[1]杨凯祥,牛玉军.冠心病斑块易损性及预后与血小板/淋巴细胞比值及中性粒细胞/淋巴细胞比值相关性研究[J].陕西医学杂志,2021,50(1):44-47.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.011]
　YANG Kaixiang,NIU Yujun.Correlation between plaque vulnerability,prognosis of coronary heart disease and PLR and NLR[J].,2021,50(1):44-47.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.011]
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冠心病斑块易损性及预后与血小板/淋巴细胞比值及中性粒细胞/淋巴细胞比值相关性研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
44-47
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Correlation between plaque vulnerability,prognosis of coronary heart disease and PLR and NLR
作者:
杨凯祥; 牛玉军
(锦州医科大学附属第一医院放射科,辽宁 锦州 121000)
Author(s):
YANG Kaixiang; NIU Yujun
(Department of Radiology,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China)
关键词:
冠心病;  中性粒细胞/淋巴细胞比值;  血小板/淋巴细胞比值;  斑块易损性;  预后
Keywords:
Coronary heart disease;  Neutrophil to lymphocyte ratio;  Platelet to lymphocyte ratio;  Plaque vulnerability;  Prognosis
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.011
文献标志码:
A
摘要:
目的:探讨冠心病(CHD)患者血小板/淋巴细胞比值(PLR)和中性粒细胞/淋巴细胞比值(NLR)对冠状动脉斑块易损性及预后的影响。方法:收集CHD患者96例(CHD组),按照冠状动脉斑块性质分组(稳定组40例,易损组56例); 选择同期行冠脉CTA检查结果显示无斑块形成者46例(对照组)。收集一般材料及检测血生化数据,应用Logistic回归分析CHD患者冠状动脉斑块易损的影响因素及其对预后有判断价值。结果:较对照组,CHD组血小板(PLT)、中性粒细胞(NE)、淋巴细胞(LYM)、嗜酸性粒细胞(EO)比较的差异有统计学意义(均P<0.05)。PLR(P=0.002)、NLR(P=0.008)均影响冠状动脉斑块的易损性,高PLR组及高NLR组发生不良心血管事件(MACE)的比例分别明显高于低PLR组及低NLR组,差异有统计学意义(均P<0.005)。结论: PLR和NLR是CHD患者冠脉斑块易损性的独立危险因素,且与预后联系紧密,且为临床诊疗提供了理论支撑及新的治疗靶点。
Abstract:
Objective:To investigate the effect of platelet/lymphocyte ratio(PLR)and neutrophil/lymphocyte ratio(NLR)on coronary plaque vulnerability and prognosis in patients with coronary heart disease(CHD).Methods:96 patients with CHD(CHD group)were collected and grouped according to the nature of coronary plaque(40 cases in stable group and 56 cases in vulnerable group).The result of coronary CTA examination in the same period showed that 46 patients were normal(control group).General data and blood biochemical data were collected,and Logistic regression was used to analyze the risk factors of coronary plaque vulnerability in CHD patients and their prognostic value.Results:There were significant differences in PLT,NE,LYM and EO between CHD group and control group(P<0.05).PLR and NLR affected the vulnerability of coronary artery plaque,and high PLR group and high NLR group had higher proportion of MACE than low PLR group and low NLR group(P<0.005).Conclusion:PLR and NLR are independent risk factors for coronary plaque vulnerability in CHD patients,and are closely related to the prognosis,and provide theoretical support and new therapeutic targets for clinical diagnosis and treatment.

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更新日期/Last Update: 2021-01-05