[1]季福庆,付思佳,赵 娅,等.乳管扩张冲洗配合手法乳腺疏通治疗急性哺乳期乳腺炎疗效及对患者炎症因子的影响*[J].陕西医学杂志,2020,49(12):1612-1615.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.019]
　JI Fuqing,FU Sijia,ZHAO Ya,et al.Efficacy of breast duct dilation and irrigation combined with manipulation breast dredging in treatment of acute lactation mastitis and its influence on inflammatory factors of patients[J].,2020,49(12):1612-1615.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.019]
点击复制

乳管扩张冲洗配合手法乳腺疏通治疗急性哺乳期乳腺炎疗效及对患者炎症因子的影响*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年12期
页码:
1612-1615
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Efficacy of breast duct dilation and irrigation combined with manipulation breast dredging in treatment of acute lactation mastitis and its influence on inflammatory factors of patients
作者:
季福庆; 付思佳; 赵 娅; 吕勇刚△
西北大学附属医院(西安市第三医院)甲乳外科(西安 710018)
Author(s):
JI Fuqing; FU Sijia; ZHAO Ya; et al.
Department of Thyroid and Breast Surgery,Affiliated Hospital of Northwest University(Xi'an No.3 Hospital)(Xi'an 710018)
关键词:
乳管扩张冲洗;  乳腺疏通;  急性乳腺炎;  哺乳期;  症状;  炎症因子
Keywords:
Breast duct dilation and irrigation;  Breast dredging;  Acute mastitis;  Lactation;  Symptom;  Inflammatory factor
分类号:
R655.8
DOI:
DOI:10.3969/j.issn.1000-7377.2020.12.019
文献标志码:
A
摘要:
目的:观察乳管扩张冲洗配合手法乳腺疏通治疗急性哺乳期乳腺炎疗效及对患者炎症因子的影响。方法:将108例急性哺乳期乳腺炎患者随机分为观察组与对照组,各54例。对照组患者给予常规抗菌药物口服、传统人工排乳及吸奶器排乳治疗。观察组患者给予常规口服抗生素、乳管扩张冲洗配合手法乳腺疏通及吸奶器排乳治疗。比较两组临床疗效及症状、体征消退时间,治疗前与治疗3 d后血常规[白细胞计数(WBC)、红细胞沉降率(ESR)、中性粒细胞百分比(NE%)]、炎症因子[白细胞介素-8(IL-8)、降钙素原(PCT)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平变化。结果:观察组临床总有效率为92.59%,对照组为77.78%,组间比较有统计学差异(P<0.05)。观察组皮肤发红消退、肿块消退、疼痛消退、血象恢复、体温恢复的时间均显著短于对照组(P<0.05)。治疗3 d后,两组患者WBC、ESR、NE%、IL-8、PCT、IL-6、TNF-α、CRP水平与治疗前同组内比较有统计学差异(P<0.05),且治疗后组间比较有统计学差异(P<0.05)。结论:给予急性哺乳期乳腺炎患者乳管扩张冲洗配合手法乳腺疏通治疗可有效缓解其临床症状、体征,提高疗效,作用机制可能与促进炎症因子的降低及血常规指标的恢复有关。
Abstract:
Objective:To observe the efficacy of breast duct dilation and irrigation combined with manipulation breast dredging in treatment of acute lactation mastitis and its influence on inflammatory factors of patients.Methods:A total of 108 patients with acute lactation mastitis were randomly divided into observation group and control group,with 54 cases in each group.The control group was treated with conventional antibacterial drugs orally,traditional artificial milk ejection and breast pump for milk ejection,and the observation group was treated with conventional antibacterial drugs orally,breast duct dilation and irrigation combined with manipulation breast dredging and breast pump for milk ejection.The clinical efficacy,subsidence time of symptoms and signs,the blood routine [white blood cell count(WBC),erythrocyte sedimentation rate(ESR),neutrophil percentage(NE%)] and inflammatory factors [interleukin-8(IL-8),procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C reactive protein(CRP)] before and after 3 days of treatment were compared between the two groups.Results:The total clinical effective rate was 92.59% in observation group and 77.78% in control group,and there was statistical difference between the two groups(P<0.05).The time of skin redness regression,mass regression,pain regression,blood picture recovery and body temperature recovery in observation group were significantly shorter than those in the control group(P<0.05).After 3 days of treatment,there were statistically significant differences in the levels of WBC,ESR,NE%,IL-8,PCT,IL-6,TNF-α and CRP in the two groups compared with those before treatment(all P<0.05),and there were statistically significant differences between the two groups(P<0.05).Conclusion:Breast duct dilation and irrigation combined with manipulation breast dredging in the treatment of patients with acute lactation mastitis can effectively relieve the clinical symptoms and signs and enhance the efficacy.The mechanism may be related to promoting the decreases of inflammatory factors and the recovery of blood routine indicators.

参考文献/References:

[1] Bargi A,Hamali H,Nofouzi K,et al.Effect of intravenous infusion of hypertonic saline on treatment of the cows with acute E.Coli mastitis[J].Animal Behaviour,2015,4(2):273-283.
[2] Shinozuka Y,Kaneko S,Kurose T,et al.Factors associated with marketable milk production recovery after treatment of naturally occurring acute coliform mastitis[J].Journal of Veterinary Medical Science,2016,78(5):917-920.
[3] 贾 巍,张红真,王文娟,等.乳管镜联合超声检查诊断乳管内病变的价值研究[J].中国全科医学,2017,20(36):4557-4559.
[4] 李乃卿.西医外科学[M].北京:中国中医药出版社,2008:507-510.
[5] 林 毅,唐汉钧.现代中医乳房病学[M].北京:人民卫生出版社,2003:236-328.
[6] Shimamori T,Noda J,Tsukano K,et al.Particle-induced X-ray emission analysis of serum trace and major elements in cattle with acute coliform mastitis[J].Japanese Journal of Veterinary Research,2017,65(1):29-37.
[7] 黄 卉,李咏梅.柴胡疏肝散配合推拿手法治疗哺乳期急性乳腺炎临床观察[J].湖北中医药大学学报,2019,21(5):67-69.
[8] 田 甜,代幽静,张淑华,等.乳管扩张冲洗联合乳腺疏通在治疗急性哺乳期乳腺炎中的应用[J].临床与病理杂志,2018,38(12):2627-2631.
[9] 杨 进,荔 琦,常春峰.早期量化功能锻炼对髋关节骨折患者血液流变功能及炎症因子的影响[J].血栓与止血学,2020,26(2):250-251,254.
[10] 王荣华,高 峰,刘玉堂,等.纤维乳管镜在哺乳期积乳症早期应用的疗效观察[J].山西医药杂志,2018,47(24):2992-2993.
[11] 张腾华.乳管镜在哺乳期乳汁淤积性乳腺炎中的治疗作用[J].中华内分泌外科杂志,2015,9(5):409-410.
[12] 季东平,郭惠玲.哺乳期急性乳腺炎不同阶段的最佳治疗方法及四级预防的探讨分析[J].中国妇幼保健,2015,30(14):2179-2181.
[13] 刘 洁,王 斐,杨 侠,等.黄连解毒汤对重度颅脑损伤合并肺部感染患者血气指标和炎症因子影响分析[J].陕西中医,2020,41(3):318-320,349.
[14] 孙 雯,万 华.急性乳腺炎患者乳汁中微生物致病性研究进展[J].中国妇幼保健,2017,32(4):873-876.
[15] 孟军鹏,孟 林.颈动脉支架植入术对症状性颈动脉狭窄患者血清炎症因子及认知功能影响的临床研究[J].陕西医学杂志,2020,49(7):796-799.

备注/Memo

备注/Memo:
*西安市卫生健康委员会卫生科研人才项目(J201902045)
更新日期/Last Update: 2020-12-11