腺癌病理微血管密度与颈部淋巴结转移相关性研究[J].陕西医学杂志,2022,51(11):1449.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.031]
　SHI Weichao,ZHANG Shaobo.Correlation between pathological microvessel density and cervical lymph node metastasis in thyroid cancer[J].,2022,51(2):1449.[doi:DOI:10.3969/j.issn.1000-7377.2022.11.031]
[4]王媛媛,朱 静,刘娜娜,等.溶质载体家族1成员5及谷氨酰胺酶2对人甲状腺癌细胞体外恶性行为的影响及机制研究[J].陕西医学杂志,2023,52(3):344.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.023]
　WANG Yuanyuan,ZHU Jing,LIU Nana,et al.Effect of solute carrier family 1 member 5 and glutaminases 2 on malignant behavior of human thyroid cancer cells in vitro and its mechanism[J].,2023,52(2):344.[doi:DOI:10.3969/j.issn.1000-7377.2023.03.023]

更新日期/Last Update: 2021-01-28