[1]毛小梅,拓海荣△.孕期血脂异常对高龄妊娠期糖尿病孕妇围产结局的影响*[J].陕西医学杂志,2020,49(8):972-974.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.015]
　MAO Xiaomei,TUO Hairong..Effects of changes of blood lipids during pregnancy on perinatal outcome of elderly pregnant women with gestational diabetes[J].,2020,49(8):972-974.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.015]
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孕期血脂异常对高龄妊娠期糖尿病孕妇围产结局的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
972-974
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Effects of changes of blood lipids during pregnancy on perinatal outcome of elderly pregnant women with gestational diabetes
作者:
毛小梅1; 拓海荣2△
1.西安医学院附属宝鸡医院妇产科(宝鸡721006); 2.陕西省延安市宝塔区妇幼保健计划生育服务中心妇产科(延安 716000)
Author(s):
MAO Xiaomei; TUO Hairong.
Department of Obstetrics and Gynecology,Affiliated Baoji Hospital of Xi'an Medical University(Baoji 721006)
关键词:
妊娠期糖尿病;  孕妇;  高脂血症;  巨大儿;  新生儿低血糖;  剖宫产;  妊娠高血压
Keywords:
Gestational diabetes mellitus;  Pregnant women;  Hyperlipidemia;  Macrosomia;  Neonatal hypoglycemia;  Cesarean section;  Gestational hypertension
分类号:
R714.252
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.015
文献标志码:
A
摘要:
目的:探讨孕期血脂异常对高龄妊娠期糖尿病孕妇围产结局的影响。方法:选择高龄妊娠期糖尿病患者280例,检测其血脂水平,调查围产结局并进行相关性分析。结果:在280例孕妇中,诊断为高脂血症80例为高脂血症组,发生率为28.6%; 血脂正常孕妇200例为对照组。两组孕妇都顺利分娩,无孕产妇与新生儿死亡,高脂血症组的巨大儿发生率为21.3%,显著高于对照组的4.0%(P<0.05)。高脂血症组新生儿低血糖、剖宫产、妊娠期高血压和早产的发生率亦显著高于对照组(P<0.05)。Pearson相关系数分析显示高龄妊娠期糖尿病孕妇的空腹血糖、餐后2 h血糖、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)都与不良围产结局显著相关(P<0.05)。多因素Logistic回归分析显示空腹血糖、餐后2 h血糖、LDL-C、TG、HDL-C为影响不良围产结局发生的主要因素(P<0.05)。结论:高龄妊娠期糖尿病孕妇多伴随有高脂血症,其可增加不良围产结局的发生几率,两者具有相关性。
Abstract:
Objective:To explore and analyze the effect of changes of blood lipids during pregnancy on perinatal outcome of elderly pregnant women with gestational diabetes.Methods:280 cases of elderly pregnant women with gestational diabetes mellitus were selected,their blood lipid level was measured,perinatal outcome was investigated and correlation analysis was carried out.Results:Among 280 pregnant women,80 cases were diagnosed as hyperlipidemia,the incidence was 28.6%.Both groups of pregnant women delivered successfully,No maternal and neonatal death.The incidence of macrosomia in hyperlipidemia group was 21.3%,which was significantly higher than that in control group(4.0%)(P<0.05).The incidence of neonatal hypoglycemia,cesarean section,gestational hypertension and preterm delivery in hyperlipidemia group were also significantly higher than that in the control group(P<0.05).Pearson correlation analysis showed that fasting blood glucose,2 hours postprandial blood glucose,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in elderly diabetic pregnant women were significantly correlated with adverse perinatal outcome(P<0.05).Multivariate Logistic regression analysis showed that fasting blood glucose,2 hours postprandial blood glucose,LDL-C,TG and HDL-C were the main factors influencing the adverse perinatal outcome(P<0.05).Conclusion:Most elderly pregnant women with gestational diabetes mellitus are accompanied by hyperlipidemia,which can also increase the incidence of adverse perinatal outcome.The two have a good correlation.

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备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2016RJM187)
更新日期/Last Update: 2020-08-04