[1]周 璇,刘海静,白 洁△.经腹超声造影鉴别诊断子宫内膜病变价值及与微血管密度关系探讨*[J].陕西医学杂志,2020,49(8):960-963.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.012]
　ZHOU Xuan,LIU Haijing,BAI Jie..Value of transabdominal contrast-enhanced ultrasonography in the differential diagnosis of endometrial lesions and its relationship with microvessel density[J].,2020,49(8):960-963.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.012]
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经腹超声造影鉴别诊断子宫内膜病变价值及与微血管密度关系探讨*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
960-963
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Value of transabdominal contrast-enhanced ultrasonography in the differential diagnosis of endometrial lesions and its relationship with microvessel density
作者:
周 璇1; 刘海静2; 白 洁2△
1.陕西省第二人民医院超声医学诊断科(西安710004); 2.空军军医大学西京医院超声医学诊断科(西安710032)
Author(s):
ZHOU Xuan; LIU Haijing; BAI Jie.
Department of Ultrasound Diagnosis, the Second People's Hospital of Shaanxi Province(Xi'an 710004)
关键词:
子宫内膜病变;  诊断;  超声造影;  内膜厚度;  微血管密度;  峰值强度
Keywords:
Endometrial lesion;  Diagnosis;  Contrast-enhanced ultrasonography;  Endometrial thickness;  Microvessel density;  Peak intensity
分类号:
R711.7
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.012
文献标志码:
A
摘要:
目的:探讨经腹超声造影鉴别诊断子宫内膜病变价值及与微血管密度的关系。方法:回顾性分析86例子宫内膜病变患者的临床资料,所有患者均接受经腹超声造影检查,根据病理学结果分为恶性组(n=32)和良性组(n=54)。比较两组经腹超声造影相关参数,以病理学结果为金标准,绘制受试者工作曲线(ROC)分析经腹超声造影相关参数鉴别良恶性子宫内膜病变的诊断效能。病理标本行免疫组织化学染色检测微血管密度(MVD),分析经腹超声造影相关参数与MVD的相关性。结果:恶性组峰值强度高于良性组,达峰时间、上升时间均短于良性组(P<0.05); 由ROC曲线可知,经腹超声造影相关参数以峰值强度鉴别良恶性子宫内膜病变的价值最大,其AUC为0.841,达峰时间、上升时间鉴别良恶性子宫内膜病变的价值相对较低,其AUC分别为0.837、0.802; 恶性组MVD显著高于良性组(P<0.05); Pearson线性相关分析结果显示,峰值强度与MVD呈正相关(r=0.455,P=0.000),达峰时间与MVD呈负相关(r=-0.415,P=0.000),上升时间与MVD呈负相关(r=-0.340,P=0.001)。结论:经腹超声造影在鉴别诊断子宫内膜病变中具有较高的价值,峰值强度、达峰时间、上升时间与微血管密度有相关性,可以为临床评价微血管密度提供依据。
Abstract:
Objective:To explore the value of transabdominal contrast-enhanced ultrasonography(CEUS)in the differential diagnosis of endometrial lesions and its relationship with microvessel density(MVD).Methods:The clinical data of 86 patients with endometrial lesions were retrospectively analyzed.All underwent transabdominal CEUS.According to pathological results,they were divided into malignant group(n=32)and benign group(n=54).The related parameters of transabdominal CEUS were compared between the two groups.Taking pathological results as the gold standard,receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficiency of transabdominal CEUS related parameters in identifying benign and malignant endometrial lesions.Pathological specimens were tested by immunohistochemical staining to detect MVD.The correlation between transabdominal CEUS related parameters and MVD was analyzed.Results:The peak intensity of malignant group was higher than that of benign group,while time to peak and rise time were shorter than those of benign group(P<0.05).ROC curve showed that in the related parameters of transabdominal CEUS,the value of peak intensity(AUC=0.841)was the greatest for identifying benign and malignant endometrial lesions.The value of time to peak and rise time was relatively lower(AUC=0.837,0.802).MVD in malignant group was significantly higher than that in benign group(P<0.05).The results of Pearson linear correlation analysis showed that the peak intensity was positively correlated with MVD(r=0.455,P=0.000),time to peak was negatively correlated with MVD(r=-0.415,P=0.000),and rise time was negatively correlated with MVD(r=-0.340,P=0.001).Conclusion:Transabdominal CEUS is of relatively higher value in the differential diagnosis of endometrial lesions.The peak intensity,time to peak and rise time are related to MVD,which can provide basis for clinical evaluation of MVD.

参考文献/References:

[1] 孙艳红.经阴道超声技术诊断子宫内膜病变的应用价值及影像学特征分析[J].医学理论与实践,2020,33(1):127-128.
[2] 杨秀梅,毕 翠,邵迎华,等.经阴道多普勒超声与宫腔镜检查在子宫内膜病变中的诊断价值[J].医学临床研究,2020,37(1):26-28.
[3] 赵海英,马雪梅,庞海燕,等.彩色多普勒超声在子宫内膜癌早期诊断中血流动力学参数测定的价值[J].中国老年学杂志,2019,39(23):5695-5697.
[4] 徐 嘉,谯 朗,汪 洋,等.超声造影对子宫内膜病变的诊断价值[J].中华妇幼临床医学杂志:电子版,2018,14(5):535-541.
[5] 邓弼云,陆敏姣,姬亚敏,等.超声静脉造影和腔内造影在鉴别诊断绝经后子宫内膜良恶性病变中的应用价值[J].中国医师杂志,2019,21(4):561-564.
[6] 马红霞,毛美君,安利红,等.子宫内膜癌患者彩色多普勒超声血流参数、MVD、VEGF水平及其与临床病理特征的关系[J].中国妇幼保健,2018,33(8):1888-1890.
[7] 钟树兴,郭红梅,吴斯瑶,等.经阴道超声联合三维容积成像技术对子宫内膜病变的诊断价值[J].海南医学,2019,30(14):1837-1840.
[8] 杨秀梅,刘 洋,邵迎华,等.宫腔镜及超声检查在子宫内膜病变诊断中的价值[J].中国医学装备,2019,16(4):88-91.
[9] 强 也,朱正球,司海鹏,等.超声造影定量指标在鉴别子宫内膜增生不同病理分型中的应用价值[J].中国计划生育和妇产科,2018,10(4):53-57.
[10] 刘支义,安 邦,胡亚飞,等.子宫内膜良恶性病变的超声造影参数测定及其与恶性分子表达的相关性研究[J].海南医学院学报,2017,23(22):3116-3119,3123.
[11] Su Q,Sun Z,Lv G.Contrast enhanced ultrasound in diagnosis of endometrial carcinoma and endometrial hyperplasia[J].Cell Mol Biol(Noisylegrand),2018,64(11):88-91.
[12] 余炜萍.超声造影定量在子宫内膜病变定性诊断及预后中的应用价值[J].临床医学研究与实践,2018,3(32):163-164.
[13] 徐阿巧,赵振华,杨建峰,等.子宫平滑肌瘤MRI定量灌注参数与肿瘤微血管密度、VEGF及Ki-67的相关性研究[J].中华全科医学,2018,16(4):606-610.
[14] 田 昆,谷利宏.阴道超声血流灌注定量参数与宫颈癌临床分期和病灶内血管情况的关系[J].中国肿瘤临床与康复,2019,26(2):170-173.
[15] 谢国平,何志忠,李 霞.肝细胞癌实时超声造影灌注参数与肿瘤微血管的相关性[J].安徽医药,2020,24(2):366-369.

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备注/Memo

备注/Memo:
*陕西省卫生科研基金资助项目(2015-CS)
更新日期/Last Update: 2020-08-04