[1]王延磊,王政华△.CT引导下125I粒子植入联合吉西他滨、卡培他滨治疗局部进展期胰腺癌临床疗效观察*[J].陕西医学杂志,2020,49(12):1604-1607.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.017]
　WANG Yanlei,WANG Zhenghua..Clinical efficacy of CT-guided 125I particle implantation combined with gemcitabine and capecitabine in treatment of locally advanced pancreatic cancer[J].,2020,49(12):1604-1607.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.017]
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CT引导下125I粒子植入联合吉西他滨、卡培他滨治疗局部进展期胰腺癌临床疗效观察*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年12期
页码:
1604-1607
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Clinical efficacy of CT-guided 125I particle implantation combined with gemcitabine and capecitabine in treatment of locally advanced pancreatic cancer
作者:
王延磊; 王政华△
锦州医科大学附属第一医院肿瘤内科(锦州 121001)
Author(s):
WANG Yanlei; WANG Zhenghua.
Department of Oncology,the First Affiliated Hospital of Jinzhou Medical University(Jinzhou 121001)
关键词:
胰腺癌;  125I放射性粒子;  GEMCAP化疗;  临床疗效;  不良反应
Keywords:
Pancreatic cancer;  Radioactive 125I;  GEMCAP chemotherapy;  Clinical efficacy;  Adverse reaction
分类号:
R735.9
DOI:
DOI:10.3969/j.issn.1000-7377.2020.12.017
文献标志码:
A
摘要:
目的:观察CT引导下125I粒子组织间植入联合吉西他滨、卡培他滨(GEMCAP)治疗局部进展期胰腺癌的临床疗效。方法:选取局部进展期胰腺癌患者43例并分为观察组(22例)和对照组(21例)。观察组在CT引导下行放射性125I粒子组织间植入治疗后采用GEMCAP方案化疗,对照组仅行GEMCAP方案化疗,对比两组有效率、临床受益率、不良反应和生存率。结果:观察组客观缓解率和疾病控制率均高于对照组(P<0.05)。观察组临床受益率明显高于对照组(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。观察组中位无进展生存期(PFS)及中位总生存期(OS)均高于对照组(P<0.05)。结论:125I粒子组织间植入联合GEMCAP化疗治疗局部进展期胰腺癌,可有效控制肿瘤进展,在提高晚期患者生存质量的基础上能有效延长胰腺癌患者生存期。
Abstract:
Objective:To observe the clinical efficacy of CT-guided125I particle interstitial implantation combined with gemcitabine and capecitabine(GEMCAP)in the treatment of locally advanced pancreatic cancer.Methods:43 patients with locally advanced pancreatic cancer were selected and divided into observation group(22 cases)and control group(21 cases).125I particle interstitial implantation combined with GEMCAP chemotherapy was performed in observation group,and the control group only received GEMCAP chemotherapy.The effective rate,clinical benefit rate,adverse reactions and survival rate of the two groups were compared.Results:The objective remission rate and disease control rate of the observation group were higher than those of the control group(P<0.05).The clinical benefit rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).PFS and OS of the observation group were higher than those of the control group(P<0.05).Conclusion:In the treatment of locally advanced pancreatic cancer, 125I particle interstitial implantation combined with GEMCAP chemotherapy can effectively control the tumor progression and prolong the survival time of patients on the basis of improving the quality of life of patients with advanced pancreatic cancer.

参考文献/References:

[1] 王俊杰,唐劲天,黎 功.放射性粒子近距离治疗肿瘤[M].北京:北京医科大学出版社,2001:200.
[2] Liu Y,Cheng Y.Reaserch on response evaluation criteria in solid tumor[J].Pract Oncol J,2004,18(2):149-152.
[3] Heinemann V.Gemecitabine-based combination treatment of pancreatic cancer[J].Semin Oncol,2002,29(Suppl 3):25.
[4] 马 鹏,孟存英,马 莹,等.碘-125放射性粒子支架治疗中晚期食管癌疗效观察[J].陕西医学杂志,2015,44(11):1481-1483.
[5] Zhou JC.Practical medical oncology[M].Beijing:People's Medical Publishing House,2003:45-46.
[6] Burris HA,Moore MJ,Andersen J,et al.Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer:a randomized trial[J].J Clin Oncol,1997,15(6):2403.
[7] Wang SK,Zhang AY,Zhang WH,et al.Progress of radioactive seed implantation in the treatment of tumor[J].BMU Journal,2007,30(2):124-126.
[8] 张 颖,林 琦,袁 苑,等.3D打印个体化模板联合CT引导125I粒子植入治疗胸壁转移瘤1例[J].山东大学学报:医学版,2016,4(56):94-96.
[9] 郭延玲,胡彦辉.清胰化积方联合顺铂治疗胰腺癌疗效及对TGF-β/smads信号通路的影响[J].陕西中医,2018,39(9):1210-1213.
[10] Parashar B,Arora S,Wernicke AG.Radiation therapy for early stage lung cancer[J].Semin Intervent Radiol,2013,30(2):185-190.
[11] 宋亚邛,胡海燕.VEGF、TGF-β1、CA19-9、CA242和DKK1联合检测对早期胰腺癌临床诊断价值研究[J].陕西医学杂志,2020,49(2):237-240.
[12] Yang M,Fang Z,Yan Z,et al.Transarterial chemoembolisation(TACE)combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis versus TACE alone:a two-arm,randomized clinical trial[J].J Cancer Res Clin Oncol,2014,140(2):211-219.
[13] Marcu LG,Lawson JM.Technical and dosimetric aspects of iodine-125 seed reimplantation in suboptimal prostate implants[J].Br J Radiol,2013,86(1026):20130058.
[14] Keyes M,Morris WJ,Spadinger I,et al.Radiation oncology and medical physicists quality assurance in british columbia cancer agency provincial prostate brachytherapy program[J].Brachy Therapy,2013,12(4):343-355.
[15] 宁 峥,李宏宇,郭晓钟,等.I-125粒子植入联合化疗和单纯化疗对胰腺癌疗效的荟萃分析[J].胃肠病学和肝病学杂志,2016,25(3):320.
[16] Yoshitomi H,Togawa A,Kimura F,et al.A randomized phase Ⅱ trial of adjuvant chemotherapy with uraci/tegafur and gemcitabine versus gemcitabine alone in patients with resected pancreatic cancer[J].Cancer,2008,113(9):2448-2456.

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备注/Memo

备注/Memo:
*内蒙古自治区自然科学基金资助面上项目(2013MS1176)
更新日期/Last Update: 2020-12-11