[1]梁 影,石秀芳.血管内皮生长因子和脂蛋白相关磷脂酶A2在脑梗死合并2型糖尿病患者中的表达及意义[J].陕西医学杂志,2020,49(12):1620-1623.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.021]
　LIANG Ying,SHI Xiufang..Expression and significance of VEGF and Lp-PLA2 in patients with type 2 diabetes mellitus complicated with cerebral infarction[J].,2020,49(12):1620-1623.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.021]
点击复制

血管内皮生长因子和脂蛋白相关磷脂酶A2在脑梗死合并2型糖尿病患者中的表达及意义
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年12期
页码:
1620-1623
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Expression and significance of VEGF and Lp-PLA2 in patients with type 2 diabetes mellitus complicated with cerebral infarction
作者:
梁 影; 石秀芳
安徽省亳州市人民医院(亳州 236803)
Author(s):
LIANG Ying; SHI Xiufang.
Bozhou People's Hospital,Anhui Province(Bozhou 236803)
关键词:
脑梗死;  2型糖尿病;  血管内皮生长因子;  脂蛋白相关磷脂酶A2
Keywords:
Cerebral infarction;  Type 2 diabetes mellitus;  Vascular endothelial growth factor;  Lipoprotein associated phospholipase A2
分类号:
R743.3
DOI:
DOI:10.3969/j.issn.1000-7377.2020.12.021
文献标志码:
A
摘要:
目的:探讨外周血血清血管内皮生长因子(VEGF)和脂蛋白相关磷脂酶A2(Lp-PLA2)在合并有2型糖尿病(T2DM)的脑梗死患者中的表达及临床意义。方法:选取脑梗死患者145例,其中伴T2DM者为研究组(79例),无T2DM者为参照组(66例)。选择同期因高血压、糖尿病或短暂性脑缺血发作就诊患者35例为对照组。入院12 h内均采集静脉血进行VEGF、Lp-PLA2水平的定量检测。结果:研究组血清VEGF、Lp-PLA2水平高于对照组,低于参照组,三组间两两比较差异有统计学意义(P<0.05)。ROC曲线分析显示,参照组血清VEGF和Lp-PLA2的曲线下面积分别为0.761、0.796,研究组的曲线下面积分别为0.571、0.663。结论:伴有T2DM脑梗死患者VEGF和Lp-PLA2表达水平的异常变化可能导致了T2DM患者发生脑梗死后病情重、预后差。
Abstract:
Objective:To investigate the expression and clinical significance of vascular endothelial growth factor(VEGF)and lipoprotein associated phospholipase A2(Lp-PLA2)in cerebral infarction patients with type 2 diabetes mellitus(T2DM).Methods:145 patients with cerebral infarction were selected,of which 79 patients with T2DM were selected as study group,and 66 patients without T2DM were selected as reference group.35 patients with hypertension,diabetes mellitus or transient ischemic attack were selected as control group during the same period.Venous blood samples were collected within 12 hours after admission for quantitative detection of VEGF and Lp-PLA2 levels.Results:The levels of VEGF and Lp-PLA2 in the study group were higher than those in the control group and lower than those in the reference group.There was significant difference between the three groups(P<0.05).ROC curve analysis showed that the areas under the curve of serum VEGF and Lp-PLA2 in the reference group were 0.761 and 0.796 respectively,and those in the study group were 0.571 and 0.663 respectively.Conclusion:The abnormal changes of VEGF and Lp-PLA2 expression levels may lead to severe illness and poor prognosis in patients with T2DM after cerebral infarction.

参考文献/References:

[1] 巫小燕,叶程程,杨 宏,等.2型糖尿病合并腔隙性脑梗死患者血清高迁移率族蛋白B1水平及其相关因素分析[J].中华全科医学,2018,16(8):1275-1278.
[2] 王成凯,宋 韵,张阿宁,等.铜川市2型糖尿病患者脑干梗死的危险因素分析[J].中国急救复苏与灾害医学杂志,2019,14(8):752-755.
[3] Bellicha A,Ciangura C,Poitou C,et al.Effectiveness of exercise training after bariatric surgery-a systematic literature review and meta-analysis[J].Obes Rev,2018,19(11):1544-1556.
[4] Khatami F,Mohajeri-Tehrani MR,Tavangar SM.The importance of precision medicine in type 2 diabetes mellitus(T2DM):from pharmacogenetic and pharmacoepigenetic aspects[J].Endocr Metab Immune Disord Drug Targets,2019,19(6):719-731.
[5] Long Y,Zhan Q,Yuan M,et al.The expression of microRNA-223 and FAM5C in cerebral infarction patients with diabetes mellitus[J].Cardiovasc Toxicol,2017,17(1):42-48.
[6] 潘之光,邱梅红,陈献华,等.损伤脑内神经血管网络重构的细胞和分子机制的研究[J].中国药理学与毒理学杂志,2018,32(9):674-675.
[7] 蒋月丽,解龙昌,梁 冬,等.Lp-PLA2、TNF-α及CRP在急性缺血性脑卒中患者中的表达及意义[J].西部医学,2019,31(11):1709-1714.
[8] 朱火兰,梁 磊,朱舜明,等.Lp-PLA2与急性冠脉综合征患者冠心病严重程度相关性的研究[J].陕西医学杂志,2016,45(12):1583-1585.
[9] 夏 慧,张新江.炎性因子与脑梗死预后相关性的研究进展[J].国际感染病学:电子版,2019,8(3):235-236.
[10] Eren F,Ksüz S,Küükodaci Z,et al.Targeted mesenchymal stem cell and vascular endothelial growth factor strategies for repair of nerve defects with nerve tissue implanted autogenous vein graft conduits[J].Microsurgery,2016,36(7):578-585.
[11] 郭连峰,牟 娜,刘兆玮,等.老年急性脑梗死患者血清CRP、VEGF及YKL-40水平动态变化及相关性[J].中国老年学杂志,2020,40(1):14-19.
[12] 刘晓东,秦海东,沈 华,等.不同程度急性脑梗死患者血清脂蛋白相关磷脂酶A2和超敏C反应蛋白水平及临床意义[J].陕西医学杂志,2016,45(9):1138-1139.
[13] 费云瀚,刘 斌,董亚楠,等.血管生成相关分子标记物与急性脑梗死患者颈动脉颅外段狭窄相关性研究[J].陕西医学杂志,2019,48(4):427-431.
[14] 王 瑞,苏显明,张秋萍.脂蛋白相关磷脂酶A2、同型半胱氨酸和D-二聚体与原发性高血压相关性分析[J].陕西医学杂志,2017,46(3):333-335.
[15] Maiolino G,Bisogni V,Rossitto G,et al.Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications[J].World J Cardiol,2015,7(10):609-620.
[16] 朱火兰,杜 洁,潘 硕,等.急性冠脉综合征患者GRACE评分与氯吡格雷抵抗相关性分析[J].陕西医学杂志,2017,46(10):1412-1414.
[17] 朱红云,鞠海兵,王 爽,等.糖尿病视网膜病变患者血清脂蛋白相关磷脂酶A2水平变化及其相关因素分析[J].中国糖尿病杂志,2017,25(8):707-710.

相似文献/References:

[1]杨文海,宁显忠,赵德福,等.脑梗死患者血清五聚素3、甲壳质酶蛋白40和白细胞分化抗原36表达及检测临床意义*[J].陕西医学杂志,2019,(3):301.
　YANG Wenhai,NING Xianzhong,ZHAO Defu,et al.Expressions and relationship of PTX3, YKL40 and CD36in patients with cerebral infarction[J].,2019,(12):301.
[2]费云瀚,刘 斌△,董亚楠,等.血管生成相关分子标记物与急性脑梗死患者颈动脉颅外段狭窄相关性研究*[J].陕西医学杂志,2019,(4):427.
　FEI Yunhan,LIU Bin,DONG Yanan,et al.Relevance study between angiogenesisrelated molecular markers and carotid artery extracranial stenosis in acute cerebral infarction patients[J].,2019,(12):427.
[3]李顺钧,王 慧,浦苏颖,等.急性脑梗死患者血清oxLDL、Hcy、LDL水平变化及检测临床意义[J].陕西医学杂志,2019,(5):664.
　LI Shunjun,WANG Hui,PU Suying,et al.Changes of oxLDL，Hcy and LDL levels in patients withcerebral infarction and their clinical significance[J].,2019,(12):664.
[4]贺龙梅,王 禺,王 凌,等.血清同型半胱氨酸、血浆纤维蛋白原与尿微量白蛋白联合检测预测脑梗死风险评估临床研究*[J].陕西医学杂志,2019,(7):903.
[5]卫晓红,宋艳玲△.血浆同型半胱氨酸、C反应蛋白和低密度脂蛋白胆固醇水平与〖JZ〗脑梗死患者颅内动脉、颅外动脉狭窄相关性分析[J].陕西医学杂志,2019,(10):1366.
[6]戴雨濛,张薇薇,孙梦雯△.中老年2型糖尿病患者尿白蛋白/肌酐与认知功能障碍相关性研究[J].陕西医学杂志,2020,49(3):325.
　DAI Yumeng,ZHANG Weiwei,SUN Mengwen..Correlation between urine albumin-creatinine ratio and cognitive dysfunction in middle-aged and elderly patients with type 2 diabetes mellitus[J].,2020,49(12):325.
[7]杨亚锋,王 萍△,王 利,等.2型糖尿病合并腹型肥胖男性患者胰岛素抵抗与内脏脂肪面积相关性研究*[J].陕西医学杂志,2020,49(6):717.[doi:DOI:10.3969/j.issn.10007377.2020.06.019]
[8]贺东红,黄亮星△.大动脉粥样硬化性前循环脑梗死患者临床特征及预后影响因素分析*[J].陕西医学杂志,2020,49(7):800.[doi:DOI:10.3969/j.issn.10007377.2020.07.008]
　HE Donghong,HUANG Liangxing..Clinical characteristics and prognostic factors of patients with atherosclerotic anterior circulation cerebral infarction[J].,2020,49(12):800.[doi:DOI:10.3969/j.issn.10007377.2020.07.008]
[9]常 翔,杨 琳,李 敏△.脑梗死患者血清炎症因子变化及其与颈动脉斑块稳定性、神经功能缺损程度的关系研究*[J].陕西医学杂志,2020,49(10):1253.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.013]
[10]张 玲,郭利军△.氢氯吡格雷与替格瑞洛在急性ST段抬高型心肌梗死合并2型糖尿病患者经皮冠状动脉介入治疗中的效果观察[J].陕西医学杂志,2020,49(10):1339.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.037]
　ZHANG Ling,GUO Lijun..Efficacy of hydroclopidogrel and ticagrelor in PCI in patients with acute ST-segment elevation myocardial infarction and type 2 diabetes mellitus[J].,2020,49(12):1339.[doi:DOI:10.3969/j.issn.1000-7377.2020.10.037]

更新日期/Last Update: 2020-12-11