[1]赵卓伟,华 振,霍君艺,等.弹力压迫硅胶喷剂外用联合强脉冲光治疗烧伤后瘢痕增生疗效及安全性研究*[J].陕西医学杂志,2020,49(8):951-954.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.010]
　ZHAO Zhuowei,HUA Zhen,HUO Junyi,et al.Clinical effect and safety of elastic compression silicone spray for external application combined with intense pulsed light in treatment of scar hyperplasia after burn[J].,2020,49(8):951-954.[doi:DOI:10.3969/j.issn.1000-7377.2020.08.010]
点击复制

弹力压迫硅胶喷剂外用联合强脉冲光治疗烧伤后瘢痕增生疗效及安全性研究*
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年8期
页码:
951-954
栏目:
临床研究
出版日期:
2020-08-05

文章信息/Info

Title:
Clinical effect and safety of elastic compression silicone spray for external application combined with intense pulsed light in treatment of scar hyperplasia after burn
作者:
赵卓伟; 华 振; 霍君艺; 荆银磊; 孟祥海△
空军军医大学唐都医院整形烧伤科(西安710038)
Author(s):
ZHAO Zhuowei; HUA Zhen; HUO Junyi; et al.
Department of Burn and Plastic Surgery,Tangdu Hospital of Air Force Military Medical University(Xi'an 710038)
关键词:
烧伤;  瘢痕增生;  治疗;  弹力压迫硅胶喷剂;  强脉冲光;  安全性
Keywords:
Burn;  Scar hyperplasia;  Therapy;  Elastic compression silicone spray;  Intense pulsed light;  Safety
分类号:
R644
DOI:
DOI:10.3969/j.issn.1000-7377.2020.08.010
文献标志码:
A
摘要:
目的:探讨弹力压迫硅胶喷剂外用联合强脉冲光治疗烧伤后瘢痕增生的临床效果及安全性。方法:烧伤后瘢痕增生患者84例(651处烧伤),采用随机数表法分为观察组和对照组各42例。对照组给予弹力压迫硅胶喷剂外用治疗,观察组在对照组基础上加施强脉冲光治疗,均持续治疗4个月。于治疗结束后评估两组临床疗效,比较两组治疗前后瘢痕厚度、胶原纤维面密度、温哥华瘢痕量表(VSS)和中文版精简烧伤健康量表(BSHS-B)评分,记录两组治疗期间不良反应发生情况。结果:治疗后观察组的总有效率为90.06%,明显高于对照组的84.95%,两组间比较差异有统计学意义(P<0.05); 治疗后两组患者的瘢痕厚度、胶原纤维面密度、VSS评分均较治疗前减小,BSHS-B评分较治疗前上升,两组间比较差异有统计学意义(P<0.05); 观察组治疗后的瘢痕厚度、胶原纤维面密度、VSS评分明显小于对照组治疗后,BSHS-B评分明显大于对照组治疗后,两组间比较差异有统计学意义(P<0.05); 两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:弹力压迫硅胶喷剂外用联合强脉冲光治疗烧伤后瘢痕增生临床效果确切且安全性较高。
Abstract:
Objective:To analyze the clinical effect and safety of elastic compression silicone spray for external application combined with intense pulsed light(IPL)in the treatment of scar hyperplasia after burn.Methods:84 patients(burns at 651 sites)with scar hyperplasia after burn were divided into observation group and control group according to random number table method,42 cases in each group.The control group was treated with elastic compression silicone spray for external application,while the observation group was additionally treated with IPL.All were continuously treated for 4 months.After treatment,the clinical curative effect of both groups was evaluated.The scar thickness,density of collagen fiber surface,scores of Vancouver scar scale(VSS)and burn specific health scale-brief(BSHS-B)before and after treatment were compared between the two groups.The occurrence of adverse reactions during treatment in both groups was recorded.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group(90.06% vs.84.95%)(P<0.05); the scar thickness,density of collagen fiber surface and VSS scores of both groups were significantly decreased,while BSHS-B scores were significantly increased(P<0.05); the scar thickness,density of collagen fiber surface and VSS scores in the observation group were significantly less than those in the control group,while BSHS-B scores were significantly higher than those in the control group(P<0.05); there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical curative effect of elastic compression silicone spray for external application combined with IPL is effective and safe in the treatment of scar hyperplasia after burn.

参考文献/References:

[1] 沈余明.深度烧伤后瘢痕增生挛缩畸形的手术治疗[J].中华烧伤杂志,2019,35(6):401-404.
[2] 李 莉,赵宇辉,于晓牧,等.强脉冲光联合压力疗法治疗烧伤患者瘢痕增生的疗效观察[J].中华物理医学与康复杂志,2016,38(8):610-611.
[3] 徐庆连,宋均辉.小儿烧伤后瘢痕增生特点与康复治疗方案[J].中华烧伤杂志,2018,34(8):509-512.
[4] 行 敏,赵凤梅,吴 洁,等.CO2点阵激光联合紫草治疗增生性瘢痕临床疗效及对血清中VEGF的影响[J].中国皮肤性病学杂志,2018,32(1):110-114.
[5] 陈叶恒,范原铭,王 强.弹力压迫硅胶喷剂外喷及局部曲安奈德注射防治烧伤后瘢痕形成临床探讨[J].陕西医学杂志,2016,45(7):853-855.
[6] 周剑峰,樊 昕,刘丽红,等.点阵式强脉冲光治疗黄褐斑和炎症后色素沉着的临床观察[J].实用皮肤病学杂志,2017,10(4):231-233.
[7] 全 根,孙红河,任文明,等.微等离子射频联合窄谱强脉冲光治疗浅表性和增生性瘢痕[J].实用皮肤病学杂志,2017,10(3):147-149.
[8] 侯晓华,沙德潜,李德水,等.强脉冲光治疗烧伤后增生性瘢痕的临床疗效观察[J].医疗卫生装备,2012,33(4):78-80.
[9] Forbes-Duchart L,Marshall S,Strock A,et al.Determination of inter-rater reliability in pediatric burn scar assessment using a modified version of the vancouver scar scale[J].Journal of Burn Care & Research,2007,28(3):460-467.
[10] 陈 斌.行为医学量表手册[M].北京:中华电子音像出版社,2005:114-115.
[11] 刘洪琪,闫 利,邢玉玺,等.脱细胞异体真皮与自体皮复合移植一期修复面部Ⅲ度烧伤创面[J].中国急救复苏与灾害医学杂志,2013,8(2):139-142.
[12] 柏 杨.疤痕软膏配合醋酸曲安奈德治疗增生性瘢痕60例[J].陕西中医,2012,33(6):696-697.
[13] 翁旭豪,马小亚,杨学荣,等.弹力压迫硅胶喷剂外喷及局部曲安奈德注射防治烧伤后瘢痕形成的探讨[J].临床军医杂志,2014,42(2):168-170.
[14] 蒋 丹,张长风,郭 鱼,等.弹力压迫硅胶喷剂外用联合曲安奈德注射治疗烧伤后瘢痕增生的效果观察[J].中国美容医学,2019,28(1):45-47.
[15] 丁架月,李 华.强脉冲光联合硅凝胶贴对增生性瘢痕早期干预的效果分析[J].中国激光医学杂志,2019,28(5):261-265.
[16] Shui Y,Hengjin L.Microplasma radiofrequency technology combined with triamcinolone improved the therapeutic effect on Chinese patients with hypertrophic scar and reduced the risk of tissue atrophy[J].Therapeutics & Clinical Risk Management,2016,12(1):743-747.
[17] 李相国,杜万雪,徐娅丽,等.基于ILK信号通路探究马桑水提取物影响大鼠烧伤创面愈合和瘢痕增生的机制[J].中国病理生理杂志,2020,36(2):336-345.
[18] 姜耀男,王雨翔,郑勇军,等.含异体角质形成细胞和成纤维细胞的细胞膜片治疗Ⅱ度烧伤创面的临床研究[J].中华烧伤杂志,2020,36(3):171-178.
[19] Sarkar A,Dewangan YK,Bain J,et al.Effect of intense pulsed light on immature burn scars:a clinical study[J].Indian Journal of Plastic Surgery,2014,47(3):381-385.
[20] Jang JY,Han JH,Yoon KC,et al.Early management of scars using a 532-nm Nd:YAG laser[J].Archives of Aesthetic Plastic Surgery,2017,23(2):62-67.

相似文献/References:

[1]石雪芹,胡大海,王耘川,等.表皮细胞种植技术治疗深Ⅱ°烧伤创面临床疗效研究[J].陕西医学杂志,2021,50(5):594.[doi:DOI:10.3969/j.issn.1000-7377.2021.05.020]
　SHI Xueqin,HU Dahai,WANG Yunchuan,et al.Clinical effect of epidermal cell implantation in treatment of deep secondary-degree burn wounds[J].,2021,50(8):594.[doi:DOI:10.3969/j.issn.1000-7377.2021.05.020]
[2]华 振,赵卓伟,段策中,等.烧伤整形患者血清Toll样受体4和髓样细胞触发受体1表达水平及影响因素分析[J].陕西医学杂志,2022,51(9):1071.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.006]
　HUA Zhen,ZHAO Zhuowei,DUAN Cezhong,et al.Expression levels of serum Toll-like receptor 4 and triggering receptor expressed on myeloid cell 1 in burn and plastic surgery patients and their influencing factors[J].,2022,51(8):1071.[doi:DOI:10.3969/j.issn.1000-7377.2022.09.006]

备注/Memo

备注/Memo:
*陕西省自然科学基金资助项目(2010JM4044)
更新日期/Last Update: 2020-08-04