[1]李春艳,李忠原△.基于超声组学的甲状腺结节良恶性预测关键技术研究[J].陕西医学杂志,2020,49(9):1134-1137.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.020]
　LI Chunyan,LI Zhongyuan..Study on the key technique of benign and malignant thyroid nodule prediction based on ultrasomics[J].,2020,49(9):1134-1137.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.020]
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基于超声组学的甲状腺结节良恶性预测关键技术研究
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年9期
页码:
1134-1137
栏目:
临床研究
出版日期:
2020-09-01

文章信息/Info

Title:
Study on the key technique of benign and malignant thyroid nodule prediction based on ultrasomics
作者:
李春艳1; 李忠原2△
1.锦州医科大学齐齐哈尔医学院附属第一医院研究生培养基地(齐齐哈尔161041); 2.齐齐哈尔医学院附属第一医院(齐齐哈尔161041)
Author(s):
LI Chunyan; LI Zhongyuan.
The Postgraduate Bases of the First Affiliated Hospitalof Qiqihar Medical University of Jinzhou Medical University(Qiqihar 161041)
关键词:
超声组学;  甲状腺结节;  多模态诊断模型;  超声造影;  超声弹性成像;  Logistic回归分析
Keywords:
Ultrasomics;  Thyroid nodule;  Multimodal diagnostic model;  Contrast-enhanced ultrasound;  Ultrasonic elastography;  Logistic regression analysis
分类号:
R581
DOI:
DOI:10.3969/j.issn.1000-7377.2020.09.020
文献标志码:
A
摘要:
目的:研究基于超声组学的甲状腺结节良恶性预测关键技术的应用价值。方法:收集甲状腺结节患者307例(共367个甲状腺结节),其中恶性结节170个,良性结节197个。分别进行术前常规超声、超声造影以及弹性成像检查,通过多因素Logistic回归分析明确甲状腺恶性结节的独立危险因素,建立甲状腺结节多模态诊断模型。比较多模态诊断模型和常规超声、超声造影、弹性成像的诊断价值。结果:年龄≥45岁、纵横比≥1、边界不清晰、形态不规则、回声不均匀、钙化、不均匀增强、血管走形不规则以及弹性成像结节弹性评分3～4分的恶性甲状腺结节患者占比均高于良性甲状腺结节患者(P<0.05)。Logistic回归分析显示,年龄≥45岁、形态不规则、回声不均匀、不均匀增强、血管走形不规则以及弹性成像结节弹性评分3～4分均是恶性甲状腺结节的独立危险因素。多模态诊断模型鉴别诊断甲状腺良恶性结节的敏感度、特异度、准确度分别为93.5%、81.2%、86.9%,均高于常规超声、超声造影、超声弹性成像检查(P<0.05)。结论:超声多模态诊断模型对良恶性甲状腺结节的预测价值较高,可作为临床诊断良恶性甲状腺结节的有效技术手段。
Abstract:
Objective:To study the application value of the key technology of benign and malignant thyroid nodules prediction based on ultrasomics.Methods:A total of 367 thyroid nodules of 307 patients were included in the study,including 170 malignant nodules and 197 benign nodules.Preoperative routine ultrasonography,contrast-enhanced ultrasonography and elastography were performed,and the independent risk factors of malignant thyroid nodules were identified by multivariate Logistic regression analysis,and the multimodal diagnosis model of thyroid nodules was established.The diagnostic value of the multimodal diagnostic model and routine ultrasonography,contrast-enhanced ultrasonography and elastography was compared.Results:The proportion of malignant thyroid nodules patients with age ≥45 years old,aspect ratio ≥1,unclear borders,irregular morphology,uneven echo,calcification,uneven enhancement,irregular vessel shape and nodule elasticity score of 3 to 4 was higher than that of benign thyroid nodules(P<0.05).Logistic regression analysis showed that age ≥45 years old,irregular morphology,uneven echo,uneven enhancement,irregular vessel shape and nodule elasticity score of 3 to 4 were independent risk factors for malignant thyroid nodules.The sensitivity,specificity and accuracy of the multimodal diagnostic model for differential diagnosis of benign and malignant thyroid nodules were 93.5%,81.2% and 86.9%,respectively,which were higher than those ofoutine ultrasonography,contrast-enhanced ultrasonography and elastography(P<0.05).Conclusion:Multimodal diagnosis model has high predictive value for benign and malignant thyroid nodules,and can be used as an effective technical means for clinical diagnosis of benign and malignant thyroid nodules.

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更新日期/Last Update: 2020-09-02