[1]麦海星,张景云,左世栋,等.绿激光联合二甲基亚砜膀胱灌注治疗出血性膀胱炎疗效研究[J].陕西医学杂志,2021,50(1):71-74.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.019]
　MAI Haixing,ZHANG Jingyun,ZUO Shidong,et al.Combination of intravesical DMSO instillation and PVP in the treatment of radiation-induced hemorrhagic cystitis[J].,2021,50(1):71-74.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.019]
点击复制

绿激光联合二甲基亚砜膀胱灌注治疗出血性膀胱炎疗效研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
71-74
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Combination of intravesical DMSO instillation and PVP in the treatment of radiation-induced hemorrhagic cystitis
作者:
麦海星; 张景云; 左世栋; 孔令生; 董金凯; 曲 楠; 陈立军
(解放军总医院第五医学中心泌尿外科,北京 100071)
Author(s):
MAI Haixing; ZHANG Jingyun; ZUO Shidong; KONG Lingsheng; DONG Jinkai; QU Nan; CHEN Lijun
(Urology Department,Fifth Medical Center of PLA General Hospital,Beijing 100071,China)
关键词:
激光;  二甲基亚砜;  膀胱灌注;  高压氧;  出血性膀胱炎;  放射性损伤
Keywords:
Green laser;  Dimethyl sulfoxide;  Intravesical instillation;  Hyperbaric oxygen;  Hemorrhagic cystitis;  Radiation damage
分类号:
R 694.3
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.019
文献标志码:
A
摘要:
目的:评估绿激光联合二甲基亚砜(DMSO)膀胱灌注治疗出血性膀胱炎(HC)的临床疗效。方法:对26例因盆腔恶性肿瘤行放射治疗的患者进行膀胱内绿激光止血联合DMSO膀胱灌注治疗。在治疗前后及12个月随访期间评估并比较血尿、尿频和盆腔疼痛评分(0～10)。结果:所有患者均能够完成手术治疗,膀胱内DMSO灌注未见明显副反应。在为期6～12个月随访期间内,治疗后6个月疼痛学评分,尿频及血尿症状均有明显缓解,但是在部分患者第12个月随访期间有血尿复发症状。结论:绿激光联合DMSO膀胱灌注治疗HC在治疗放射性膀胱炎上疗效与高压氧类似。其耐受性好,能够在12个月的时间内持续减少膀胱出血、盆腔痛以及尿频症状的发生。
Abstract:
Objective:To evaluate the clinical efficacy of green laser combined with dimethyl sulfoxide(DMSO)intravesical instillation in the treatment of hemorrhagic cystitis(HC).Methods:26 patients with pelvic malignant tumor were treated with intravesical green laser hemostasis combined with DMSO intravesical instillation.Hematuria,frequent urination and pelvic pain scores(0-10)were evaluated and compared before and after treatment during an 12-month follow-up.Results:All patients were able to complete the operation,and no obvious side effect was found by intravesical infusion of DMSO.During the 6-12-month follow-up,pain score,frequent urination and hematuria were significantly relieved 6 months after treatment,but some patients had recurrent hematuria during the 12th month follow-up.Conclusion:The efficacy of green laser combined with DMSO intravesical instillation in the treatment of HC is similar to hyperbaric oxygen.It is well tolerated and can continuously reduce the occurrence of bladder bleeding,pelvic pain and frequent urination within 12 months.

参考文献/References:

[1] Jepsen C,Turkiewicz D,Ifversen M,et al.Low incidence of hemorrhagic cystitis following ex vivo T-cell depleted haploidentical hematopoietic cell transplantation in children[J].Bone Marrow Transplant,2020,55(1):207-214.
[2] 武 倩,周 芳,宋宁霞,等.异基因造血干细胞移植后出血性膀胱炎的临床特征及高危因素分析[J].中华血液学杂志,2019,40(3):187-190.
[3] 巫嘉文,余 洋.高压氧综合治疗出血性放射性膀胱炎56例疗效观察[J].中华航海医学与高气压医学杂志,2016,23(4):323-325.
[4] 林 斌.二甲基亚砜通过降低炎症和氧化应激改善硫酸鱼精蛋白诱导的大鼠膀胱炎[D].重庆:第三军医大学,2015:1-49.
[5] 殷卓敏,俞 华.放化疗所致出血性膀胱炎的治疗进展[J].国际肿瘤学杂志,2014,41(12):934-937.
[6] Kawamura N,Kakuta Y,Fukuhara S,et al.Successful treatment of hemorrhagic cystitis after radiation therapy with intravesical instillation of aluminium hydroxide gel and magnesium hydroxide:report of a case[J].Hinyokika Kiyo,2008,54(3):239-241.
[7] 李前进,马惠斌,郑双峰,等.经尿道膀胱黏膜电凝术联合甲醛溶液灌注治疗出血性放射性膀胱炎的临床效果[J].医学信息,2019,32(9):187-188.
[8] 张 涛,王芳芳.硝酸银灌注治疗出血性放射性膀胱炎[J].航空航天医学杂志,2011,22(11):1330-1331.
[9] Laszlo D,Bosi A,Guidi S,et al.Prostaglandin E2 bladder instillation for the treatment of hemorrhagic cystitis after allogeneic bone marrow transplantation[J].Haematologica,1995,80(5):421-425.
[10] 孙 新,李栋方,郝文革,等.结合雌激素治疗儿童造血干细胞移植后出血性膀胱炎[J].岭南急诊医学杂志,2007,12(4):285-287.
[11] Tanaka J,Yamaguchi K,Ishikura H,et al.Bladder pain relief by HMGB1 neutralization and soluble thrombomodulin in mice with cyclophosphamide-induced cystitis[J].Neuropharmacology,2014,19(79):112-118.
[12] 杨 波,王 起,王 茜,等.膀胱镜下电凝止血治疗儿童异基因造血干细胞移植后迟发性出血性膀胱炎[J].中华小儿外科杂志,2019,40(2):143-147.
[13] Bevers RF,Bakker DJ,Kurth KH.Hyperbaric oxygen treatment for haemorrhagic radiation cystitis[J].Lancet,1995,346(78):803-805.
[14] Chong SJ,Kan EM,Song C,et al.Characterization of early thermal burns and the effects of hyperbaric oxygen treatment:a pilot study[J].Diving Hyperb Med,2013,43(3):157-161.
[15] Feldmeier J,Carl U,Hartmann K,et al.Hyperbaric oxygen:does it promote growth or recurrence of malignancy[J].Undersea Hyperb Med,2003,30(1):1-18.

更新日期/Last Update: 2021-01-05