[1]刘玲娇,余湘尤,虢小丽.西安市职业人群非酒精性脂肪性肝病患病率及其危险因素调查研究[J].陕西医学杂志,2021,50(1):107-110.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.029]
　LIU Lingjiao,YU Xiangyou,GUO Xiaoli.Prevalence and risk factors of nonalcoholic fatty liver disease among occupational population in Xi'an[J].,2021,50(1):107-110.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.029]
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西安市职业人群非酒精性脂肪性肝病患病率及其危险因素调查研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
107-110
栏目:
调查研究
出版日期:
2021-01-05

文章信息/Info

Title:
Prevalence and risk factors of nonalcoholic fatty liver disease among occupational population in Xi'an
作者:
刘玲娇; 余湘尤; 虢小丽
(陕西省人民医院内分泌代谢科,陕西 西安 710068)
Author(s):
LIU Lingjiao; YU Xiangyou; GUO Xiaoli
(Department of Endocrinology and Metabolism,Shaanxi Provincial People's Hospital,Xi'an 710068,China)
关键词:
非酒精性脂肪性肝病;  职业人群;  患病率;  危险因素;  血糖;  血脂
Keywords:
Nonalcoholic fatty liver disease;  Occupational population;  Prevalence;  Risk factors;  Blood glucose;  Blood lipids
分类号:
R 589.2
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.029
文献标志码:
A
摘要:
目的:了解西安市职业人群非酒精性脂肪性肝病(NAFLD)的患病率及其危险因素,为NAFLD的防治提供参考依据。方法:纳入职业人群6422例,根据是否患有NAFLD分为NAFLD组(2038例)和非NAFLD组(4384例)。比较不同年龄及性别人群NAFLD患病率情况,NAFLD组和非NAFLD组一般资料及生化指标,分析NAFLD危险因素。结果:检出NAFLD患者2038例,总患病率31.73%; 男性NAFLD患病率显著高于女性(34.66%与16.47%,P<0.001); 女性20～29岁组NAFLD患病率低于其他年龄组(P<0.001); 男性不同年龄组间NAFLD患病率比较差异无统计学意义(P>0.05)。NAFLD组男女比例、年龄、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、腰围均高于非NAFLD组(均P<0.001)。与非NAFLD组相比,NAFLD组空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)及尿酸(UA)升高,高密度脂蛋白胆固醇(HDL-C)降低(均P<0.05)。Logistic回归分析结果提示男性、肥胖(BMI及腰围)、代谢紊乱(血糖、血脂及尿酸水平)是影响NAFLD的独立危险因素。结论:西安市职业人群NAFLD患病率较高,其中男性、肥胖(BMI及腰围)、代谢紊乱(血糖、血脂及尿酸水平)是影响NAFLD的独立危险因素。
Abstract:
Objective:To understand the prevalence and risk factors of nonalcoholic fatty liver disease(NAFLD)among occupational population in Xi'an,and to provide reference basis for the prevention and treatment of NAFLD.Methods:A total of 6422 occupational workers were included and divided into NAFLD group(2038 cases)and non-NAFLD group(4384 cases)according to whether they had NAFLD.The prevalence of NAFLD among people of different ages and genders,the general data and biochemical indicators of NAFLD group and non-NAFLD group were compared.The risk factors of NAFLD were analyzed.Results:A total of 2038 NAFLD patients were detected,with a total prevalence of 31.73%; the prevalence of NAFLD in the male group was significantly higher than that in the female group(34.66% vs.16.47%,P<0.001); the prevalence of NAFLD in women aged 20-29 years was lower than that in other age groups(P<0.001); there was no statistically significant difference in the prevalence of NAFLD among different age subgroups in the male group(P>0.05).The ratio of male to female,age,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),and waist circumference in the NAFLD group were higher than those in the non-NAFLD group(all P<0.001).Compared with the non-NAFLD group,FBG,TG,TC,LDL-C,Hcy and UA were increased and HDL-C was decreased in the NAFLD group(All P<0.05).The Logistic regression analysis suggested that male,obesity(BMI and waist circumference),and metabolic disorders(blood glucose,blood lipids and uric acid levels)were independent risk factors for NAFLD.Conclusion:The prevalence of NAFLD among occupational groups in Xi'an is high,among which male,obesity(BMI and waist circumference),and metabolic disorders(blood glucose,blood lipids and uric acid levels)are independent risk factors for NAFLD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81700735)
更新日期/Last Update: 2021-01-05