[1]焦文妤,高爱华△.血清可溶性髓系细胞触发受体-1与临床肺部感染评分在慢性阻塞性肺疾病呼吸机相关性肺炎早期诊断及预后判断中的效能研究[J].陕西医学杂志,2020,49(12):1630-1633，1637.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.024]
　JIAO Wenyu,GAO Aihua..Effectiveness of sTREM-1 and CPIS in early diagnosis and prognosis judgment of ventilator-associated pneumonia in COPD[J].,2020,49(12):1630-1633，1637.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.024]
点击复制

血清可溶性髓系细胞触发受体-1与临床肺部感染评分在慢性阻塞性肺疾病呼吸机相关性肺炎早期诊断及预后判断中的效能研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年12期
页码:
1630-1633，1637
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Effectiveness of sTREM-1 and CPIS in early diagnosis and prognosis judgment of ventilator-associated pneumonia in COPD
作者:
焦文妤1; 高爱华2△
1.西安大兴医院(西安 710016); 2.空军第986医院(西安 710054)
Author(s):
JIAO Wenyu; GAO Aihua.
Xi'an Daxing Hospital(Xi'an 710016)
关键词:
慢性阻塞性肺疾病;  机械通气;  呼吸机相关性肺炎;  可溶性髓系细胞触发受体-1;  临床肺部感染评分
Keywords:
Chronic obstructive pulmonary disease;  Mechanical ventilation;  Ventilator-associated pneumonia;  Soluble myeloid cell triggered receptor-1;  Clinical pulmonary infection score
分类号:
R563.1
DOI:
DOI:10.3969/j.issn.1000-7377.2020.12.024
文献标志码:
A
摘要:
目的:探究血清可溶性髓系细胞触发受体-1(sTREM-1)与临床肺部感染评分(CPIS)在慢性阻塞性肺疾病(COPD)呼吸机相关性肺炎(VAP)早期诊断及预后判断中的效能。方法:选择行机械通气治疗的单纯COPD患者72例(非VAP组)和并发VAP 的COPD患者68例(VAP组)作为研究对象。测定非VAP组患者入组第1天、第3天、第7天血清sTREM-1水平和CPIS评分,以及VAP组患者入组第1天、第3天、第7天和出院或死亡当天血清sTREM-1水平和CPIS评分,对比死亡患者和存活患者血清sTREM-1水平和CPIS评分变化。采用受试者工作特征曲线(ROC)研究血清sTREM-1水平和CPIS评分在并发VAP 的COPD诊断和预后预测中的效能。结果:VAP组患者血清sTREM-1水平和CPIS评分均高于非VAP组(P<0.01)。VAP组死亡患者入组第1天、第3天、第7天和死亡或出院当天血清sTREM-1水平和CPIS评分均高于存活患者(P<0.01)。血清sTREM-1水平与CPIS评分联合在并发VAP的COPD患者诊断和预后预测中的效能均高于单独指标的效能。结论:sTREM-1水平和CPIS评分在机械通气COPD患者早期VAP诊断中具有较高价值,动态监测患者两者变化有助于并发VAP的COPD患者的预后判断。
Abstract:
Objective:To investigate the effectiveness of serum soluble myeloid cell trigger receptor-1(sTREM-1)and clinical pulmonary infection score(CPIS)in early diagnosis and prognosis judgment of ventilator-associated pneumonia in chronic obstructive pulmonary disease(COPD).Methods:72 patients with simple COPD(non-VAP group)and 68 patients with COPD complicated with VAP(VAP group)who underwent mechanical ventilation were selected as subjects.The serum sTREM-1 and CPIS scores of the non-VAP group on the first day,third day,seventh day of enrollment were measured.The serum sTREM-1 and CPIS scores of the VAP group on the first day,third day,seventh day of enrollment and the day of discharge or death were determined,and serum sTREM-1 level and CPIS score of dead and survival patients were compared.The receiver operating characteristic curve(ROC)was used to study the effectiveness of serum sTREM-1 level and CPIS score in the diagnosis and prognosis prediction of COPD complicated with VAP.Results:The serum sTREM-1 level and CPIS score of VAP group were higher than those of non-VAP group(P<0.01).The serum sTREM-1 level and CPIS score of the dead patients on the first day,the third day,the seventh day of enrollment and the death or discharge day in VAP group were higher than those in the survival patients(P<0.01).The effectiveness of serum sTREM-1 level combined with CPIS score in the diagnosis and prognosis prediction of COPD patients complicated with VAP was higher than that of single index.Conclusion:The sTREM-1 level and CPIS score have high value in the early diagnosis of COPD VAP patients with mechanical ventilation.Dynamic monitoring of the changes of both is helpful to judge the prognosis of COPD patients complicated with VAP.

参考文献/References:

[1] 杨栓柱,王 文,李 猛,等.千金苇茎汤合瓜蒌薤白杏仁汤治疗慢性阻塞性肺疾病急性加重期临床研究[J].陕西中医,2019,40(5):600-603.
[2] 张小春,吴逢选,张京臣,等.EICU慢性阻塞性肺疾病急性加重期合并血流感染的临床特点分析[J].中国急救复苏与灾害医学杂志,2018,13(4):348-351.
[3] 姜秀霞,王 波,王秀金,等.慢性阻塞性肺疾病急性加重机械通气患者呼吸机相关性肺炎的临床研究[J].中华医院感染学杂志,2015,25(17):126-128.
[4] 李树铁,于慧丹,姜 伟,等.小剂量肝素钠联合红花黄色素对慢性阻塞性肺疾病急性加重期患者机械通气时间和呼吸机相关性肺炎发生率及脱机后住院时间的影响[J].中国医药,2019,14(2):61-63.
[5] 程知音.不同病原菌所致重症肺炎患者白细胞计数、降钙素原、C-反应蛋白及白细胞介素-6水平[J].中华实验和临床感染病杂志:电子版,2018,12(6):100-103.
[6] 谢柏梅,敬 梅,路晓艳,等.CPIS评分及血清PCT在慢性阻塞性肺疾病呼吸机相关性肺炎诊断和预后判断中的应用价值[J].临床和实验医学杂志,2018,17(1):1617-1620.
[7] 王建蓉,丁银环,李 多.血清可溶性髓系细胞触发受体1、降钙素原水平及急性生理学与慢性健康状况评分系统Ⅱ评分对血流感染患者预后的预测价值研究[J].实用心脑肺血管病杂志,2019,27(4):33-37.
[8] 王 辰,迟春花,陈荣昌,等.慢性阻塞性肺疾病基层诊疗指南(实践版?2018)[J].中华全科医师杂志,2018,17(11):871-877.
[9] 施 毅.中国成人医院获得性肺炎与呼吸机相关性肺炎诊断和治疗指南(2018年版)[J].中华结核和呼吸杂志,2018,41(4):255-280.
[10] 祁鑫华.脑状态指数与临床肺部感染评分在脑外伤昏迷合并肺部感染病人预后评估中的应用[J].护理研究,2018,32(4):163-166.
[11] 洪林杰,黄种杰,范洪涛,等.老年慢性阻塞性肺疾病患者合并呼吸机相关性肺炎的病原菌分布变迁及耐药性分析[J].疑难病杂志,2018,17(3):226-229.
[12] 李 林,刘 琴,何兰萍.老年慢性阻塞性肺疾病急性加重期患者发生呼吸机相关性肺炎的危险因素分析[J].中国医刊,2019,54(6):618-621.
[13] 白雅红,李月阳,王 华,等.降钙素原、C反应蛋白、白细胞计数联合检测对医院获得性细菌性肺炎的诊断价值[J].陕西医学杂志,2017,46(6):807-809.
[14] 洪智峰,陈伟健,李明霞,等.可溶性髓样细胞触发受体1(sTREM-1)与可溶性血红蛋白清道夫受体(sCD163)在呼吸机相关性肺炎诊断中的临床意义[J].临床肺科杂志,2017,22(3):431-433.
[15] 陈少霖,张卫星,张 声,等.可溶性髓样细胞触发受体-1在呼吸机相关性肺炎的早期诊断及预后评估中的临床应用[J].中华医院感染学杂志,2017,27(13):2968-2971.
[16] 沈美珠,周 超,薛 菲,等.血清和呼出气冷凝液中可溶性髓系细胞触发受体-1检测有助于呼吸机相关性肺炎早期诊断及预后判断[J].国际呼吸杂志,2015,35(14):1041-1047.
[17] 文 兵,刘宇宇,明 波,等.血清降钙素原、CURB-65评分与CPIS评分及其联合诊断呼吸机相关肺炎的应用比较[J].实用医院临床杂志,2019,16(6):117-119.

相似文献/References:

[1]马明铭,李 芳,杨 慧,等.噻托溴胺粉雾剂联合非药物康复方案对慢性阻塞性肺疾病患者BODE指数的影响[J].陕西医学杂志,2019,(4):515.
　MA Mingming,LI Fang,YANG Hui,et al.Effect of tiotropium bromide powder and nonpharmacological rehabilitation program on BODE index in patients with chronic obstructive pulmonary disease[J].,2019,(12):515.
[2]朱小川.血小板/淋巴细胞比值预测慢性阻塞性肺疾病急性加重期〖JZ〗伴有早期肾功能损害临床价值[J].陕西医学杂志,2019,(10):1353.
　ZHU Xiaochuan..Clinical value of platelet/lymphocyte ratio in predicting early renal impairment〖JZ〗 in acute exacerbation of chronic obstructive pulmonary disease[J].,2019,(12):1353.
[3]张军营.吸烟对慢阻肺患者血清S100A8/A9、8异前列腺素F2α、组织蛋白酶S及其它炎症因子表达水平的影响*[J].陕西医学杂志,2019,(11):1426.
[4]焦文妤,尚家璐,李树霞△.慢性阻塞性肺疾病患者血清补体C1q肿瘤坏死因子相关蛋白5与肺功能及炎症反应相关性研究[J].陕西医学杂志,2019,(12):1616.
[5]陈辅萍.慢性阻塞性肺疾病并发感染性肺炎危险因素分析[J].陕西医学杂志,2020,49(1):102.
[6]薛佩妮,冯敏娟△,王惠琴.噻托溴铵粉联合糖皮质激素治疗慢性阻塞性肺疾病疗效及对患者生活质量评分的影响*[J].陕西医学杂志,2020,49(2):216.
　XUE Peini,FENG Minjuan,WANG Huiqin..Efficacy of tiotropium bromide combined with glucocorticoids in the treatment of COPD and its effect on patients' quality of life score[J].,2020,49(12):216.
[7]杨晓英,顾华杰,戴晓勇,等.重症超声在脓毒症机械通气患者撤机中的评估价值*[J].陕西医学杂志,2020,49(9):1094.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.010]
　YANG Xiaoying,GU Huajie,DAI Xiaoyong,et al.Evaluation value of severe ultrasound in weaning of sepsis patients with mechanical ventilation[J].,2020,49(12):1094.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.010]
[8]张卓红,赵拖利.慢性阻塞性肺疾病大鼠血液、支气管灌洗液中水通道蛋白及p-c-Jun-N-末端激酶表达情况实验研究[J].陕西医学杂志,2021,50(7):776.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.002]
　ZHANG Zhuohong,ZHAO Tuoli.Expression of AQP-1 and p-JNK in blood and bronchial lavage fluid of rats with COPD[J].,2021,50(12):776.[doi:DOI:10.3969/j.issn.1000-7377.2021.07.002]
[9]余 刚,张飔雪.慢性阻塞性肺疾病急性加重期患者血清干扰素-γ、甲壳质酶蛋白-40水平及与预后、肺功能相关性分析[J].陕西医学杂志,2021,50(10):1223.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.011]
　YU Gang,ZHANG Sixue.The levels of INF-γ and YKL-40 in patients with AECOPD and their correlation with prognosis and lung function[J].,2021,50(12):1223.[doi:DOI:10.3969/j.issn.1000-7377.2021.10.011]
[10]曾德优,张六一,肖 创,等.慢性阻塞性肺疾病动物模型研究进展[J].陕西医学杂志,2022,51(4):507.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.029]
　ZENG Deyou,ZHANG Liuyi,XIAO Chuang,et al.Research progress on animal models of chronic obstructive pulmonary disease[J].,2022,51(12):507.[doi:DOI:10.3969/j.issn.1000-7377.2022.04.029]

更新日期/Last Update: 2020-12-11