[1]渊 潭,李今朝.老年冠心病患者经皮冠状动脉介入术术后应用低剂量替格瑞洛的可行性及安全性研究[J].陕西医学杂志,2021,50(1):86-88,92.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.023]
　YUAN Tan,LI Jinzhao.Feasibility and safety of low dose ticagrelor after percutaneous coronary intervention in elderly patients with coronary heart disease[J].,2021,50(1):86-88,92.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.023]
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老年冠心病患者经皮冠状动脉介入术术后应用低剂量替格瑞洛的可行性及安全性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
86-88,92
栏目:
药物与临床
出版日期:
2021-01-05

文章信息/Info

Title:
Feasibility and safety of low dose ticagrelor after percutaneous coronary intervention in elderly patients with coronary heart disease
作者:
渊 潭; 李今朝
(锦州医科大学附属第一医院心内科,辽宁 锦州 121001)
Author(s):
YUAN Tan; LI Jinzhao
(Department of Cardiology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
关键词:
冠心病;  老年人;  经皮冠状动脉介入术;  替格瑞洛;  可行性;  安全性
Keywords:
Coronary heart disease;  Elderly;  Percutaneous coronary intervention;  Ticagrelor;  Feasibility;  Safety
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.023
文献标志码:
A
摘要:
目的:观察经皮冠状动脉介入术(PCI)术后辅助应用替格瑞洛在治疗老年冠心病的可行性及安全性。方法:选取老年冠心病患者120例,将入组病人随机分为对照组和低剂量组,每组60例。两组病人PCI术后均口服阿司匹林; 对照组给予替格瑞洛180 mg/d,分2次口服; 低剂量组给予替格瑞洛90 mg/d,分2次口服。比较两组病人治疗前后二磷酸腺苷(ADP)诱导的血小板聚集率、凝血功能状态、主要心血管不良事件(MACE)发生率及出血事件发生率。结果:两组治疗后ADP诱导血小板聚集率均明显低于治疗前(P<0.05); 低剂量组治疗后ADP诱导血小板聚集率与对照组比较,差异无统计学意义(P>0.05)。两组患者在治疗前和治疗后凝血酶原时间(PT)、纤维蛋白原(FIB)、血小板最大聚集率(MPAR)水平间比较均无统计学差异(P>0.05); 治疗后,两组患者凝血酶原时间、纤维蛋白原均较治疗前显著提高,血小板最大聚集率与治疗前相比显著降低,差异具有统计学意义(P<0.05)。两组患者MACE发生率比较,差异无统计学意义(P>0.05); 低剂量组病人发生出血事件率显著低于对照组,比较差异具有统计学意义(P<0.05)。结论:PCI术后90 mg/d替格瑞洛口服辅助治疗老年冠心病患者可有效预防出血事件发生,且未增加MACE风险,是安全可行的。
Abstract:
Objective:To observe the feasibility and safety of ticagrelor after percutaneous coronary intervention(PCI)in the treatment of elderly coronary heart disease.Methods:120 elderly patients with coronary heart disease were randomly divided into control group and low-dose group,60 patients in each group.Both groups of patients received oral aspirin after PCI.The control group was given ticagrelor 180 mg/d orally in 2 times.The low-dose group was given ticagrelor 90 mg/d orally in 2 times.The platelet aggregation rate induced by adenosine diphosphate(ADP),coagulation function status,incidence of major cardiovascular adverse events(MACE)and incidence of bleeding events were compared between the two groups before and after treatment.Results:After treatment,the platelet aggregation rate induced by ADP in the two groups was significantly lower than before treatment(P<0.05).There was no significant difference in the platelet aggregation rate induced by ADP after treatment between the two groups(P>0.05).There was no significant difference in the levels of prothrombin time(PT),fibrinogen(FIB),and maximum platelet aggregation rate(MPAR)between the two groups before and after treatment(P>0.05).After treatment,the PT and FIB of the two groupos were significantly higher than those before treatment,and MPAR was significantly lower than that before treatment(P<0.05).There was no statistical difference in the incidence of MACE between the two groups(P>0.05).The bleeding event rate of patients in the low-dose group was significantly lower than that in the control group(P<0.05).Conclusion:Oral adjuvant treatment of ticagrelor at 90 mg/d after PCI can effectively prevent bleeding events in elderly patients with coronary heart disease without increasing the risk of MACE.It is safe and feasible.

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更新日期/Last Update: 2021-01-05