[1]白 健,赵言鹏,王仁一,等.白细胞介素-17基因多态性与类风湿关节炎易感性关系Meta分析[J].陕西医学杂志,2021,50(1):117-122.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.031]
　BAI Jian,ZHAO Yanpeng,WANG Renyi,et al.Relationship between interleukin(IL)-17 gene polymorphism and rheumatoid arthritis susceptibility: a Meta-analysis[J].,2021,50(1):117-122.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.031]
点击复制

白细胞介素-17基因多态性与类风湿关节炎易感性关系Meta分析
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
117-122
栏目:
Meta分析
出版日期:
2021-01-05

文章信息/Info

Title:
Relationship between interleukin(IL)-17 gene polymorphism and rheumatoid arthritis susceptibility: a Meta-analysis
作者:
白 健1; 赵言鹏1; 王仁一1; 高 扬2; 王瀚洲2; 朱光昭3; 杨豫正1; 韩晓晨4; 石 白5; 王西西1; 杨征征6; 王海隆7
(1.贵州中医药大学,贵州 贵阳 550025; 2.中国中医科学院广安门医院,北京 100053; 3.青海省中医院,青海 西宁 810000; 4.北京丰盛中医骨伤专科医院,北京 100034; 5.中国中医科学院广安门医院南区内分泌科,北京 102600; 6.中国中医科学院,北京 100700; 7.北京中医药大学东直门医院,北京 100700)
Author(s):
BAI Jian; ZHAO Yanpeng; WANG Renyi; GAO Yang; WANG Hanzhou; ZHU Guangzhao; YANG Yuzheng; HAN Xiaochen; SHI Bai; WANG Xixi; YANG Zhengzheng; WANG Hailong
(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)
关键词:
白细胞介素-17;  基因多态性;  基因模型;  类风湿关节炎;  Meta分析
Keywords:
IL-17;  Gene polymorphisms;  Gene model;  Rheumatoid arthritis;  Meta analysis
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.031
文献标志码:
A
摘要:
目的:评价白细胞介素(IL)-17基因多态性与类风湿关节炎(RA)易感性的关系。方法:检索2020年8月之前中国知网、维普数据库、万方数据库、PubMed、ClinicalTrials、Google Scholar、Cochrane Library等中英文数据库中已发表的关于IL-17基因多态性与RA易感性关系的文献,采用RevMan 5.3统计学软件进行Meta分析。结果:最终纳入12篇文献进行Meta分析,包含RA患者2573例,健康对照者2651例。Meta分析结果显示,IL-17A基因rs2275913位点多态性在等位基因模型(A对G)、纯合子模型(AA对GG)、隐性模型(AA 对AG+GG)均与RA易感性显著相关。IL-17F基因rs7637803位点多态性在5种模型(等位基因模型、纯合子模型、杂合子模型、显性模型和隐性模型)均与RA易感性相关。IL-17F基因rs2397084位点多态性与RA易感性无明显相关。结论:IL-17A rs2275913及IL-17F rs763780基因多态性与RA易感性显著相关,IL-17F rs2397084基因多态性与RA易感性无明显相关。
Abstract:
Objective:To evaluate the relationship between interleukin(IL)-17 gene polymorphism and rheumatoid arthritis(RA)susceptibility.Methods:The literature published by CNKI,Weipu Database,Wanfang Database,PubMed,ClinicalTrials,Google Scholar,Cochrane Library before August 2020 on the relationship between IL-17 gene polymorphism and RA susceptibility was searched.RevMan 5.3 statistical software was used for Meta analysis.Results:12 literature was included for Meta analysis,including 2573 patients with RA and 2651 healthy controls.Meta analysis results showed that the IL-17A gene rs2275913 polymorphism was associated with RA susceptibility in allele models(A vs.G),homozygous models(AA vs.GG),and recessive models(AA vs.AG+GG).The IL-17F gene rs7637803 polymorphism was associated with RA susceptibility in 5 models(allele model,homozygous model,heterozygous model,dominant model and recessive model).The IL-17F gene rs2397084 polymorphism had no obvious correlation with RA susceptibility.Conclusion:IL-17A rs2275913 and IL-17F rs763780 gene polymorphisms are significantly related to RA susceptibility,while IL-17F rs2397084 gene polymorphisms is not significantly related to RA susceptibility.

参考文献/References:

[1] 刘昌莲,贺冬冬,李晓明,等.艾拉莫德治疗类风湿关节炎疗效及对患者免疫炎症因子水平和骨代谢指标的影响[J].陕西医学杂志,2020,49(5):603-607.
[2] Trieb K.Treatment of the wrist in rheumatoid arthritis[J].J Hand Surg Am,2008,33(1):113-123.
[3] Badge R,Kailash K,Dickson DR,et al.Medium-term outcomes of the Universal-2 total wrist arthroplasty in patients with rheumatoid arthritis[J].Bone Joint J,2016,98(12):1642-1647.
[4] 巩 勋,姜 泉,韩 曼,等.类风湿关节炎患者临床诊断相关特征研究[J].中国中医骨伤科杂志,2020,28(5):10-13,17.
[5] 王翰洲,朱光昭,杨豫正,等.雷公藤多苷片治疗类风湿关节炎作用于IL-23/IL-17轴相关细胞因子的系统评价和meta分析[J].中国医药导报,2020,17(12):128-132,160.
[6] Lubberts E.The IL-23-IL-17 axis in inflammatory arthritis[J].Nat Rev Rheumatol,2015,11(7):415-429.
[7] Al-Saadany HM,Hussein MS,Gaber RA,et al.Th-17 cells and serum IL-17 in rheumatoid arthritis patients: correlation with disease activity and severity[J].Egypt Rheumatol,2016,38:1-7.
[8] Amett FC,Edworthy SM,Block DA,et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis[J].Arthritis Rheum,1988,31(3):315-324.
[9] Aletaha D,Neogi T,Silman AJ,et al.2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative[J].Ann Rheum Dis,2010,69(9):1580-1588.
[10] Stang A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605.
[11] Bogunia-Kubik K,Swierkot J,Malak A,et al.IL-17A,IL-17F and IL-23R gene polymorphisms in polish patients with rheumatoid arthritis[J].Arch Immunol Ther Exp(Warsz),2015,63(3):215-221.
[12] Gomesda Silva IIF,Angelo HD,Rushansky E,et al.Interleukin(IL)-23 receptor,IL-17A and IL-17F gene polymorphisms in brazilian patients with rheumatoid arthritis[J].Arch Immunol Ther Exp(Warsz),2017,65(6):537-543.
[13] Marwa OS,Kalthoum T,Wajih K,et al.Association of IL17A and IL17F genes with rheumatoid arthritis disease and the impact of genetic polymorphisms on response to treatment[J].Immunol Lett,2017,183:24-36.
[14] Pawlik A,Kotrych D,Malinowski D,et al.IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis[J].BMC Musculoskelet Disord,2016,17:208.
[15] Louahchi S,Allam I,Berkani L,et al.Association study of single nucleotide polymorphisms of IL23R and IL17 in rheumatoid arthritis in the Algerian population[J].Acta Reumatol Port,2016,41(2):151-157.
[16] Carvalho CN,Do Carmo RF,Duarte AL,et al.IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren's syndrome[J].Clin Oral Investig,2016,20(3):495-502.
[17] Dhaouadi T,Chahbi M,Haouami Y,et al.IL-17A,IL-17RC polymorphisms and IL-17 plasma levels in Tunisian patients with rheumatoid arthritis[J].PLoS One,2018,13(3):e0194883.
[18] 罗彩林,郑晨娜,饶华春,等.IL-17A与IRF-5遗传多态性与泉州地区类风湿关节炎相关性研究[J].世界复合医学,2017,3(3):12-16,20.
[19] Shen L,Zhang H,Yan T,et al.Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population[J].Gene,2015,566(1):18-22.
[20] 邓燕群,刘翠玉,尹志华,等.类风湿关节炎患者血清中IL-17表达及IL-17F基因位点rs763780多态性分析[J].中国免疫学杂志,2020,36(2):222-225.
[21] Nisar H,Pasha U,Mirza MU,et al.Impact of IL-17F 7488T/C functional polymorphism on progressive rheumatoid arthritis: novel insight from the molecular dynamic simulations[J].Immunol Invest,2020,16:1-11.
[22] Paradowska-Gorycka A,Wojtecka-Lukasik E,Trefler J,et al.Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis(RA)[J].Scand J Immunol,2010,72(2):134-141.
[23] 戴 璐,宋欣丽,王 健.青藤碱联合甲氨蝶呤对类风湿性关节炎患者血清炎症因子的影响及治疗安全性分析[J].陕西医学杂志,2018,47(12):1580-1583.
[24] Lee YH,Bae SC.Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis[J].Postgrad Med J,2017,93(1102):465-471.
[25] 陈 萍,李亮亮,梁申菊,等.IL-17F基因多态性与类风湿关节炎发病风险关系的Meta分析[J].中国免疫学杂志,2017,33(8):1218-1222.

相似文献/References:

[1]张晓燕,吴守振,刘春风,等.川崎病患者糖皮质激素受体、IL-17A、IL-6检测的临床意义[J].陕西医学杂志,2016,(10):1392.
[2]张慧贤,马向明,付庆江,等.肝细胞癌患者血清IL-17细胞因子水平检测的临床意义[J].陕西医学杂志,2016,(10):1394.
[3]李 垚,陈万林,杨 平,等.亚甲基四氢叶酸还原酶基因C677T多态性与冠心病患者冠状动脉病变及叶酸水平相关性研究[J].陕西医学杂志,2021,50(1):22.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.005]
　LI Yao,CHEN Wanlin,YANG Ping,et al.Correlation of methylenetetrahydrofolate reductase gene C677T polymorphism with coronary artery disease and folic acid level in patients with coronary heart disease[J].,2021,50(1):22.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.005]
[4]王 雄,高芳芳,贺 峰.儿茶酚胺氧位甲基转移酶Val158met基因多态性与榆林地区妇科患者术后芬太尼镇痛效应关系研究[J].陕西医学杂志,2021,50(8):992.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.022]
　WANG Xiong,GAO Fangfang,HE Feng.Relationship between COMT Val158met gene polymorphism and analgesic effect of fentanyl in gynecological postoperative patients in Yulin area[J].,2021,50(1):992.[doi:DOI:10.3969/j.issn.1000-7377.2021.08.022]
[5]何玉兰,白春英.卒中后认知障碍与亚甲基四氢叶酸还原酶基因多态性关系研究[J].陕西医学杂志,2021,50(11):1387.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.016]
　HE Yulan,BAI Chunying.Relationship between post-stroke cognitive impairment and polymorphisms of MTHFR gene[J].,2021,50(1):1387.[doi:DOI:10.3969/j.issn.1000-7377.2021.11.016]
[6]许 璐,白春英,陈士萍,等.早发冠心病患者载脂蛋白E基因多态性分析及其与冠状动脉病变严重程度关系研究[J].陕西医学杂志,2022,51(9):1090.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.010]
　XU Lu,BAI Chunying,CHEN Shiping,et al.Analysis of ApoE gene polymorphisms and their relationship with severity of coronary artery lesions in patients with premature coronary artery disease[J].,2022,51(1):1090.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.010]
[7]周 卓,穆宝妮,冯思思,等.胆固醇7α-羟化酶基因与妊娠期增重及妊娠结局相关性研究[J].陕西医学杂志,2023,52(8):992.[doi:DOI:10.3969/j.issn.1000-7377.2023.08.011]
[8]梁 娜,张泽天,孙晓冉,等.低密度脂蛋白相关受体蛋白6基因多态性与非酒精性脂肪性肝病发病关系研究[J].陕西医学杂志,2023,52(9):1241.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.030]
　LIANG Na,ZHANG Zetian,SUN Xiaoran,et al.Relationship between low-density lipoprotein receptor-related protein 6 gene polymorphism and occurrence of nonalcoholic fatty liver disease[J].,2023,52(1):1241.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.030]
[9]金银浩,刘桂清.载脂蛋白AⅡ基因-265T/C多态性与冠心病患者脂类代谢及冠脉狭窄程度相关性研究[J].陕西医学杂志,2023,52(10):1331.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.010]
　JIN Yinhao,LIU Guiqing.Correlation between apolipoprotein AⅡ gene 265T/C polymorphism and lipid metabolism and degree of coronary stenosis in patients with coronary heart disease[J].,2023,52(1):1331.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.010]
[10]武文娟,韩 伟.白细胞介素-6-572C-G基因多态性与小儿复杂型热性惊厥及症状发作后脑损伤关系临床研究[J].陕西医学杂志,2023,52(10):1371.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.019]
　WU Wenjuan,HAN Wei.Relationship between IL-6 gene polymorphism and complex febrile seizures and post seizure brain damage in children[J].,2023,52(1):1371.[doi:DOI:10.3969/j.issn.1000-7377.2023.10.019]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助面上项目(81673804)
更新日期/Last Update: 2021-01-05