[1]李春梦,王海峰,卢 佩,等.糖尿病肾病患者D-二聚体、纤维蛋白原、胱抑素C检测及临床意义*[J].陕西医学杂志,2020,49(11):1503-1506.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.035]
　LI Chunmeng,WANG Haifeng,LU Pei,et al.Detection and clinical significance of D-dimer,fibrinogen,cystatin C in patients with diabetic nephropathy[J].,2020,49(11):1503-1506.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.035]
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糖尿病肾病患者D-二聚体、纤维蛋白原、胱抑素C检测及临床意义*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年11期
页码:
1503-1506
栏目:
临床检验
出版日期:
2020-11-05

文章信息/Info

Title:
Detection and clinical significance of D-dimer,fibrinogen,cystatin C in patients with diabetic nephropathy
作者:
李春梦1; 王海峰2;  卢 佩3; 朱兵兵3; 刘海波1△
1.陕西省中医医院(西安 710003); 2.武警陕西省总队医院(西安 710054); 3.空军军医大学西京医院检验科(西安 710032)
Author(s):
LI Chunmeng; WANG Haifeng; LU Pei; et al.
Shaanxi Provincial Hospital of Traditional Chinese Medicine(Xi'an 710003)
关键词:
D-二聚体;  胱抑素C;  纤维蛋白原;  糖化血红蛋白;  糖尿病肾病;  肌酐
Keywords:
D-dimer;  Cystatin C;  Fibrinogen;  Glycosylated hemoglobin;  Diabetic nephropathy;  Creatinine
分类号:
R587.2
DOI:
DOI:10.3969/j.issn.1000-7377.2020.11.035
文献标志码:
A
摘要:
目的:探讨D-二聚体、纤维蛋白原、胱抑素C与糖尿病肾病的关联以及检测临床意义价值。方法:收集糖尿病肾病患者186例作为观察组,另外选择体检健康者100例作为对照组。对两组D-二聚体、纤维蛋白原、胱抑素C、甘油三酯、肌酐和糖化血红蛋白A1c进行检测,进行统计学分析。结果:糖尿病肾病患者D-二聚体、胱抑素C、纤维蛋白原、肌酐和糖化血红蛋白的水平均高于健康对照组(P0.05); 各期患者D-二聚体、胱抑素C、纤维蛋白原,多组间方差分析(F=4.453、4.183、71.440)差异有统计学意义(P<0.05); 甘油三酯和糖化血红蛋白多组间方差分析(F=1.179、1.034)差异无统计学意义(P>0.05); D-二聚体、胱抑素C、纤维蛋白原与肌酐水平均呈正相关,相关系数分别为0.469、0.323、0.869; 甘油三酯与肌酐水平无相关性。结论:D-二聚体、胱抑素C、纤维蛋白原能够作为糖尿病肾病发生发展的参考指标,对监测糖尿病肾病的发生与发展有一定意义。
Abstract:
Objective:To investigate the correlation between D-dimer,fibrinogen,cystatin C and diabetic nephropathy and the value in the study of the pathogenesis of diabetic nephropathy.Methods:186 patients with diabetic nephropathy were collected as the observation group,and 100 healthy patients were selected as the control group.The two groups of D-dimer,fibrinogen,cystatin C,triglycerides,creatinine and glycosylated hemoglobin A1c were detected and statistically analyzed.Results:The levels of D-dimer,fibrinogen,cystatin C,creatinine and glycosylated hemoglobin in observation group were higher than those in control group(P<0.05).There was no statistically significant difference in triglycerides between the two groups(P>0.05).D-dimer,fibrinogen and cystatin C in each group of patients with diabetic nephropathy were analyzed by anova,and the differences were statistically significant(F=4.453,4.183,71.440,P<0.05).Triglyceride and glycosylated hemoglobin in each group of patients with diabetic nephropathy were analyzed by anova,and the differences were not statistically significant(F=1.179,1.034,P>0.05).D-dimer,fibrinogen and cystatin C were positively correlated with creatinine level(r=0.469,0.323,0.869),but there was no correlation between triglycerides and creatinine levels.Conclusion:D-dimer,fibrinogen and cystatin C can be used as reference indexes for the occurrence and development of diabetic nephropathy,which has certain significance for monitoring the occurrence and development of diabetic nephropathy.

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备注/Memo

备注/Memo:
*西安市科技计划项目[201805103YX11SF37(15)]
更新日期/Last Update: 2020-11-05