[1]石 敏,邹 健,李乔岳,等.2型糖尿病患者糖化白蛋白和糖化血红蛋白比值与周围神经病变相关性研究*[J].陕西医学杂志,2020,49(12):1557-1560.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.005]
　SHI Min,ZOU Jian,LI Qiaoyue,et al.Association between GA/HbA1c ratio and diabetic peripheral neuropathy in patients with type 2 diabetes[J].,2020,49(12):1557-1560.[doi:DOI:10.3969/j.issn.1000-7377.2020.12.005]
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2型糖尿病患者糖化白蛋白和糖化血红蛋白比值与周围神经病变相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年12期
页码:
1557-1560
栏目:
临床研究
出版日期:
2020-12-05

文章信息/Info

Title:
Association between GA/HbA1c ratio and diabetic peripheral neuropathy in patients with type 2 diabetes
作者:
石 敏1; 邹 健2; 李乔岳1; 赵国霞1; 张娜娜1; 王 琼1; 李晓苗1△
1.空军军医大学西京医院(西安 710032); 2.解放军第522医院(洛阳 471000)
Author(s):
SHI Min; ZOU Jian; LI Qiaoyue; et al.
Xijing Hospital,Air Force Medical University(Xi'an 710032)
关键词:
2型糖尿病;  糖化白蛋白;  糖化血红蛋白;  糖尿病周围神经病变;  糖尿病微血管并发症;  血糖波动
Keywords:
Type 2 diabetes;  Glycated albumin;  Glycated hemoglobin;  Diabetic peripheral neuropathy;  Diabetic microvascular complication;  Glycemic variability
分类号:
R587.2
DOI:
DOI:10.3969/j.issn.1000-7377.2020.12.005
文献标志码:
A
摘要:
目的:探讨2型糖尿病(T2DM)患者糖化白蛋白(GA)和糖化血红蛋白(HbA1c)比值(GA/HbA1c)与糖尿病周围神经病变(DPN)的相关性。方法:选取2型糖尿病住院患者233例,根据神经传导功能检查(NCS)结果分为DPN组和非DPN组。比较两组患者一般资料和生化指标的差异。采用Logistic回归分析GA/HbA1c比值与DPN的相关性。结果:在纳入研究的233例患者中,113例患有DPN,患病率为48.5%。DPN组患者的年龄、糖尿病病程、空腹血糖(FBG)、GA、HbA1c、GA/HbA1c比值均高于非DPN组(P<0.05),而血红蛋白(HGB)和白蛋白(ALB)均低于非DPN组(P<0.05)。DPN患病率随GA/HbA1c比值的升高而升高。Logistic回归分析结果显示,与低GA/HbA1c比值(1.41～2.46)的患者相比,GA/HbA1c比值高(2.82～4.07)的患者DPN发生率更高(P<0.05)。结论:糖化白蛋白和糖化血红蛋白比值是T2DM患者DPN发生的危险因素。
Abstract:
Objective:To investigate the association between the glycated albumin(GA)to glycated hemoglobin(HbA1c)(GA/HbA1c)ratio and diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes.Methods:A total of 233 inpatients with type 2 diabetes were enrolled and classified into 2 groups according to nerve conduction study:DPN group and non-DPN group.The general data and biochemical indicators were compared between the two groups.Logistic regression analysis was used to study the association between GA/HbA1c ratio and DPN.Results:Of the 233 patients,113(48.5%)suffered from DPN.The age,duration of diabetes,FBG,GA,HbA1c and GA/HbA1c ratio in the DPN group were significantly higher than those in the non-DPN group,while hemoglobin(HGB)and albumin(ALB)were lower than those in the non-DPN group(P<0.05). DPN prevalence increased with GA/HbA1c ratio.Logistic regression analysis showed that,patients with high GA/HbA1c ratio(2.82-4.07)had a higher incidence of DPN compared with patients with low GA/HbA1c ratio(1.41-2.46)(P<0.05).Conclusion:The GA/HbA1c ratio is a risk factor for diabetic peripheral neuropathy in patients with type 2 diabetes.

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备注/Memo

备注/Memo:
*国家自然科学基金资助面上项目(81573746)
更新日期/Last Update: 2020-12-11