[1]张彦平,贺军涛△,殷 鉴,等.尿液免疫球蛋白轻链检测对系统性红斑狼疮肾脏损伤的诊断价值*[J].陕西医学杂志,2020,49(9):1172-1174.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.030]
　ZHANG Yanping,HE Juntao,YIN Jian,et al.Diagnostic value of urine U-kap and U-lam detection in renalinjury of systemic lupus erythematosus[J].,2020,49(9):1172-1174.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.030]
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尿液免疫球蛋白轻链检测对系统性红斑狼疮肾脏损伤的诊断价值*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年9期
页码:
1172-1174
栏目:
临床检验
出版日期:
2020-09-01

文章信息/Info

Title:
Diagnostic value of urine U-kap and U-lam detection in renalinjury of systemic lupus erythematosus
作者:
张彦平; 贺军涛△; 殷 鉴; 田 莹; 姬 婧
西安交通大学第二附属医院(西安 710004)
Author(s):
ZHANG Yanping; HE Juntao; YIN Jian; et al.
The Second Affiliated Hospital of Xi'an Jiaotong University(Xi'an 710004)
关键词:
系统性红斑狼疮;  尿轻链kap;  尿轻链lam;  肾损伤;  免疫球蛋白;  狼疮性肾炎
Keywords:
Systemic lupus erythematosus;  Urinary light chain kap;  Urinary light chain lam;  Renal injury;  Immunoglobulin;  Lupus nephritis
分类号:
R593.24
DOI:
DOI:10.3969/j.issn.1000-7377.2020.09.030
文献标志码:
A
摘要:
目的:探讨人体尿液中免疫球蛋白轻链kappa型(U-kap)和lambda型(U-lam)在系统性红斑狼疮(SLE)患者肾损伤中的诊断价值。方法:采用回顾性研究方法,收集系统性红斑狼疮50例作为SLE组。另收集健康体检者20例作为对照组。比较两组尿液中U-kap、U-lam水平,分析U-kap、U-lam在SLE患者肾脏损伤中的诊断价值。结果:SLE组和对照组U-kap、U-lam水平比较,差异均有统计学意义(P<0.05)。ROC曲线分析显示,U-kap=6.94 mg/L对肾损伤诊断预测的敏感度为94%,特异度为100%,曲线下面积(AUC)为0.951; U-lam=3.81 mg/L对肾损伤诊断预测的敏感度为94%,特异度100%,AUC为0.967。结论:尿液中U-kap、U-lam在SLE患者肾脏损伤中具有良好的临床诊断价值。
Abstract:
Objective:To investigate the diagnostic value of immunoglobulin light chain kappa(U-kap)and lambda(U-lam)in the urine of patients with systemic lupus erythematosus(SLE).Methods:A retrospective study was conducted to collect 50 SLE patients as SLE group.Another 20 healthy people were collected as control group.The levels of U-kap and U-lam in urine samples of the two groups were compared,and the diagnostic value of U-kap and U-lam in renal injury of SLE patients was analyzed.Results:There was significant difference between SLE group and control group in the levels of U-kap and U-lam(P<0.05).ROC curve analysis showed that the sensitivity,specificity and AUC of U-kap= 6.94 mg/L were 94%,100% and 0.951 respectively,and the sensitivity,specificity and AUC of U-lam= 3.81 mg/L were 94%,100% and 0.967 respectively.Conclusion:U-kap and U-lam in urine have a good clinical diagnostic value in SLE patients with renal injury.

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备注/Memo

备注/Memo:
*陕西省社会发展领域项目(2017SF-156)
更新日期/Last Update: 2020-09-02