[1]陈宥艺,段海霞,安 静,等.控制性超促排卵黄体期患者血清孕酮、雌二醇及白细胞介素-1β水平对胚胎着床的影响*[J].陕西医学杂志,2020,49(8):979.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.017]
　CHEN Youyi,DUAN Haixia,AN Jing,et al.Effects of serum P,E2 and IL-1β Levels on embryo implantation after superovulation during progesational stage[J].,2020,49(8):979.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.017]
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控制性超促排卵黄体期患者血清孕酮、雌二醇及白细胞介素-1β水平对胚胎着床的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
979
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Effects of serum P,E2 and IL-1β Levels on embryo implantation after superovulation during progesational stage
作者:
陈宥艺1; 段海霞2; 安 静1; 赵 静1△
1.西安市第四医院生殖医学中心(西安710004); 2.西北妇女儿童医院生殖妇科(西安710003)
Author(s):
CHEN Youyi; DUAN Haixia; AN Jing; et al.
Department of Reproductive Medicine,Xi'an No.4 Hospital(Xi'an 710004)
关键词:
体外受精-胚胎移植;  超排卵;  孕酮;  雌二醇;  白细胞介素-1β;  胚胎着床
Keywords:
In vitro fertilization-embryo transfer;  Superovulation;  Progesterone;  Estradiol;  Interleukin-1β;  Embryo implantation
分类号:
R711.6
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.017
文献标志码:
A
摘要:
目的:探讨控制性超促排卵黄体期患者血清孕酮(P)、雌二醇(E2)及白细胞介素-1β(IL-1β)水平对胚胎着床的影响。方法:选择80例体外受精-胚胎移植(IVF-ET)患者,所有患者均采用黄体期长方案促排卵治疗,于新鲜周期移植后第7天采集静脉血检测血清P、E2及IL-1β水平,观察胚胎着床妊娠情况,对比妊娠组(n=31)与非妊娠组(n=49)血清指标的差异,通过Logistic回归分析血清P、E2及IL-1β水平对胚胎着床的影响。结果:妊娠组获卵数、受精率、优质胚胎率均高于非妊娠组(P<0.05); 妊娠组血清P、IL-1β水平以及P/E2比值高于非妊娠组(P<0.05); 妊娠组E2水平低于非妊娠组(P<0.05); 黄体期血清P/E2值为300～400时的妊娠率62.50%,P/E2值<300时的妊娠率27.27%,P/E2值≥400时的妊娠率33.33%(P<0.05); 黄体期血清IL-1β≥80 pg/ml时妊娠率达到64.52%,高于IL-1β<80 pg/ml的妊娠率22.45%(P<0.05); Logisitic回归分析显示年龄、移植胚胎级别、血清P/E2、IL-1β是着床成功的影响因素。结论:黄体期长方案超促排卵后黄体期血清P/E2比值为300～400,IL-1β水平高于80 pg/ml时着床成功的可能性更高。
Abstract:
Objective:To explore the effects of serum progesterone(P),estradiol(E2)and interleukin-1β(IL-1β)levels on embryo implantation after superovulation during progesational stage.Methods:Eighty patients who underwent in vitro fertilization-embryo transfer(IVF-ET)were enrolled.All were treated with ovulation induction.On the 7th day after egg retrieval,venous blood was collected to detect levels of serum P,E2 and IL-1β.The embryo implantation and pregnancy were observed.The differences in serum indexes were compared between pregnancy group(n=31)and non-pregnancy group(n=49).The effects of serum P,E2 and IL-1β levels on embryo implantation were analyzed by Logistic regression analysis.Results:The number of retrieved oocytes,fertilization rate and high-quality embryos rate in pregnancy group were higher than those in non-pregnancy group(P<0.05).The levels of serum P and IL-1β,and P/E2 in pregnancy group were higher than those in non-pregnancy group(P<0.05),while E2 level was lower than that in non-pregnancy group(P<0.05).During progesational stage,the pregnancy rate was 62.50% when P/E2 was 300-400,27.27% when P/E2 was less than 300,33.33% when P/E2 was more than 400(P<0.05); the pregnancy rate in patients with serum IL-1β not lower than 80pg/ml was higher than that with serum IL-1β lower than 80 pg/ml(64.52% vs. 22.45%)(P<0.05).Logisitic regression analysis showed that age,grade of transferred embryos,serum P/E2 and IL-1β were influencing factors of successful implantation.Conclusion:When serum P/E2 is 300-400 and IL-1β level is higher than 80 pg/ml after superovulation during progesational stage,the possibility of successful implantation is higher.

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备注/Memo

备注/Memo:
*陕西省社会发展领域一般项目(2019SF-118)
更新日期/Last Update: 2020-08-04