[1]刘国文,李 炎.循环式单面光疗与间断式单面光疗治疗葡萄糖-6-磷酸脱氢酶缺乏所致新生儿高胆红素血症临床疗效对比分析*[J].陕西医学杂志,2020,49(9):1110-1113.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.014]
　LIU Guowen,LI Yan..Comparative analysis of the clinical efficacy of cyclic single-sided phototherapy and intermittent single-sided phototherapy in treatment of neonatal hyperbilirubinemia caused by G6PD deficiency[J].,2020,49(9):1110-1113.[doi:DOI:10.3969/j.issn.1000-7377.2020.09.014]
点击复制

循环式单面光疗与间断式单面光疗治疗葡萄糖-6-磷酸脱氢酶缺乏所致新生儿高胆红素血症临床疗效对比分析*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年9期
页码:
1110-1113
栏目:
临床研究
出版日期:
2020-09-01

文章信息/Info

Title:
Comparative analysis of the clinical efficacy of cyclic single-sided phototherapy and intermittent single-sided phototherapy in treatment of neonatal hyperbilirubinemia caused by G6PD deficiency
作者:
刘国文1; 李 炎2
1.广东省梅州市兴宁鸿惠医院新生儿科(梅州 514500); 2.广东省梅州市人民医院新生儿科(梅州 514031)
Author(s):
LIU Guowen;  LI Yan.
Department of Neonatology, Honghui Hospital, Xingning, Meizhou City, Guangdong Province(Meizhou 514500)
关键词:
循环式单面光疗;  间断式单面光疗;  G6PD缺乏症;  高胆红素血症;  疗效
Keywords:
Circulating single-sided phototherapy;  Intermittent single-sided phototherapy;  G6PD deficiency;  Hyperbilirubinemia;  Efficacy
分类号:
R722.17
DOI:
DOI:10.3969/j.issn.1000-7377.2020.09.014
文献标志码:
A
摘要:
目的:探讨循环式单面光疗与间断式单面光疗治疗遗传性葡萄糖-6-磷酸脱氢酶(G6PD)缺乏所致新生儿高胆红素血症的临床疗效。方法:选取G6PD缺乏症所致高胆红素血症的新生儿150例,按照随机双盲法分为循环组和间断组。循环组给予循环式单面蓝光治疗,间断组给予间断式单面蓝光治疗。对比两组患儿临床疗效。结果:间断组患儿治疗有效率为96.00%,循环组患儿治疗有效率为93.33%,两组比较差异无统计学意义(P>0.05)。两组患儿经治疗后血清胆红素(STB)水平不断降低,组内0 h、24 h、72 h对比,差异均具有统计学意义(均P<0.05); 组间24 h、72 h对比,循环组STB水平均低于间断组(P<0.05)。治疗48 h后,循环组患儿Hb水平和红细胞计数均低于对照组(P<0.05)。循环组患儿不良反应发生率为6.67%,低于间断组的28.00%,差异具有统计学意义(P<0.05)。循环组患儿黄疸消退时间和住院时间均短于间断组(P<0.05)。结论:循环式单面光疗与间断式单面光疗对G6PD缺乏症所致高胆红素血症均具有较好的临床疗效,但前者有更多优势。
Abstract:
Objective:To investigate the clinical efficacy of cyclic single-sided phototherapy and intermittent single-sided phototherapy in treatment of neonatal hyperbilirubinemia caused by genetic G6PD deficiency.Methods:150 neonates with hyperbilirubinemia caused by G6PD deficiency were randomly divided into cyclic group and discontinuous group.The former was treated with cyclic single-sided phototherapy, and the latter was treated with intermittent single-sided phototherapy.The clinical efficacy were compared.Results:The effective rate was 96.00% in discontinuous group and 93.33% in cyclic group(P>0.05).The STB levels in two groups were continuously decreased after treatment, and the differences were statistically significant in 0, 24 and 72 hours(all P<0.05).The STB levels in cyclic group in 24 and 72 hours were lower than those in discontinuous group(P<0.05).After 48 hours of treatment, Hb level and red blood cell count in cyclic group were lower than those in discontinuous group(P<0.05).The incidence of adverse reactions in cyclic group was lower than that in discontinuous group(6.67% vs.28.00%)(P<0.05).The jaundice regression time and hospitalization time in cyclic group were shorter than those in discontinuous group(P<0.05).Conclusion:Cyclic single-sided phototherapy and intermittent single-sided phototherapy have good clinical effects on hyperbilirubinemia caused by G6PD deficiency, and can reduce the level of STB in children.However, the former has more advantages.

参考文献/References:

[1] 卢伟能,周艳霞,荣 箫,等.经外周动静脉全自动换血术治疗高胆红素血症新生儿前后脑电活动的变化[J].中华实用儿科临床杂志,2016,31(12):919-922.
[2] 孙素珂,文建国,李真珍,等.蓝光治疗对高胆红素血症新生儿排尿方式的影响[J].中华实用儿科临床杂志,2014,29(14):1070-1073.
[3] 代勤韵.强光疗与传统光疗治疗新生儿高胆红素血症的疗效观察[J].重庆医学,2017,46(13):1827-1829.
[4] Honar N,Ghashghaei SE,Saki F,et al.Effect of ursodeoxycholic acid on indirect hyperbilirubinemia in neonates treated with phototherapy[J].Journal of Pediatric Gastroenterology and Nutrition,2016,62(1):97-100.
[5] 韩伟娟.中西医结合治疗新生儿高胆红素血症[J].中国医刊,2016,51(6):7-8.
[6] 陈继昌,蒋永江,韦 拔,等.强化光疗治疗新生儿高胆红素血症的临床研究[J].中国妇幼保健,2016,31(8):1667-1669.
[7] 庄 严,李贵南,周 勇,等.新生儿重度高胆红素血症伴听力损伤预后相关因素研究[J].中国新生儿科杂志,2014,29(6):376-380.
[8] Uhrikova Z,Zibolen M,Javorka K,et al.Hyperbilirubinemia and phototherapy in newborns:effects on cardiac autonomic control[J].Early Hum Dev,2015,91(6):351-356.
[9] 朴梅花.新生儿重症高胆红素血症的防治重在生后早期的规范管理[J].中华围产医学杂志,2016,19(11):801-804.
[10] Rashedy FH,El-Hawy MA,Helwa MA,et al.Effect of phototherapy on CD4,CD8 and natural killer cells of full term neonates with indirect hyperbilirubinemia[J].Egypt Immunol,2015,22(2):23-29.
[11] 梁 虹.早期检测血清胱抑素C在新生儿ABO溶血病高胆红素血症肾功能损害中的诊断价值[J].中国妇幼保健,2017,32(10):2144-2145.
[12] Yahia S,Shabaan AE,Gouida M,et al.Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants[J].Eur Pediatr,2015,174(4):459-464.
[13] 华旭丹.不同方法蓝光照射治疗新生儿高胆红素血症的疗效[J].中国妇幼保健,2012,27(17):2715-2716.
[14] Can E,Verim A,Baser E,et al.Auditory neuropathy in late preterm infants treated with phototherapy for hyperbilirubinemia[J].Int Audiol,2015,54(2):89-95.
[15] 李 峥,谭华清,庞兴甫,等.新生儿高胆红素血症的临床处理及危险因素分析[J].中国临床医生杂志,2016,44(1):87-89.
[16] Isa HM,Mohamed MS,Mohamed AM,et al.Neonatal indirect hyperbilirubinemia and glucose-6-phosphate dehydrogenase deficiency[J].Korean Journal of Pediatrics,2017,60(4):106-111.

备注/Memo

备注/Memo:
*广东省梅州市社会发展科技计划项目(2017B159)
更新日期/Last Update: 2020-09-02