[1]李 莹,纪玉强,蔡 琴,等.晚期糖基化终产物在老年心房颤动患者血清中的表达及意义[J].陕西医学杂志,2021,50(1):29-31.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.007]
　LI Ying,JI Yuqiang,CAI Qin,et al.Expression and significance of advanced glycosylation end products in serum of elderly patients with atrial fibrillation[J].,2021,50(1):29-31.[doi:DOI:10.3969/j.issn.1000-7377.2021.01.007]
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晚期糖基化终产物在老年心房颤动患者血清中的表达及意义
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
50
期数:
2021年1期
页码:
29-31
栏目:
临床研究
出版日期:
2021-01-05

文章信息/Info

Title:
Expression and significance of advanced glycosylation end products in serum of elderly patients with atrial fibrillation
作者:
李 莹; 纪玉强; 蔡 琴; 李晨辉
(西安市第一医院心内科,陕西 西安 710002)
Author(s):
LI Ying; JI Yuqiang; CAI Qin; LI Chenghui
(Department of Cardiology,Xi'an No.1 Hospital,Xi'an 710002,China)
关键词:
晚期糖基化终末产物;  羧甲基赖氨酸;  心房颤动;  老年;  氧化应激;  炎性因子
Keywords:
Advanced glycation end products;  Carboxymethyllsine;  Atrial fibrillation;  Aging;  Oxidative stress;  Inflammation factor
分类号:
R 541.75
DOI:
DOI:10.3969/j.issn.1000-7377.2021.01.007
文献标志码:
A
摘要:
目的:探讨老年持续性心房颤动患者血清晚期糖基化终产物羧甲基赖氨酸(CML)、超氧化物歧化酶(SOD)、肿瘤坏死因子-α(TNF-α)的水平变化,并探讨其临床意义。方法:选择老年心房颤动患者50例(年龄≥65岁),对照组为同期住院的年龄≥65岁非心房颤动患者30例。用ELISA法检测血CML、SOD、TNF-α的水平。彩色多普勒超声检测左心室射血分数(LVEF)、左心房内径。结果:与对照组相比,老年心房颤动组血清CML、TNF-α均明显升高(均P<0.05),血清SOD较对照组降低(P<0.05),LVEF和左心房内径亦较对照组显著升高(均P<0.05)。结论:晚期糖基化终末产物是促使老年心房颤动发生的一种重要生物物质,有可能通过氧化应激参与了房颤的病理生理过程。
Abstract:
Objective:To investigate the changes in serum levels of advanced glycation end products carboxymethyllysine(CML),superoxide dismutase(SOD)and tumor necrosis factor-α(TNF-α)in elderly patients with persistent atrial fibrillation,and to explore its clinical significance.Methods:50 elderly patients with atrial fibrillation(age ≥65 years)were selected as the elderly atrial fibrillation group,and and 30 non-atrial fibrillation patients aged ≥ 65 years who were hospitalized during the same period were selected as the control group.The levels of serum CML,SOD,and TNF-α were detected by ELISA.Color Doppler ultrasound was used to detect LVEF and left atrium inner diameter.Results:Compared with the control group,the serum CML and TNF-α of the elderly atrial fibrillation group were significantly increased(all P<0.05),and the serum SOD was lower(P<0.05),and the LVEF and left atrial diameter were higher(all P<0.05).Conclusion:The advanced glycation end products are an important biological substance that promotes the occurrence of elderly atrial fibrillation,and may participate in the pathophysiological process of atrial fibrillation through oxidative stress.

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备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2018SF-130); 西安市科技计划项目[201805094YX2SF28(8)]
更新日期/Last Update: 2021-01-05