[1]程永红,韩 梅△,贾晓斌,等.外周血白细胞分化抗原195、雌二醇水平与桥本甲状腺炎相关性研究*[J].陕西医学杂志,2020,49(11):1461-1464.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.023]
　CHENG Yonghong,HAN Mei,JIA Xiaobin,et al.Relationship between the levels of leukocyte differentiation antigen 195and estradiol in peripheral blood and Hashimoto thyroiditis[J].,2020,49(11):1461-1464.[doi:DOI:10.3969/j.issn.1000-7377.2020.11.023]
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外周血白细胞分化抗原195、雌二醇水平与桥本甲状腺炎相关性研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年11期
页码:
1461-1464
栏目:
临床研究
出版日期:
2020-11-05

文章信息/Info

Title:
Relationship between the levels of leukocyte differentiation antigen 195and estradiol in peripheral blood and Hashimoto thyroiditis
作者:
程永红1; 韩 梅2△; 贾晓斌1; 刘 苗1; 刘 懿3
1.陕西省商洛市中心医院(商洛726000); 2.陕西省咸阳市泾阳县医院检验科(咸阳713700); 3.西安交通大学第一附属医院检验科(西安710061)
Author(s):
CHENG Yonghong; HAN Mei; JIA Xiaobin; et al.
Shangluo Central Hospital,Shaanxi Province(Shangluo 726000)
关键词:
桥本甲状腺炎;  甲状腺功能减退;  峡部厚径;  雌二醇;  白细胞分化抗原195;  甲状腺过氧化物酶抗体
Keywords:
Hashimoto thyroiditis;  Hypothyroidism;  Isthmus thickness;  Estradiol;  Leukocyte differentiation antigen 195;  Thyroid peroxidase antibody
分类号:
R581.4
DOI:
DOI:10.3969/j.issn.1000-7377.2020.11.023
文献标志码:
A
摘要:
目的:探讨桥本甲状腺炎(HT)患者外周血雌二醇、白细胞分化抗原195(CD195)水平与桥本甲状腺炎的相关性。方法:选择80例女性HT患者作为研究对象,依据HT患者的甲功检查结果分为正常组(39例)和甲功减退组(甲减组,41例),另选36例同期体检健康者作为对照组。采用流式细胞仪分析两组CD195阳性细胞百分比、采用电化学发光法检测血清雌二醇水平、采用彩色超声诊断仪分析甲状腺峡部厚径。结果:甲减组和正常组的雌二醇水平和CD195阳性细胞百分比均高于对照组,其中甲减组的增高更显著(P<0.01)。相关性分析显示,甲减组和正常组的雌激素水平和CD195阳性细胞百分比有正相关性(r=0.823,P<0.01),甲减的雌激素水平和CD195阳性细胞百分比分别与促甲状腺激素(TSH),甲状腺过氧化物酶抗体(TPO-Ab)及峡部厚径有正相关性,而与游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平有负相关性[r(雌二醇)=0.838,0.810,0.817,-0.799,-0.803,均P<0.01; r(CD195)=0.824,0.809,0.782,-0.804,-0.829,均P<0.01]。正常组的雌激素水平和CD195阳性细胞百分比分别与TSH,TPO-Ab水平及峡部厚径有正相关性[r(雌二醇)=0.786,0.821,0.808,均P<0.01; r(CD195)=0.771,0.789,0.802,均P<0.01]。结论:雌二醇和CD195与HT的发生发展有关,外周血液雌二醇、CD195水平的异常变化可能诱导了HT的发生。
Abstract:
Objective:To investigate the relationship between the levels of leukocyte differentiation antigen 195(CD195)and estradiol in peripheral blood and Hashimoto thyroiditis(HT).Methods:80 female HT patients were selected and divided into normal group(39 cases)and hypothyroidism group(41 cases),and 36 healthy persons were selected as control group.The percentage of CD195 positive cells was analyzed by flow cytometry.The serum estradiol level was detected by electrochemiluminescence.The thickness of thyroid isthmus was analyzed by color Doppler ultrasound.Results:The estradiol level and the percentage of CD195 positive cells in hypothyroidism group and normal group were higher than those in control group,and the increase in the hypothyroidism group was more significant(P<0.01).Correlation analysis showed that there was a positive correlation between the estrogen level and the percentage of CD195 positive cells in hypothyroidism group and normal group(r=0.823,P<0.01).The estrogen level and the percentage of CD195 positive cells in hypothyroidism group were positively correlated with thyroid stimulating hormone(TSH),thyroid peroxidase antibody(TPO-Ab)and the thickness of thyroid isthmus,but were negatively correlated with triiodothyronine(FT3)and free thyroxine(FT4)levels [r(estradiol)=0.838,0.810,0.817,-0.799,-0.803,all P<0.01; r(CD195)=0.824,0.809,0.782,-0.804,-0.829,all P<0.01].The estrogen level and the percentage of CD195 positive cells in the normal group were positively correlated with TSH,TPO-Ab levels and the thickness of the isthmus [r(estradiol)=0.786,0.821,0.808,all P<0.01; r(CD195) =0.771,0.789,0.802,all P<0.01].Conclusion:Estradiol and CD195 are related to the occurrence and development of HT.The abnormal changes of the levels of estradiol and CD195 in peripheral blood may induce HT.

参考文献/References:

[1] 孙世怡,胡玉萍,田济铭,等.雌孕激素及其受体与甲状腺疾病关系的研究进展[J].大连医科大学学报,2018,40(4):364-367.
[2] 李 玉,罗 荔.祛瘀补肾方结合西药治疗桥本氏甲状腺炎的疗效及对患者免疫功能的影响[J].陕西中医,2016,37(10):1370-1371.
[3] Alberto L,Laura P,Marta C,et al.Rhabdomyolysis in a young girl with van wyk-grumbach syndrome due to severe hashimoto thyroiditis[J].Int J Environ Res Public Health,2018,15(4):704.
[4] Xiang H,Qiao Z,Feng G,et al.Premature ovarian failure,short stature,and hashimoto's disease in an 18-year-old adolescent girl with 46,X,i(X)(q10)[J].Gynecol Endocrinol,2018,34(11):925-927.
[5] 茹 平,黄 刚.桥本甲状腺炎患者外周血液MCP-1和CD195水平检测的临床意义及相关性研究[J].现代检验医学杂志,2020,35(1):86-89.
[6] Gunay M,Celik G,Yildiz E,et al.Ocular surface evaluation in pediatric Hashimoto's thyroiditis without thyroid-associated ophthalmopathy[J].Arq Bras Oftalmol,2019,82(4):283-288.
[7] 王 斐,张缓媛,李 鹏,等.桥本甲状腺炎与ABO血型的相关性[J].中华全科医学,2015,13(7):1068-1070,1113.
[8] Zhangbi W,Yaojun C,Qin XI,et al.Hashimoto's thyroiditis impairs embryo implantation by compromising endometrial morphology and receptivity markers in euthyroid mice[J].Reproductive Biology and Endocrinology,2019,17:94.
[9] 肖新怀.香远合剂对桥本氏甲状腺炎大鼠Th1/Th2细胞平衡的影响及意义[J].中国免疫学杂志,2019,35(20):2446-2451.
[10] 袁晓岚,汪琳姣,王 为,等.内脂素、CD195、CD30及RORα水平与桥本甲状腺炎甲状腺功能减低的相关性分析[J].国际检验医学杂志,2019,40(6):764-768.
[11] 聂 莉,吴 薇.血清Hcy表达评估桥本氏甲状腺炎合并冠心病患者突发心绞痛的临床意义[J].标记免疫分析与临床,2017,24(5):545-549.
[12] 李存杰,雷 婷.复方黄芪建中汤加减结合优甲乐对桥本甲状腺炎患者细胞因子和抗体水平的影响[J].现代中西医结合杂志,2016,25(27):3001-3003.
[13] Judith M,Jose V,Jerome VW,et al.Estrogen,Estrogen-like molecules and autoimmune diseases[J].Autoimmun Rev,2020,19(3):102468.
[14] 常伟勤,李 凤,吴书莹.围绝经期女性雌激素水平与桥本氏甲状腺炎的相关性研究[J].中国实验诊断学,2016,20(9):1501-1503.
[15] 穆道周,胡桂芳,陈 雷,等.雌激素受体与抑郁症的相关性研究进展[J].天津医药,2019,47(4):436-439.
[16] 许琳婉,张潞渝,苟 茜,等.UHRF1调控雌激素受体表达对甲状腺乳头状癌细胞增殖、侵袭和迁移的影响[J].四川大学学报:医学版,2020,51(3):325-330.
[17] 卢亚敏,刘光霞,陈 芳,等.女性自身免疫性甲状腺疾病患者血清催乳素、雌激素水平变化及临床意义[J].中国基层医药,2019,26(23):2826-2829.
[18] 黄 慧,马瑞婷,闫 哲.雌激素在桥本氏甲状腺炎中的作用[J].西部医学,2015,27(10):1441-1444.
[19] 吕 剑.彩色多普勒超声在甲状腺功能正常桥本甲状腺炎诊断中的应用价值[J].中国中西医结合影像学杂志,2019,17(5):492-495.

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备注/Memo

备注/Memo:
*陕西省科学技术研究发展计划项目(2020PT-007)
更新日期/Last Update: 2020-11-05