[1]李子杰,马妮娜,柴小奇,等.阿司匹林联合氟桂利嗪对脑梗死患者血液流变学及神经功能的影响分析*[J].陕西医学杂志,2020,49(7):878-880.[doi:DOI:10.3969/j.issn.10007377.2020.07.030]
　LI Zijie,MA Nina,CHAI Xiaoqi,et al.Effect of aspirin combined with flunarizine on hemorheology and neurological function in patients with cerebral infarction[J].,2020,49(7):878-880.[doi:DOI:10.3969/j.issn.10007377.2020.07.030]
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阿司匹林联合氟桂利嗪对脑梗死患者血液流变学及神经功能的影响分析*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
49
期数:
2020年7期
页码:
878-880
栏目:
药物与临床
出版日期:
2020-07-05

文章信息/Info

Title:
Effect of aspirin combined with flunarizine on hemorheology and neurological function in patients with cerebral infarction
作者:
李子杰; 马妮娜; 柴小奇; 罗 超
陕西省汉中市中心医院(汉中 723000)
Author(s):
LI Zijie; MA Nina; CHAI Xiaoqi; et al.
Hanzhong Central Hospital,Shaanxi Province(Hanzhong 723000)
关键词:
阿司匹林;  氟桂利嗪;  脑梗死;  血液流变学;  神经功能
Keywords:
Aspirin;  Flunarizine;  Cerebral infarction;  Hemorheology;  Neurological function
分类号:
R743
DOI:
DOI:10.3969/j.issn.10007377.2020.07.030
文献标志码:
A
摘要:
目的:探究阿司匹林联合氟桂利嗪对脑梗死患者血液流变学及神经功能的影响。方法:选取110例脑梗死患者,随机将其分为两组,其中观察组55例患者应用阿司匹林(100 mg/次,3次/d)联合氟桂利嗪(10 mg/次,3次/d)治疗,对照组55例患者应用阿司匹林单药治疗,对比其治疗前后的美国国立卫生院神经功能缺损评分(NIHSS)评分、血液流变学指标及治疗效果。结果:观察组患者在治疗后的血小板聚集率、全血低切黏度、血液黏度相比于对照组均显著下降,差异具有统计学意义(P<0.05)。治疗后两组患者NIHSS评分均明显下降,且观察组下降幅度更为显著,差异具有统计学意义(P<0.05)。对照组治疗总有效率78.18%(43/55)明显低于观察组总有效率92.72%(51/55),差异有统计学意义(χ2=3.889,P=0.047)。结论:阿司匹林联合氟桂利嗪治疗脑梗死患者能够明显改善患者血液流变学指标,促进神经功能恢复。
Abstract:
Objective:To analyze the effect of aspirin combined with flunarizine on hemorheology and neurological function in patients with cerebral infarction. Methods:110 patients with cerebral infarction were randomly divided into two groups. The observation group(55 patients)was treated with aspirin(100 mg/time,3 times a day)and flunarizine(10 mg/time,1 time a day). The control group(55 patients)was treated with aspirin alone. The NIHSS score,hemorheology indexes and treatment effect before and after the treatment were compared. Results:Compared with the control group,the platelet aggregation rate,whole blood low shear viscosity and blood viscosity in the observation group were decreased significantly(P<0.05). After treatment,the NIHSS scores of the two groups were significantly decreased,and the decrease of the observation group was more significant,the difference was statistically significant(P<0.05). The total effective rate of the control group was 78.18%(43/55),which was significantly lower than that of the observation group [92.72%(51/55)],and the difference was statistically significant(χ2=3.889,P=0.047). Conclusion:Aspirin combined with flunarizine can obviously improve the hemorheology indexes and promote the recovery of neurological function in patients with cerebral infarction.

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备注/Memo

备注/Memo:
*陕西省重点研发计划一般项目-社会发展领域(2018SF-143)
更新日期/Last Update: 2020-07-28