[1]王俊姬,何 平,薛泽恩,等.血清脑源性神经营养因子、白细胞介素-8、肿瘤坏死因子-α、超氧化物歧化酶水平对新生儿缺氧缺血性脑病严重程度及预后的评估价值[J].陕西医学杂志,2020,49(11):1465-1468,1522.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.024]
　WANG Junji,HE Ping,XUE Ze'en,et al.Evaluation value of serum BDNF,IL-8,TNF-α and SOD levels for severity and prognosis of hypoxic-ischemic encephalopathy in neonates[J].,2020,49(11):1465-1468,1522.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.024]
点击复制

血清脑源性神经营养因子、白细胞介素-8、肿瘤坏死因子-α、超氧化物歧化酶水平对新生儿缺氧缺血性脑病严重程度及预后的评估价值
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年11期
页码:
1465-1468,1522
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
Evaluation value of serum BDNF,IL-8,TNF-α and SOD levels for severity and prognosis of hypoxic-ischemic encephalopathy in neonates
作者:
王俊姬1; 何 平1; 薛泽恩1; 乔 红1; 王文静2△
1.陕西中医药大学第二附属医院(咸阳712000); 2.西安交通大学医学院附属儿童医院(西安710003)
Author(s):
WANG Junji; HE Ping; XUE Ze'en; et al.
The Second Affiliated Hospital of Shaanxi University of Chinese Medicine(Xianyang 712000)
关键词:
新生儿缺氧缺血性脑病;  脑源性神经营养因子;  白介素-8;  肿瘤坏死因子-α;  超氧化物歧化酶;  相关性;  受试者工作特征曲线;  预后
Keywords:
Neonatal hypoxic-ischemic encephalopathy;  Brain-derived neurotrophic factor;  Interleukin-8;  Tumor necrosis factor-α;  Superoxide dismutase;  Correlation;  Receiver operating characteristic curve;  Prognosis
分类号:
R722.12
DOI:
DOI:10.3969/j.issn.1000-7377.2020.11.024
文献标志码:
A
摘要:
目的:探究血清脑源性神经营养因子(BDNF)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、超氧化物歧化酶(SOD)水平对新生儿缺氧缺血性脑病(HIE)严重程度及预后的评估价值。方法:回顾性分析68例HIE患儿的临床资料,根据病情严重程度将纳入患儿分为轻度组(n=27例)、中度组(n=23例)、重度组(n=18例),另选取同期50例健康新生儿作为正常对照组,均检测血清BDNF、IL-8、TNF-α、SOD水平,Spearman相关性分析血清BDNF、IL-8、TNF-α、SOD水平与HIE严重程度的关系,受试者工作特征曲线(ROC)分析血清BDNF、IL-8、TNF-α、SOD值单一或联合对HIE患儿预后的预测价值。结果:HIE组血清BDNF、SOD水平低于正常对照组(P<0.05),血清IL-8、TNF-α水平高于正常对照组(P<0.05); 随着HIE病情加重,患儿血清BDNF、SOD水平逐渐降低,血清IL-8、TNF-α水平逐渐上升,组间两两比较差异均有统计学意义(P<0.05); Spearman相关性分析显示HIE患儿血清BDNF、SOD水平与病情严重程度呈显著负相关关系(r=-0.621、-0.598,P<0.05),IL-8、TNF-α与病情严重程度呈显著正相关关系(r=0.562、0.663,P<0.05); ROC分析结果显示联合预测HIE患儿预后结局曲线下面积(AUC)0.955大于BDNF、IL-8、TNF-α、SOD值单一预测0.805、0.754、0.855、0.762(P<0.05)。结论:血清BDNF、IL-8、TNF-α、SOD水平可用于评估HIE严重程度,可有效预测患儿预后。
Abstract:
Objective:To explore the evaluation value of serum brain-derived neurotrophic factor(BDNF),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)and superoxide dismutase(SOD)levels for severity and prognosis of hypoxic-ischemic encephalopathy(HIE)in neonates.Methods:A retrospective analysis was performed on the clinical medical data of 68 HIE children.According to disease severity,they were divided into mild group(n=27),moderate group(n=23)and severe group(n=18).Another 50 healthy neonates during the same period were enrolled as normal control group.The levels of serum BDNF,IL-8,TNF-α and SOD were detected.Their relationship with HIE severity was analyzed by Spearman correlation analysis.The predictive value of serum BDNF,IL-8,TNF-α,SOD alone and their combination for prognosis of HIE neonates was analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum BDNF and SOD in HIE group were lower than those in normal control group(P<0.05),while the levels of serum IL-8 and TNF-α were higher than those in normal control group(P<0.05).As the exacerbation of HIE,the levels of serum BDNF and SOD were gradually decreased,while the levels of serum IL-8 and TNF-α were gradually increased,the differences between the groups were statistically significant(P<0.05).Spearman correlation analysis showed that the levels of serum BDNF and SOD were significantly negatively correlated with HIE severity(r=-0.621,-0.598,P<0.05),while the levels of IL-8 and TNF-α were significantly positively correlated with HIE severity(r=0.562,0.663,P<0.05).The analysis results of ROC curves showed that the area under the curve(AUC)of BDNF combined with IL-8,TNF-α and SOD for predicting prognosis of HIE children was 0.955,which was greater than that of single index(0.805,0.754,0.855,0.762)(P<0.05).Conclusion:The levels of serum BDNF,IL-8,TNF-α and SOD can be applied to assess HIE severity,which can effectively predict prognosis.

参考文献/References:

[1] 宋彩虹.头颅MRI检查对评价足月新生儿缺氧缺血性脑病严重程度价值探讨[J].陕西医学杂志,2017,46(3):348-350.
[2] Szakmar E,Jermendy A,Eldib M.Correction:Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy[J].Journal of Perinatology,2019,39(6):891-895.
[3] Marina A,Kiran T,Kathleen S,et al.Apgar scores at 10 minutes and outcomes in term and late preterm neonates with hypoxic-ischemic encephalopathy in the cooling era[J].American Journal of Perinatology,2018,36(5):545-554.
[4] 李熙鸿.我国新生儿缺氧缺血性脑病的诊断及治疗[J].实用儿科临床杂志,2010,25(14):1037-1039.
[5] 余旭东,杨文忠,欧阳伟,等.新生儿中、重度缺氧缺血性脑病的MRI评估分级价值[J].放射学实践,2016,31(2):175-178.
[6] 王秋丽,吕红艳,董志勇,等.中重度新生儿缺氧缺血性脑病患儿血清尿酸、Tau蛋白水平变化及其与窒息程度、神经发育预后的相关性研究[J].实用心脑肺血管病杂志,2019,27(12):47-52.
[7] 石计朋,栗延伟,桑桂梅,等.miRNA-21在新生儿缺氧缺血性脑病患儿血清中表达的意义[J].实用预防医学,2018,25(6):655-658.
[8] Ulrike H,Martina P,Erich S,et al.Plasma and serum brain-derived neurotrophic factor(BDNF)levels and their association with neurocognition in at-risk mental state,first episode psychosis and chronic schizophrenia patients[J].World Journal of Biological Psychiatry,2018,20(7):545-554.
[9] Hogarth SJ,Jaehne EJ,Maarten VD,et al.Brain-derived neurotrophic factor(BDNF)determines a sex difference in cue-conditioned alcohol seeking in rats[J].Behavioural Brain Research,2018,33(9):73-78.
[10] 牛佳媛,吴子怡,薛 杭,等.七氟醚后处理对缺血缺氧性脑损伤新生大鼠行为学及海马中BDNF表达的影响[J].中国医科大学学报,2019,48(10):870-873,886.
[11] 王 静,郑荣秀.BDNF修饰的骨髓间充质干细胞对缺氧缺血性脑损伤大鼠脑区BDNF/TrkB信号通路表达的影响与意义[J].中国妇幼保健,2019,34(7):1656-1659.
[12] 田培超,李建华,陈国洪.血清脑源性神经营养因子及酪氨酸激酶受体B与新生儿缺氧缺血性脑病的相关性研究[J].中华物理医学与康复杂志,2013,35(4):315-317.
[13] 韩传映,吴春芳,李艳阁.单唾液酸四己糖神经节苷脂治疗缺氧缺血性脑病的疗效及其对炎症因子的影响[J].安徽医学,2019,40(8):927-929.
[14] 果崇慧,杨 青.神经节苷脂治疗新生儿缺氧缺血性脑病对患儿血清炎症相关细胞因子和MMP-9的影响[J].河北医药,2018,40(2):219-223.
[15] 曾旦丹,赵迎春,朱莹莹,等.新生儿缺氧缺血性脑病血清UA、Cys C及TNF-α水平变化及与脑损伤的相关性研究[J].现代生物医学进展,2018,18(14):2665-2668.
[16] 张 蕾,贾秋平,黄长缨,等.新生儿缺氧缺血性脑病患儿血清IL-8、TNF-α、ICAM-1水平的表达及与新生儿神经行为评分的相关性[J].实用预防医学,2018,25(12):1476-1479.
[17] 徐 平,刘 洁.神经节苷脂联合家庭康复训练对HIE患儿神经损伤、神经发育及氧化应激的影响[J].海南医学院学报,2018,24(10):1019-1022.
[18] 骆书辉,张占华.亚低温联合EPO治疗对新生儿缺氧缺血性脑病脑损伤、心肌损伤及氧化应激的影响[J].海南医学院学报,2018,24(16):1517-1520.

相似文献/References:

[1]邓春颖,李海滨,毛文静,等.丁苯酞对阿尔茨海默病模型大鼠海马CA1 区脑源性神经营养因子和碱性成纤维生长因子蛋白表达影响的实验研究*[J].陕西医学杂志,2020,49(4):405.
　DENG Chunying,LI Haibin,MAO Wenjing,et al.Effect of dl-3-n-butylphthalide on the expression of BDNF and bFGF in CA1 region of hippocampus of Alzheimer disease rats[J].,2020,49(11):405.
[2]林 惠,颜 芬△.微小RNA-195-5p与脑源性神经营养因子在哮喘急性发作期患儿血清中表达相关性研究[J].陕西医学杂志,2020,49(7):862.[doi:DOI:10.3969/j.issn.10007377.2020.07.026]
　LIN Hui,YAN Fen..Expression of miR-195-5p and brain-derived neurotrophic factor in the serum of children with acute asthma attack and their correlation[J].,2020,49(11):862.[doi:DOI:10.3969/j.issn.10007377.2020.07.026]
[3]宋彩虹,张 瑜,杨学武,等.氢质子磁共振波谱联合Gesell发育量表对足月新生儿缺氧缺血性脑病预后的评估价值[J].陕西医学杂志,2021,50(3):323.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.017]
[4]刘源源.左乙拉西坦治疗成人癫痫疗效及对患者血清脑源性神经营养因子和miR-134-5p的影响[J].陕西医学杂志,2021,50(3):349.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.024]
　LIU Yuanyuan.Efficacy of levetiracetam in treatment of adult epilepsy and its effect on serum BDNF and miR-134-5p[J].,2021,50(11):349.[doi:DOI:10.3969/j.issn.1000-7377.2021.03.024]
[5]陈金权,王 蕊.右美托咪定对慢性心力衰竭大鼠的作用及机制研究[J].陕西医学杂志,2022,51(6):664.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.005]
　CHEN Jinquan,WANG Rui.Effect and mechanism of dexmedetomidine on chronic heart failure in rats[J].,2022,51(11):664.[doi:DOI:10.3969/j.issn.1000-7377.2022.06.005]
[6]周 平,蔡 敏,袁 平,等.马来酸氟伏沙明联合经颅直流电刺激对首发强迫症患者认知功能、焦虑症状及血清5-羟色胺、脑源性神经营养因子水平的影响[J].陕西医学杂志,2022,51(8):990.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.020]
　ZHOU Ping,CAI Min,YUAN Ping,et al.Effects of fluvoxamine combined with transcranial direct current stimulation on cognitive function,anxiety symptoms,serum BDNF and 5-HT levels in patients with first-episode obsessive-compulsive disorder[J].,2022,51(11):990.[doi:DOI:10.3969/j.issn.1000-7377.2022.08.020]
[7]袁 丹,徐思雨,甄伟兰,等.丁苯酞联合尼麦角林治疗血管性痴呆疗效及对患者血清神经视锥蛋白样蛋白1、脑源性神经营养因子水平的影响[J].陕西医学杂志,2023,52(9):1233.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.028]
　YUAN Dan,XU Siyu,ZHEN Weilan,et al.Efficacy of butylphthalide combined with nicergoline in treatment of vascular dementia and their influence on serum VILIP-1 and BDNF levels[J].,2023,52(11):1233.[doi:DOI:10.3969/j.issn.1000-7377.2023.09.028]
[8]赵翠党,赵红雷,史 炯,等.依托咪酯对视神经损伤成年大鼠视网膜神经节细胞的保护作用及对半胱氨酸天冬氨酸蛋白酶3、脑源性神经营养因子蛋白表达的影响[J].陕西医学杂志,2024,(7):905.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.008]
　ZHAO Cuidang,ZHAO Honglei,SHI Jiong,et al.Protective effect of etomidate on retinal ganglion cells and its effect on expression of Caspase-3 and brain-derived neurotrophic factor in adult rats with optic nerve injury[J].,2024,(11):905.[doi:DOI:10.3969/j.issn.1000-7377.2024.07.008]

更新日期/Last Update: 2020-11-05